SWIM has been going over the literature of tryptamines and came across something rather interesting.
Apparently 5-meo-dmt can be O-demethylated by CYP2D6 (a cytochrome p450 enzyme involved in metabolism of substances that enter the body) into bufotenin. So far this has only been demonstrated in vitro but similiar drugs are metabolized in vivo along the same pathway like 5-meo-dipt.
This could explain why sublingual use of 5-meo-dmt has more visual and "lsd like" effects as opposed to smoking which is very psychedelic but for the most part non visual. When you smoke 5-meo-dmt it gets to you brain before significant metabolism can take place. But when orally or sublingually consumed it has more time to absorb and be metabolized into bufotenin which is more visual.
Taken from:
Indolealkylamines: biotransformations and potential drug drug interactions. Ai-Ming yu. AAPS journal vol 10 2008.
Apparently 5-meo-dmt can be O-demethylated by CYP2D6 (a cytochrome p450 enzyme involved in metabolism of substances that enter the body) into bufotenin. So far this has only been demonstrated in vitro but similiar drugs are metabolized in vivo along the same pathway like 5-meo-dipt.
This could explain why sublingual use of 5-meo-dmt has more visual and "lsd like" effects as opposed to smoking which is very psychedelic but for the most part non visual. When you smoke 5-meo-dmt it gets to you brain before significant metabolism can take place. But when orally or sublingually consumed it has more time to absorb and be metabolized into bufotenin which is more visual.
Taken from:
Indolealkylamines: biotransformations and potential drug drug interactions. Ai-Ming yu. AAPS journal vol 10 2008.