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Anyone tried harmalol?

Migrated topic.
q21q21 said:
edit: hmmm, via further research SWIM found that though it isn't in the US, harmalol is schedule III in Canada.... hope it is for amounts >1g....
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border patrol destroyed it. They considered it "an amphetamine" what ignorant ignoramuses
 
Just ordered 1 gram harmalol. But I have read that it is unstable when exposed to air. Is this a major concern? Will it oxidize very quickly? And what can I do to prevent this.
 
To prevent oxidation, store the material air-tight, without any light, and as cold as possible. Put it in a concealer free of any air, and store it in the freezer. :)
 
69ron said:
Most Syrian rue seeds contain harmine as their main alkaloid, followed closely by harmaline. But this is not always the case. Some Syrian rue seeds actually contain harmalol as their main active alkaloid. Very few places sell harmalol and those that do either charge a fortune for it, or only sell large quantities.

SWIM once had some pure harmalol long ago. He tried it stand alone, and found it sort of resembled psilocybin, but without the visual effects. It was pretty short acting. SWIM did not test it much. It was very pricey. He only had a few doses of it to play with.

Has anyone else had any experience with pure harmalol? Is this alkaloid of any practical use as an MAOI, or potentiator of other psychoactive alkaloids?
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i could be wrong but i think i remember reading that tobacco contains decent amounts of harmalol and norharman(?)
 
Dagger said:
Just ordered 1 gram harmalol. But I have read that it is unstable when exposed to air. Is this a major concern? Will it oxidize very quickly? And what can I do to prevent this.
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Very cool! Are you planning to try it anytime soon?
 
Found some interesting information:
The Alkaloids: Chemistry and Physiology said:
Harmine when heated with fuming hydrochloric acid at 140C gives rise to methyl chloride and a phenolic base, harmol and when similarly treated harmaline produces the corresponding harmalol identical with that found in the seeds of P. harmala.
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Would this be an easy way of producing harmalol and harmol?
 
Dagger said:
Would this be an easy way of producing harmalol and harmol?
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Fuming hydrochloric acid (35+ %) at 140C does not sound easy, this suggests high pressure. Don't boil concentrated HCl without precautions like a fumehood.. from the top of my head: at 1 atm HCl 35% boils at 120C.

The 'ols are very under-investigated indeed Ron! I'm verrry interested in the effect of harmalol on smoked/oral DMT.
 
SWims been asking this question for a long time... this is very worthy of investigation. Harmalol is in a lot of plants as swim recalls... and its true the invasive species russian olive has much in it... Russian olive could be a new and really goo d source for this if its effective and helpful in the great work. There needs to be more effective plants out there that are good at providing the beta carbs... IMHO...
 
Recieved 1 gram harmalol freebase today. Time to test it this weekend.

One concern. How pure are these products bought from chemical companies? Are there a lot of heavy metals or other undesirable compounds. Purity grade of this specific product is 97%
 
That's the problem, and why SWIM has not purchased it. He can't find food grade or USP grade harmalol anywhere, it’s all technical grade as far as he can tell. He can find food grade harmine, harmaline, and THH though. If a vendor has USP grade harmalol or food (FCC) grade harmalol, please let us known about it.
 
Many here would say NO. The amount of impurities present are pretty small, and not likely to cause any problems unless it’s abused regularly.

Some people use street drugs of unknown purity all the time. It’s probably less risky than using a street drug.

I am more paranoid about impurities than a lot of others out there.

Many on this forum have used RCs that boast similar purity levels and are technical grade and they seem to be ok.
 
The impurities are most likely nothing more than you'd find in a typical DMT extraction made using technical grade things like hardware store naphtha, grocery store drain cleaner (sodium hydroxdie), etc.

Is the harmalol synthetic?
 
Just started testing. The crystals is very yellow in colour, turmeric yellow.
I took 50 mg harmalol and added water to it, a bit at a time. It turned very yellow in colour, even though no acid was added to it. That would mean that it is soluble as a freebase. I added a total of 10 ml of water, not everything dissolved. So I tried adding 35% vinegar to it to see what would happen. I added a total of 0.2 ml 35% vinegar. Still there were some particles left on the bottom. It is way more vinegar than I would use to dissolve harmine or harmaline. The weird thing was that the vinegar smell did go away.

I tasted some, both as a freebase and after adding vinegar. As a freebase it tasted bitter, the same when vinegar was added, but it was also somewhat sour.

Another test I did was to add a tiny bit of tannic acid to the solution. It started clumping instantly, just as with the other harmalines. So it does precipitate it, but I am not sure how to remove the tannin later on.
 
It must be a mistake in their data.

When you take rue as filtered tea, it contains a lot of harmalol, and you don't feel anything from it the following day. According to that graph you should, so the graph must be incorrect. I never heard of anyone feeling rue for more than 24 hours.

When SWIM tried what he believed was harmalol, it lasted I think 2 hours? I'm not sure if I remember correctly though.
 
You can read the full article here: Human Pharmacology of Ayahuasca: Subjective and Cardiovascular Effects, Monoamine Metabolite Excretion, and Pharmacokinetics

From the article it looks like harmine is barely detectable in the body, and that it is O-demethylated to harmol. With harmaline it is O-demethylated to harmalol. Perhaps it is weaker? I have heard that some people have had tracers lasting more than 24 hours when taking large amounts of syrian rue. Could it be that the amounts of harmalol has reached a high enough amount to cause tracers? Since the half life of harmaline is more or less 2 hours, you should not have tracers after 24 hours, however much you take.
 
Here is a picture I took of 50mg harmalol freebase.

An interesting observation is that harmalol seems to get a deeper yellow colour at higher pH values.
 

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