Amitriptyline

[2^DqoeHy*97u]

Hi, I hope this is ok, something of a diary page. I've searched the site and only found Amitriptyline mentioned incidentally, no dedicated threads, so given how common the drug is I thought I'd add some actual detailed and measured personal experience for any that might follow.
I've recently come back to DMT after a gap of > 25 years. From back then I have no recollection of ever breaking through, but we were mainly doing it while coming down, mid morning after a night's clubbing, so on the back of often around 1g mdma plus whatever might have come up at the same time [acid, 2-cb, weed, coke, all of what were then common club drugs here in the UK]. I was certainly tripping hard from the DMT though, with all the bright lights and stress of a sub-breakthrough experience. Wake up the next day with no clear memories of anything really, just nights of oblivion.
Older and less stupid this time round it's all change, home grown spice, [and boy am I surprised how well that's gone, I have no concerns about the quality or reliability of what I've made] no other recreational drugs.
I started small, literally a few grains, one hit, max two, in an evening. Increased slowly across about three weeks , got some scales to check small increments, all the way up to 60mg. Pipe, bong, vape, solo, layered, one hit, lots of little ones, all the variations I can find described here and elsewhere.
Almost nothing. At the very high dose I can squint a bit and maybe something which already has a pattern might wriggle about like maybe a small acid trip.
Then I discovered that the amitriptyline I take can have an effect on the efficacy of DMT. I have no knowledge of chemistry or biology so make no claim to proper understanding, but the internet says one's an agonist, and the other an antagonist, of the same receptor.
So I figured taper off and see what happens. It's only for pain, I can manage without for the sake of seeing DMT properly.
100mg Amitriptyline I started on, which is a fairly high prescription dose, but not completely maxed out. I've been taking that for somewhere between 5 and 10 years. I've tapered by 12.5mg per week, a reasonable schedule that has caused me no ill effects. Yesterday, 6 weeks in, I was at a week of 25mg but taken none that day, so in my system was only 12.5mg-ish. I figured try out a 30mg DMT hit and see how far I've come, see what happens. Still nothing.
That's the 6 week stage of my journey. I'll report back in another three weeks when I'm completely clean of Amitriptyline and try again.

 

[2^DqoeHy*97u]

Not three weeks after all. I finally got down to my last 12.5mg dose last Friday so I tried another 20mg DMT dose a day later with approx 6mg of Amitriptyline in my system. Still very little going on, slightly more visual, a second transparent version of a plant in my living room appeared separate from the real one, patterned things wiggled with a bit less of the cross eyes and squinting, but that's about it. Vague patterns closed eyes instantly forgotten once opened again.
I reckon after so many years at a high dose simply quitting isn't going to be enough, more time to wait.
Advice on quitting Amitriptyline is don't do it linearly, reducing by the same amount each week doesn't work and I barely got a proper night's sleep for the last two weeks. Needs to be a percentage each week. Gone now anyway so we'll see.

 

[2^DqoeHy*97u]

This is ridiculous. No Amitriptyline in my system for a couple of weeks and the effect that the DMT is having is identical to that which I experienced when was I was still taking 100mg Amitriptyline / day. Raised heart / breathing rates, mildly warmed mood, mild visual effects with open eyes, a few vague patterns with closed eyes. 40mg Friday and Saturday same both times. Roughly half bong, half vape [set at 200C].
So after months of patient waiting the only conclusion I can come to is that I'm a muppet of some sort and must be doing it wrong. The only unknown is the DMT itself. I followed the A/B method instructions carefully, including accurately measured pH and temps at all stages, and got a off white powder which got a bit sticky on the razor blade as I scraped it from the crystallisation dish. Then I carefully followed the clean-up instructions and ended up with a snow white clean crystal with no stickiness, looks absolutely as I imagined it should. I have a small amount of the sticky pre-cleaned version and that has no more effect.
Now I've read enough here to know that appearance can't be relied upon but, if you follow a procedure and what comes out looks exactly like what's expected, it's hard to see how it could be anything else, so I'm lost.
Any idea what could be wrong with my DMT? Another week or so and this might want a thread of its own somewhere.

 

[TransistorBass]

Just my opinion on Amitriptyline, it can get to F***!
I was put on it for Neuropathic pain and it worked for 18 hours each day, it almost stopped me being able to Pee when getting up in the night, it turned me into an arse hole after a few beers, made me forget things and it made me think I was a better person without Amitriptyline in my system.
Weaned myself off it slowly and now use medical cannabis which give me more than 24 hour pain management on a very small dose with none of the side effects that Amitriptyline gave.

Sorry I'm no use to you on your other points.

Though I do seem to recall reading something about Amitriptyline having contraindications if taken with Mushrooms so I'd advise caution mixing that nasty stuff in with other drugs. And I don't quite recall but it may have been named as a trip-killer in something I read. Do your research, stay safe and alive ;-)

 

[2^DqoeHy*97u]

Just my opinion on Amitriptyline, it can get to F***!
I was put on it for Neuropathic pain and it worked for 18 hours each day, it almost stopped me being able to Pee when getting up in the night, it turned me into an arse hole after a few beers, made me forget things and it made me think I was a better person without Amitriptyline in my system.
Weaned myself off it slowly and now use medical cannabis which give me more than 24 hour pain management on a very small dose with none of the side effects that Amitriptyline gave.

I can't say that I've shared that experience. Best sleep I've ever had, I'm certainly missing that already, it fixed the pain, and nothing too bothersome in the way of side effects. If I end up giving up on DMT I'd probably go back to it were in not for the fact that there has been a new, more effective, alternative introduced in the last few years. That has the same buzz-kill effect though so I'm in no rush.
Weed for that last few years has been a really buzzy rushed sort of affair which gets tiresome occasionally, but I've noticed recently that my weekends have become considerably more relaxed, a much smoother stone. No evidence that that's related to the amitriptyline thing, could just be related to a change of strain, but you never know.

 

[The Traveler]

Interaction between amitriptyline and DMT seems to be minimal, utmost the raised serotonine can be a bit of influence, though amitriptyline itself does not seem to target any of the important receptors DMT might inhibit.

Half-live of amitriptyline and it's metabolites is pretty long, so depending on your tolerance and metabolism, you might have to be off amitriptyline for up to three weeks, to be sure it does not affect your DMT journeys in any way.

As a safety warning: NEVER combine amitriptyline with MOAI, that's potentially a very dangerous combination! Changa which contains DMT also contains harmalas which are a MAOI, so do not smoke changa combined with amitriptyline!


Kind regards,

The Traveler

 

[2^DqoeHy*97u]

Interaction between amitriptyline and DMT seems to be minimal, utmost the raised serotonine can be a bit of influence, though amitriptyline itself does not seem to target any of the important receptors DMT might inhibit.

I've seen this stated often and have been trying to get my head round it. DMT is a 5-HT2A agonist, Amitriptyline is a 5-HT2A antagonist. Does that not imply a clash?

 

[The Traveler]

I've seen this stated often and have been trying to get my head round it. DMT is a 5-HT2A agonist, Amitriptyline is a 5-HT2A antagonist. Does that not imply a clash?

Amitriptyline's binding affinity for 5-HT2A is very weak and clinically irrelevant.

So I only see a complete break with anything for a long time as a need to remedie your body to restore it's original strengths.


Kind regards,

The Traveler

 

[acacian]

I tried amitryptyline a bunch of times.. my housemate had cancer and was prescribed it for pain/anxiety and shared it occasionally. I found it incredibly visual if I could stay awake long enough .. not in the sense of distorting reality so much but I got very harmala-like crystallised visions over the top of everything, that would continue to get more and more detailed if I relaxed my eyes. It was actually some of the most crisp visuals I've experienced beyond the usual candidates.. but it did not feel mind bending. It was also frustratingly sedating to the point that I would be bed-bound for like 30+ hrs. The next day I would just sleep all day and then through the night. That aspect freaked me out.. I truly was a zombie afterwards... terrified to ever sleep that much again. But not at all surprised it affects the strength of DMT it can be pretty trippy by itself.

 

[2^DqoeHy*97u]

Amitriptyline's binding affinity for 5-HT2A is very weak and clinically irrelevant.

So I only see a complete break with anything for a long time as a need to remedie your body to restore it's original strengths.


Kind regards,

The Traveler

Thank you. But to help me better understand, wikipedia says that Amitriptyline is a "potent antagonist of the serotonin 5-HT2A". Am I misinterpreting the word potent in this context?
I'm pleased for sure that you can affirm that time will eventually be the cure.

I tried amitryptyline a bunch of times.. my housemate had cancer and was prescribed it for pain/anxiety and shared it occasionally. I found it incredibly visual if I could stay awake long enough .. not in the sense of distorting reality so much but I got very harmala-like crystallised visions over the top of everything, that would continue to get more and more detailed if I relaxed my eyes. It was actually some of the most crisp visuals I've experienced beyond the usual candidates.. but it did not feel mind bending. It was also frustratingly sedating to the point that I would be bed-bound for like 30+ hrs. The next day I would just sleep all day and then through the night. That aspect freaked me out.. I truly was a zombie afterwards... terrified to ever sleep that much again. But not at all surprised it affects the strength of DMT it can be pretty trippy by itself.

Amitriptyline can be a bit tiring when only tried sporadically, but I've never thought of it as in any way able to produce visualisations or anything so extreme. It does though take weeks to settle and have full effect, with the side effects minimalised. Like I say, I'd been taking it for many years and when I stopped in December I was experiencing nothing worse than occasional drowsiness.

 

[2^DqoeHy*97u]

Oh and I am very well aware of its incompatibility with MAOIs. Next step for me I think will be enhanced leaf to see if that works better as an ingestion method. Minimum another couple of months before I give changa a try.
I'm off work for a week next week which will give me time to carefully explore the methods for making these.

 

[Varallo]

Thank you. But to help me better understand, wikipedia says that Amitriptyline is a "potent antagonist of the serotonin 5-HT2A". Am I misinterpreting the word potent in this context?
I'm pleased for sure that you can affirm that time will eventually be the cure.

Amitriptyline can be a bit tiring when only tried sporadically, but I've never thought of it as in any way able to produce visualisations or anything so extreme. It does though take weeks to settle and have full effect, with the side effects minimalised. Like I say, I'd been taking it for many years and when I stopped in December I was experiencing nothing worse than occasional drowsiness.

I can see the confusion, the “potent” claim is in vitro, and not in vivo, so Amitriptyline is a potent in-vitro 5-HT₂A antagonist but a weak and unreliable in-vivo functional blocker. In the table next to the claim you can see it is about binding affinity, not functional blockade intensity.

Hope this helps.