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1P-LSD - Probably a Pro-Drug

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JustCurious.

JustCurious.

Rising Star
Tried 1P-LSD for the first time over the weekend, absolutely mind blowing. Complete and utter insanity on 500 ug.

At breaking convention, Dave Nichols confirmed that the general consensus among he and his peers is that 1P-LSD does in fact hydrolyze in vivo to LSD. He went on to note that there is current research regarding this, so hopefully some reliable science can back this claim up in the near future.

This came as no shock to me, the experience was moar intense than any regular LSD session I've ever been involved in.

For anyone who has not tried this substance, I strongly advise that you do !
 
:) 5 hits of 1P must've been pretty strong JC, what a dose to go for your first time!

I've tried 1 hit before and it felt like LSD through and through.

Nichols told a regular on the Shroomery via email months ago that 1P must be a pro-drug because otherwise it wouldn't sit in the receptor sites/be psychoactive, it's nice to know that people are still working to confirm this.
 
Yeah Chronic it kind of crept up on me...I wasn't ready for what it showed me at the peak !

Yeah 500ug is a lot :) Not sure I could go much further than that, it was moar than enough !
 
And yeah chronic, another great thing about 1P is you are most probably receiving what it says on the tin, which is nice for once.
 
I don't think It's Just a prodrug of LSD. Perhaps it is the Purity that is the most psychoactive factor here but compared to regular stuff this thing has a more clean feel to the entire experience. I don't lose my shits as much with this one. I do say it is hardly distinguishable but I find the difference is enormous non-theless. Same thing with 4aco and psilocin. In terms of experience they are hardly even relatable to each other. But people compare them still.
 
I'll give this 1P another shot properly in a few months to compare again, i'm far too busy with LSD-25 at the moment :)

I struggle to see how anything could feel cleaner than LSD Infectedstyle, although the 1P does claim to be 99.9% so maybe it's that purity coming through... most LSD crystal i've come across claims to be >95%, the highest i've seen is crystal from Switzerland that's apparently >99.5%, maybe its a self-fulfilling prophecy but it feels extra special to me.

Would love to hear a more indepth report for your trip JustCurious, i'll try half a milligram myself someday, so far my highest dose of ~300mcg was plenty!
 
Infectedstyle said:
I do say it is hardly distinguishable but I find the difference is enormous non-theless. Same thing with 4aco and psilocin. In terms of experience they are hardly even relatable to each other. But people compare them still.
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This is the first I've heard of someone claiming there's any sort of qualitative difference between 1P-LSD and LSD itself. Can you please elaborate? Citing a comparison between 4aco and psilocin as an example is intriguing. I'm just curious what specifically you can point to that distinguishes the two substances.
 
Metanoia said:
Infectedstyle said:
I do say it is hardly distinguishable but I find the difference is enormous non-theless. Same thing with 4aco and psilocin. In terms of experience they are hardly even relatable to each other. But people compare them still.
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This is the first I've heard of someone claiming there's any sort of qualitative difference between 1P-LSD and LSD itself. Can you please elaborate? Citing a comparison between 4aco and psilocin as an example is intriguing. I'm just curious what specifically you can point to that distinguishes the two substances.
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It's certainly less notable the difference here as with psilocin. For me, it feels a little more intellectual, thoughts don't warp as much as with lsd and mental thinking is sharper somwewhat. I find 1p to be more subtle and feels less wobbly and crazy. That could be placebo. It still has most of the gimmicks so I can see why it would feel the same. I'm not sure, I probably shoulden't say that after just a few trials here and there, but 4aco is definetely different I think in a double-blind I will say they are different drugs. See for urself!

I must be wrong on so many levels since 1p-lsd supposedly theoretical inactive but other metabolites than LSD in vivo. Perhaps. :p
 
That's informative, thanks for elaborating. I'm very curious to see what experienced psychonauts have to say about the differences between 1P-LSD and LSD. I've read some reports (there aren't very many currently) and people are saying it's indistinguishable which I found hard to believe. I'll most likely find out for myself this summer :)

I do find enormous differences between psilocin and 4-aco-dmt. It doesn't sound like 1P- and LSD are so radically different...I really notice a huge difference between the acetoxy and hydroxy.
 
Nice to see people are interested in the matter anyway :)

Chronic I will probably type up some sort of rough trip report now then if it might be of use.
 
JustCurious. said:
Nice to see people are interested in the matter anyway :)

Chronic I will probably type up some sort of rough trip report now then if it might be of use.
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Please do! I am very interested in hearing how this went for you!
 
Any chance of a blinded test, to really try and compare? 100 mic of 1P and 100 mic of classic LSD?

I've always raised an eyebrow when people start talking about differences between such similar compounds. We know expectations and mindset can influence the psychedelic experience in pretty extreme ways, and since LSD has such a mythical history around it, I don't wonder if that's why people always seem to hold it up as the perfect psychedelic.

Blessings
~ND
 
Nathanial.Dread said:
Any chance of a blinded test, to really try and compare? 100 mic of 1P and 100 mic of classic LSD?

I've always raised an eyebrow when people start talking about differences between such similar compounds. We know expectations and mindset can influence the psychedelic experience in pretty extreme ways, and since LSD has such a mythical history around it, I don't wonder if that's why people always seem to hold it up as the perfect psychedelic.

Blessings
~ND
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Blind taste test of lsd and 1p lsd sounds awsome i like both 4 aco is another animal...
 
Nathanial.Dread said:
Any chance of a blinded test, to really try and compare? 100 mic of 1P and 100 mic of classic LSD?
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This is my intention. Just have to get the Ehrlich test kit.
 
I'm curious if any members may be able to locate any studies testing the hypothesis that 1P-LSD is metabolized to d-LSD in the body. While the trip is very similar on both compounds, it may be that the 1P-LSD has its own mechanism of action if it isn't changed by first pass metabolism. If it is indeed metabolised to LSD, which enzyme allows this to happen and how fast is the drug metabolized into LSD after ingestion?

This reminds me of Shulgin's commentary on 4-AcO DMT when he speculates on the subjective similiarities and differences in the experience induced by 4-AcO and 4-HO DMT. It may be that 4-AcO is metabolised to 4-HO by first pass metabolism which is why its similar to psilocin. However, if it isn't metabolised to 4-HO then that would mean that it has a different (albeit very similar) mechanism of action than psilocin. I am curious if there have been any studies published which investigate this possibility (Much of what I read appears to be pure speculation and Wikipedia, which also states this as fact, does not provide a citation to back it's statement up). Having tried both 4-AcO and mushies, I have found that there is a definite difference in the trip induced by each drug.

Having not yet sampled 1P-LSD I cannot confidently say that the experience is the same as LSD (although many trip reports suggest this is so) and would like to see if there are any publications out there which can show that it is indeed metabolized into d-LSD.

Thanks,
-Godsmacker
 
Godsmacker said:
I'm curious if any members may be able to locate any studies testing the hypothesis that 1P-LSD is metabolized to d-LSD in the body. While the trip is very similar on both compounds, it may be that the 1P-LSD has its own mechanism of action if it isn't changed by first pass metabolism. If it is indeed metabolised to LSD, which enzyme allows this to happen and how fast is the drug metabolized into LSD after ingestion?

Having not yet sampled 1P-LSD I cannot confidently say that the experience is the same as LSD (although many trip reports suggest this is so) and would like to see if there are any publications out there which can show that it is indeed metabolized into d-LSD.
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I've been scouring the net trying to find anything for the last several months, with no success. I just wanted to second this as I'm also very interested in any studies to do with 1P-LSD.
 
Godsmacker said:
Having tried both 4-AcO and mushies, I have found that there is a definite difference in the trip induced by each drug.
-Godsmacker
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If you knew what you were taking (either 4-AcO or 4-PO), I don't think it's possible to reliably conclude anything about the differences in subjective experience brought on the drug. Double blind and placebo-controlled are the gold standards in psychopharm tests for a reason, and given how much our expectations and mindsets can influence our experiences of psychedelics, it seems extremely unlikely to me that it's possible to reliably find differences between the two.

I've had mushrooms trips that were so different that you would have thought they were different drugs, but it was psilocybin both times.

Blessings
~ND
 
Had a chance for a second go with the 1P, and had one of the greatest trips of my life on 300ug. Pure magick.

I'd highly recommend it, especially if you don't have access to LSD.

(Chronic, got to try stargazing on a low dose of mushrooms the night before out in the middle of nowhere, and it was amazing. I could see across the Milky Way and even saw two shooting stars. :love: Thanks for the suggestion).
 
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