Hello all,
At our lab, we recently received a synthetic DMT sample that was allegedly made using arclightshroom´s DMT synthesis protocol (I was not familiar with it but this was sent to us by the client)
The sample came in the form of an orange oil. When analysing via LC-MS/MS and NMR, we discovered the sample was 49% freebase DMT, with the rest being mostly a DMT dimer (two DMT molecules joined at the alpha carbon in the alkyl chain), and some traces of beta-hydroxy-DMT
Here are the molecules in question:
The pharmacology of these impurities is obviously unknown, so for harm reduction´s sake, we wanted to advise the user based on some more experiments, whether recrystallizing that sample would be enough to clean the product off the impurities to avoid health risks.
After doing a single heptane recrystallization (as per our FAQ, 1g impure product in 30ml boiling heptane heated through hot water bath, stirring, and then pipetting the solvent away from the undissolved goo, and freeze-precipitating the purified DMT), the product turned to white crystals. We did another quantitative analysis and saw the product´s purity raised from 49% to 97.2%! There was no more dimer nor b-OH-DMT detected in the sample after the recrystalization
Thought this was interesting to share
At our lab, we recently received a synthetic DMT sample that was allegedly made using arclightshroom´s DMT synthesis protocol (I was not familiar with it but this was sent to us by the client)
The sample came in the form of an orange oil. When analysing via LC-MS/MS and NMR, we discovered the sample was 49% freebase DMT, with the rest being mostly a DMT dimer (two DMT molecules joined at the alpha carbon in the alkyl chain), and some traces of beta-hydroxy-DMT
Here are the molecules in question:
The pharmacology of these impurities is obviously unknown, so for harm reduction´s sake, we wanted to advise the user based on some more experiments, whether recrystallizing that sample would be enough to clean the product off the impurities to avoid health risks.
After doing a single heptane recrystallization (as per our FAQ, 1g impure product in 30ml boiling heptane heated through hot water bath, stirring, and then pipetting the solvent away from the undissolved goo, and freeze-precipitating the purified DMT), the product turned to white crystals. We did another quantitative analysis and saw the product´s purity raised from 49% to 97.2%! There was no more dimer nor b-OH-DMT detected in the sample after the recrystalization
Thought this was interesting to share
