I am also thinking about agarikon, lions mane and turkey tail extracts to help with the immunity (yes I am a P. Stamets fan). I gave one of them some mushroom supplements before, but it was the case when I question supplements quality - it was mix of 5 (chaga, maitake, lions mane, cordyceps and reishi).

To elaborate on situation, one of them is suffering close to 4 years, there is multiple tolls its taking which complicates entire situation. Its basically 4 years of antibiotics which I consider terrible by itself.  After 4 years of that ordeal you can imagine the mental state.