Another way of taking DMT

[Morrison1976]

I am sure many of you may have heard about a new delivery system for DMT and 5-MeO-DMT, a nasal gel that was developed by Biomind Labs.

Do you think in the not too distant furture people will get access or knowlege on how to do this. I am talking about normal folk who extract dmt?

This would be a great way to do it.

What are your thoughts on this?

 

[Transform]

Search

forum.dmt-nexus.me

(Shows results for "nasal spray")

 

[Here&Now]

In my experience, nasal absorption of DMT and 5-MeO-DMT is very unpleasant. And even if this company found a way around the discomfort, a gel seems like it could get messy.

Though for those people who don't have access to better options in terms of ROAs, I guess it would be nice for them to gain the ability to partake as well.

 

[Morrison1976]

Cheers for the responses. After a bit of research, yeah, some people have spoken about how unpleasent it is on the nose.

 

[Here&Now]

It wouldn't be my first choice in ROA, that's for sure. But having additional options doesn't seem like a bad thing overall.

 

[Here&Now]

MAOIs need to become more popular. I even feel that psychedelics that don't require them should be used with MAOIs.

Using LSD as a substitute for DMT in ayahuasca

Using mescaline as a substitute for DMT in ayahuasca

One of my goals is to blow the lid on MAOI fears: Understanding the safety profile of MAOIs

That is interesting. I feel like I've mostly only heard of MAOIs being used with DMT, and also sometimes with mushrooms. I never considered mixing them with a phenethylamine, and I would have thought that might even be dangerous, as shown in the chart below. Though this chart probably shouldn't be taken as a gospel truth. They list MAOIs as having a diminishing effect on LSD, which I find hard to believe.

 

[Transform]

That is interesting. I feel like I've mostly only heard of MAOIs being used with DMT, and also sometimes with mushrooms. I never considered mixing them with a phenethylamine, and I would have thought that might even be dangerous, as shown in the chart below. Though this chart probably shouldn't be taken as a gospel truth. They list MAOIs as having a diminishing effect on LSD, which I find hard to believe.

It must depend on the MAOI to some extent. What would moclobemide + LSD be like, for example, versus using, say, phenelzine?

The answer to this would be a case of hardcore mining of the psychonautical reports. Is this what trips/t may have done?

 

[Here&Now]

It must depend on the MAOI to some extent. What would moclobemide + LSD be like, for example, versus using, say, phenelzine?

The answer to this would be a case of hardcore mining of the psychonautical reports. Is this what trips/t may have done?

Yeah, I wonder. They also probably should have made a distinction between reversible and non MAOIs. It's my understanding that harmalas are less able to lock you into an MAO-inhibited condition, which may be the difference between "kind of dangerous" and "very dangerous".

 

[Here&Now]

David Nichols refers to ergoamides (lysergamides) as "rigidified tryptamines". This is a post of mine from another forum:

That makes sense. To me, LSD has subjectively been similar enough to tryptamines that I always just considered it to be one. Though I've only used LSD a couple times, so I don't have a lot of experience to base that on.

I saw in another thread where you mentioned LSA. Any experience mixing that with MAOIs?

 

[Mixer]

I am sure many of you may have heard about a new delivery system for DMT and 5-MeO-DMT, a nasal gel that was developed by Biomind Labs.

Do you think in the not too distant furture people will get access or knowlege on how to do this. I am talking about normal folk who extract dmt?

This would be a great way to do it.

What are your thoughts on this?

Sounds super interesting. I have been doing some reading recently on nasal ingestion recently too. Would love to hear more about it.

 

[Varallo]

Sounds super interesting. I have been doing some reading recently on nasal ingestion recently too. Would love to hear more about it.

I would not recommend it, that said this is a fresh paper on nasal spray DMT.

 

[Mixer]

I would not recommend it, that said this is a fresh paper on nasal spray DMT.

Thanks man. Ill check it out!

 

[blig-blug]

For the nasal route, have people tried using lidocaine first? It's used for headaches so it seems to be reasonably safe, and it should remove any discomfort. Not that I'm planning on doing it, but that's what I would research if I were interested in that ROA.

 

[mudz]

whats it mean by synergy that means it strengthens the effects when both combined
thanks for posting

didn't think cannabis and mushrooms was a bad combo might explain some stuff

 

[blig-blug]

About chronic MAOI intake diminishing the effects of psychedelics, in theory it would make sense through the same mechanism SSRIs do. Could you check what sources 9 and 12 that Ott quotes say? I wonder if they are in humans and, if not, the substances and doses involved. As SSRIs reduce the effects of psychedelics but very much do not completely suppress them in humans, at therapeutic doses.

Then, there's also the fact that some people report here taking harmalas for years and they don't report any reduction in the effectiveness of psychedelics, much less a blocking of the effects.

 

[Transform]

Harmala alkaloids are more complex to analyse in this context, on account of their multiple sites of action, not to mention their nonzero 5-HT₂ₐ affinity. The IC₅₀ is - presumably - higher than many of the psychedelics we're measuring them against, so they can have a modulating or attenuating effect which largely gets obscured by the metabolic (RIMA) action.

Has anyone dug up the figures for how the dose required for a similar effect compares between harmine and the less-complicated moclobemide? Perhaps one of us even has this comparison in their own notes?

 

[Transform]

nanometres (nM, 1×10−9 M),

That's nanoMOLAR. (The symbol for metres is a lowercase 'm'.) So, in the example given, we're talking 10⁻⁹ moles per litre. This represents the equilibrium constant for a dynamic (presumably) 50% active site occupancy.

micrometers (μM, 1×10−6 M)

Again, microMOLAR