Anti-depressants & DMT - IS it possible to experience visuals and breakthrough?

[Plotty]

I'm getting quite despondent about whether or not I will ever breakthrough or even see OEVs/CEVs while smoalking DMT. I have tried about 10 times within 6 months, so nothing desperate, but have patiently given myself time for things to hopefully fall into place without pressure.

Every time I have smoalked, I have experienced the body load, a subtle feeling of being in an altered state and mild transparent layers of "ripples" in my vision, but absolutely nothing like the trip reports of impossible colours and fractals that I've read and listened to.

I could understand that it's quite possible that my tablets (in this case, 100mg Pristiq (Desvenlafaxine)) are directly masking my experience, but I'm not entirely convinced, as I have also read reports from people who take anti-depressants and have no issues with visuals and breaking through.

Is there anyone on dmt-nexus that is in my situation but is able to enjoy the full experience of this wonderful compound? Or is someone able to give me any advice?

Thank you very much. Very eager for your responses!

Most people do not use a technique which lends itself to break-through success. May I ask how you are consuming (specifically)?

 

[Plotty]

Hey there,

i always and everywhere read that Moclobemid and MDMA are somewhat like a safe proof way of "suicidal". I know about the serotonin syndrome but i did that combination 3 or 4 times now. I am taking 300 - 450 mg Moclobemid, depends on how long the day is.

I started with small amounts of MDMA. First time i sniffed 50 mg, if i remeber right, waited untill i had the full effect then heated up my vape and smoked dmt every 10-20 minutes to keep it at a moderate level. After roughly 2 or 3 hours i again sniffed 50 mg MDMA. It was very enlightened and controllable. I sweated aittle more then expected but that was the only thing i recognized.

3. time roughly the same setting but took half a pill of extacy inbetween. While less predictable in when or how strong the MDMA floods the system, i got emotionally extremely intense for rougly 45 minutey ( there can be too much love,... believe me) with sweating like a waterfall but after that 45 minutes ir was all fine again. Nevertheless, pills i most likley wont do again in this setting.

I don't want to motivate anyone taking unnecessary risks with that combination, i am not a doctor but for me this combination is the way to go for now.

I guess its all about the dosis and the awareness of the risk, that can be calculated and minimized if you are responsible with the dosages and stay patient with the onset.

What do you mean you had DMT every 10-20min? It won’t work so quickly after the prior, and if you are using an MAOI you shouldn’t be combining with MD

 

[Plotty]

Being on SSRI, I experience somewhat the same problem: even with high dosis (50 to 70 mg), I only get like 30 seconds of visual overlay, and thats it. I will be getting of the SSRI in march if all goes well, and I plan to wait 6 weeks after that to try dmt again, the reason being that I want my receptors clean, and a few days just is not going to cut it in my experience: I tried like two days of SSRI, then taking oral dmt+maoi ('godlike' dosis), but all I did was purge. Not even visuals. So...

I also am worried about stopping medication. I told my shrink I wanted to do dmt, and he was worried about that, then advised the two days break in ssri (to avoid seratonin overdose). He also told me that I should keep taking the ssri for a full year after my last depression, or it would risk coming back, in which case I would have to take it for like 2 years. Something about rewiring the neural pathways in the brain.

So 'just' stopping medication seems pretty risky. Perhaps you should consult your shrink about it, and get off the medication in a safe manner, then wait another 6 weeks to clean your receptors, and then try dmt. It’s a pain to have to wait, but you cant take risks with your brain. I know a few people that cut their ssri/antipsychotics who then plunged into the deep end so hard. Just my two cents. Wish you all the best.

This challenge will be down to the inhalation technique. You need to refine to a more reliable and effective approach

 

[Plotty]

You mention high tolerance to "narcotics" - I'm guessing this means opioids. (Unfortunately, the pejorative application of this term to include all psychoactive substances that get used recreationally has muddied the original, specific meaning.) Anyhow, it sounds to me as though you may also be a strong metaboliser, especially if you noticed this tolerance before ever having any SSRI,etc., treatment. Some medications also upregulate metabolic clearance, I'd have to check specifically for the ones that you've listed. The upshot is that you may well be deactivating DMT through the CYP2D6 'side route' as well as having downregulation of the serotonin pathway both by competitive receptor blockade and glutamate suppression.

This is my series of educated guesses, at least!

Vapes don’t really work for DMT consumption

 

[Bas Sarkin]

This challenge will be down to the inhalation technique. You need to refine to a more reliable and effective approach

Interesting. Can you describe your method?

 

[Plotty]

Interesting. Can you describe your method?

Copied from other post - In terms of my approach, as mentioned the key requirement is to be able to inhale enough in one breath, even for someone trying it for the first time. To achieve this I use a flower or leaf which burns at super low temperature. I grind this up to an extremely fine powder, like dust (generally I use the vine). I go old school and just use a bong, with a fairly long pipe to ensure the inhale is not hot etc. So using a fairly generous cone piece I test how much a can pack into it. With that super fine powder it is not going to get stuck, so you can put a lot of pressure on it to fill. Empty this amt back out and weigh it, this becomes a standard unit, one cone. Once you have this you need to gauge how strong the DMT is. If the extract is reasonable you kinda want to be able to inhale 100mg, so assuming this is the case I actually want 200mg in that come. If I had a g for instance I would put 5 comes worth of powder in a bowl and dissolve the DMT in ethanol, then mix through and let ethanol evaporate. You now have a uniform mix which is distributed properly through the leaf matter. When you pack the cone there is 200mg available, so what happens in practice is that as soon as the cherry forms there is the bulk of it “vaped” from the heat. It happens super fast. This means that even those people who want to pull out early (as everyone does when it comes to the proper crunch), it is already way too late.