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amanita muscaria/pantherina tryptamines

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vlad665

Rising Star
so, i was searching for more info about my favorite mushroom i use for my chronic back pain and stumbled on this fascinating article stating that although fly agaric and panthercap are renowned for their muscimol/ibotenic acid, mostly contained in caps, these 2 marvels also contain in the stem this time, tryptamines (5-methoxy-N,N-diisopropyltryptamine (foxy methoxy) and 5-methoxy-N,N-dimethyltryptamine), aswell as the MAOIs : harmine and harmaline, with a bonus of the tropane alkaloids (atropine and scopolamine). I never kept the stems as i knew they are poor in ibo/mus but my oh my, nothing will go to waste next season.

in the article they don't specify the % of the goodies, so it would be a nice thing if a good samaritan with access to a lab could quantify the goodies in the stems.

 
Mitakuye Oyasin said:
How are you using these mushrooms for your chronic back pain?
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sundried, in the open. just leave them during the daytime in the sun, till they become cracker dry, then store them in a sealed jar with some silica gel bags. i usually eat half a small cap 3-5 cm diameter when dried, and in 1 hour maximum, all the pain is gone, and believe me, when i was in crisis, i couldn't straighten my back for a week. indomethacin was giving me a relief for a few hours or so, then the pain returned. gels like fastum gel, voltaren, horse chestnut, or hot pepper did nothing to alleviate the pain. after first experience with a. muscaria, in the for of tea, i became a true believer.
i also tried to get a breakthrough dose to go beyound and ate 8 caps of 7-10 cm diameter, but wasn't enough for me. i had a buzz like a 3-400 ml of whiskey, with no hangover. slept for 16 hours after the experience, and when i woke up i felt like a newborn.
 
vlad665 said:
so, i was searching for more info about my favorite mushroom i use for my chronic back pain and stumbled on this fascinating article stating that although fly agaric and panthercap are renowned for their muscimol/ibotenic acid, mostly contained in caps, these 2 marvels also contain in the stem this time, tryptamines (5-methoxy-N,N-diisopropyltryptamine (foxy methoxy) and 5-methoxy-N,N-dimethyltryptamine), aswell as the MAOIs : harmine and harmaline, with a bonus of the tropane alkaloids (atropine and scopolamine). I never kept the stems as i knew they are poor in ibo/mus but my oh my, nothing will go to waste next season.

in the article they don't specify the % of the goodies, so it would be a nice thing if a good samaritan with access to a lab could quantify the goodies in the stems.

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I find it very hard to believe that 5-MeO-DIPT will be occurring naturally in these, or indeed any, mushrooms.

Having a look at the abstract:

Abstract

The constituents of seven mushrooms sold as Amanita muscaria or Amanita pantherina (five A. muscaria and two A. pantherina) and four “extracts purported to contain A. muscaria” products that are currently circulated in Japan were determined. All mushroom samples were identified as A. muscaria or A. pantherina by macroscopic and microscopic observation. The dissociative constituents, ibotenic acid (IBO) and muscimol (MUS), were extracted with 70% methanol twice and determined by gas chromatography/mass spectrometry. The IBO (as the hydrate)/MUS contents were in the range of <10–2845 ppm/46–1052 ppm in the cap of A. muscaria and 188–269 ppm/1554–1880 ppm in the cap of A. pantherina. In the caps, these compounds had a tendency to be more concentrated in the flesh than in the cuticle. On the other hand, the IBO/MUS contents in the stem were far lower than in the caps. In the “extracts purported to contain A. muscaria” products, IBO/MUS were detected below the lower limit of calibration curve (<10 ppm/<25 ppm) or not detected. However, these samples contained other psychoactive compounds, such as psychoactive tryptamines (5-methoxy-N,N-diisopropyltryptamine and 5-methoxy-N,N-dimethyltryptamine), reversible monoamine oxidase inhibitors (harmine and harmaline) and tropane alkaloids (atropine and scopolamine), which were not quantified. This is the first report of the chemical analysis of Amanita mushrooms that are circulated in the drug market.
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we can see that these specimens will have been spiked by some vendor or other, most likely in order for the material to have some kind of effect and possibly for obfuscatory purposes in the case of substances that may be illegal, like 5-MeO-DIPT and 5-MeO-DMT. Also, it's only in extracts "purported to contain A. muscaria" that these anomalous compounds were found.

Bufotenine (that is, 5-OH-DMT) is known to occur in trace amounts in a few other amanita species but, unless you somehow picked up your amanita stems in Japan, you're going to be highly disappointed if you were expecting a cheeky 5-MeO-DIPT dose.

Quantification of these methoxylated tryptamine derivatives from naturally collected material will stand at a resounding zero percent.

This is also an excellent illustration of why one shouldn't just buy random extracts. Both atropine and scopolamine can be lethally poisonous. At least one death has been attributed to 5-MeO-DIPT and the combination of RIMA and 5-MeO-DMT is known to present risk of adverse health events, possibly fatal. It seems likely that the combination of harmine/harmaline with 5-MeO-DIPT would also be dangerous.
 
Thanks vlad, I've never heard of Amanitas being used for pain control before. I use a combo of CBG & CBD from Cannabis infused into MCT oil for pain relief and anti-inflammatory and it one pill a day works great for me. I take more pills if I need more. Sometimes I add in some THC as well. I also make infused balms with THC, CBG & CBD to rub into my back and neck muscles. Works well.

Have you ever tried the grape juice tek with the Amanitas? Sometimes referred to as Sacred Ambrosial Wine.
 
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