For me, DMT has affirmed that there are no answers, only more questions. I could elaborate, but it would really just be window dressing for this core theme. There's no way to delineate how DMT has altered my perceptions. I mean, how can you delineate something that is literally affecting your mind on a daily basis? It's not just that you use this substance and it alters your perceptions. The implications and meanings and lessons continue to reverberate throughout your daily life following the experience. DMT will not give your life meaning, any more than a self-help book, or guru, or any psychedelic will. You are the only person who can give your life meaning. That does not mean that it can't help you in your quest to bring meaning into your life...just don't think that a substance holds the answers which you seek. "True knowledge and understanding", to my mind, is very similar to the question of Life the Universe and Everything presented by Douglas Adams; if you were to be given the "answer" (42) you would simply realize you had no idea whatsoever as to what the question was. Welcome to the Nexus, I look forward to reading about your experience(s) and remember:
The ride does not require an explanation, just occupants, that's where you come in... :d