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Could micro doses be used as a remedy for the common headache?

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AwesomeUsername

AwesomeUsername

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I don't get a headache often, but when I do it's quite annoying. Seeing as psychedelics in general are cures for cluster headaches, could a micro dose of either acid or shrooms be efficient for the common headache?
 
possibly...(accord. to wikipedia) there are some studies. Not sure if micro-dosing is sufficient, perhaps it might be, once the cycle is broken, micro-dosing might prevent it from re-establishing itself? Do your headaches often occur at a set time...? We don't get headaches, but we get this sometimes.....and it also sucks. (...often triggered by our coffee abuse)






Sun-Edelstein C said:
"Although controversial, the evidence for the use of psychedelic drugs such as DMT, lysergic acid diethylamide (LSD) and psilocybin is worth mentioning for the insight it provides regarding the pathophysiology of migraine and cluster headache. Further research on the effects of these substances may result in a greater understanding of the mechanisms of these headache disorders. ... "
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www.ncbi.nlm.nih.gov

Alternative headache treatments: nutraceuticals, behavioral and physical treatments - PubMed

There is a growing body of evidence supporting the efficacy of various complementary and alternative medicine approaches in the management of headache disorders. These treatment modalities include nutraceutical, physical and behavioral therapies. Nutraceutical options comprise vitamins and...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov

The neurobiology of psychedelic drugs: implications for the treatment of mood disorders - PubMed

After a pause of nearly 40 years in research into the effects of psychedelic drugs, recent advances in our understanding of the neurobiology of psychedelics, such as lysergic acid diethylamide (LSD), psilocybin and ketamine have led to renewed interest in the clinical potential of psychedelics...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
 
No, they are quite rare actually. I'm sure it's not a migraine or a cluster headache, also I don't consume caffeine at all so it's not that either.

I posted this because it has crossed my mind of a potential remedy, not because I have a problem. When it did happen I usually just popped a NSAID, I might as well just as easily sleep it off but I've never done that either so I don't know.
 
The term 'common headache' lacks precision in terms of defining the underlying aetiology which nowadays is fundamental in classifying the headache disorders; the treatment approach varies depending on the aetiology.

Intezams pictures beautifully demonstrate one of the types of visual aura which are seen in migraines.
 
Mushrooms definitely work for my migraines, so long as I catch it early on (too late and I just end up feeling trippy and in pain which kind of sucks).

If you're talking about a stress or tension headache (which I think is what most people are talking about when they talk about general, common headaches), I don't think there's any evidence one way or another.

Visionary doses cause a transient, dose-dependent headache the day after you trip usually, so you might be making it worse, although no one knows.

Blessings
~ND
 
I have been using an e-cig vaporizer to microdose about 1-5mg of DMT. This would enable one to dose when the headaches appear as opposed to predicting when it might happen.
 
Intezam said:
We don't get headaches, but we get this sometimes.....
Click to expand...
(lookup Scintillating Scotoma )

(definitely triggered by GHB)

And I thought I was the only one...;)

I get these often ... I actually like em now.
I call it getting an 'Attack of the Rainbows'

25 minute colourful light show (with some sucky after effects)
Great if you don't mind going Blind for half an hour
Not so great if you're driving ...

Welcome to the Rainbow Club Intezam :)
 
cyb said:
Intezam said:
We don't get headaches, but we get this sometimes.....
Click to expand...
(lookup Scintillating Scotoma )

(definitely triggered by GHB)

And I thought I was the only one...;)

I get these often ... I actually like em now.
I call it getting an 'Attack of the Rainbows'

25 minute colourful light show (with some sucky after effects)
Great if you don't mind going Blind for half an hour
Not so great if you're driving ...

Welcome to the Rainbow Club Intezam :)
Click to expand...

GHB?

It sucks when you are reading....there is also leakage of 'general unease'.

Lol, we used to call them zigzag snakes, before we knew what these were....at first we really thought we was going to be blind :shock: .....as if the retina was peeling off or a similar horror.

We think we have found a way to make it go away (in 5 min): Drinking a large amount of cold water (750ml)....even tho scintillating scotoma is in all loikelihood not related to hydration, but perhaps the cold fluid running down the throat sets off a new kind of response from the brain???
 
Intezam said:
at first we really thought we was going to be blind :shock:

We think we have found a way to make it go away (in 5 min): Drinking a large amount of cold water (750ml).
Click to expand...

Yeah, first time is freaky for sure, I thought it was some kind of seizure.
You feel kinda unwell too.
I'll try the cold water...Thanks for the tip :thumb_up:

Intezam said:
GHB?
Click to expand...
Yeah GHB ( gamma-Hydroxybutyric acid ) ... I know, I'm a fiend. :twisted:
 
Many LSD similar compounds are (were) used for treatment in migraines because of their vassoconstrictive properties via the serotonin-1B receptor, ergotamine tartrate and Dihydroergotamine being some of the most well known...

The mechanism of action of ergotamine is complex.[5] The molecule shares structural similarity with neurotransmitters such as serotonin, dopamine, and epinephrine and can thus bind to several receptors acting as an agonist. The anti-migraine effect is due to constriction of the intracranial extracerebral blood vessels through the 5-HT1B receptor, and by inhibiting trigeminal neurotransmission by 5-HT1D receptors. Ergotamine also has effects on the dopamine and norepinephrine receptors. Its side effects are due mainly to its action at the D2 dopamine and 5-HT1A receptors -Wikipedia
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Another LSD similar migraine medication:
UML-491, Methysergide, Sansert. This is the synthetic homologue of methergine (1-methyl) and is employed clinically as a treatment for migraine headaches. When the usual therapeutic dosage of two milligrams is scaled up by a factor of ten, there is a profound LSD-like response described by most subjects. A number of these ergot analogues from nature can be considered as potential precursors for the preparation of LSD. But here, there is a 1-methyl group that is effectively permanently attached, so it cannot play this role. -TIHKAL;shulgin
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Then there are the "triptans", which are basically a DMT molecule with bulky substitutions off of position 5, (see structures of sumatriptan, rizatriptan, almotriptan, and zolmitriptan) these are used as migraine medications.
triptans mechanism of action: Their action is attributed to their agonist[18] effects on serotonin 5‑HT1B and 5‑HT1D receptors in blood vessels (causing their constriction) and nerve endings in the brain, and subsequent inhibition of pro-inflammatory neuropeptide release, including CGRP and substance P. Triptans are selective agents for 5-HT1B and 5-HT1D[18] and have low or even no affinity for other types of 5-HT receptors. -Wikipedia
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(Picture attached is a sumatriptan molecule)

-eg
 

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EG - triptans (which work very well, I've been Rx'd two) are selective for migraines, and occasionally cluster headhaches. From my review of the literature, I think that the the vascular hypothesis is on it's way out and that it was more to do with inter-regional signaling in the brain mediated by 5-HT receptors, but no one knows for sure.

They're not indicated or other kinds of headaches though.

Blessings
~ND
 
Nathanial.Dread said:
EG - triptans (which work very well, I've been Rx'd two) are selective for migraines, and occasionally cluster headhaches. From my review of the literature, I think that the the vascular hypothesis is on it's way out and that it was more to do with inter-regional signaling in the brain mediated by 5-HT receptors, but no one knows for sure.

They're not indicated or other kinds of headaches though.

Blessings
~ND
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The vassoconstrictive properties are mediated by the 5‑HT1B and 5‑HT1D receptors...

Their action is attributed to their agonist effects on serotonin 5‑HT1B and 5‑HT1D receptors in blood vessels (causing their constriction) and nerve endings in the brain, and subsequent inhibition of pro-inflammatory neuropeptide release, including CGRP and substance P. Triptans are selective agents for 5-HT1B and 5-HT1D[18] and have low or even no affinity for other types of 5-HT receptors.
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Abstract
Recent studies of the pathophysiology of migraine provide evidence that the headache phase is associated with multiple physiologic actions. These actions include the release of vasoactive neuropeptides by the trigeminovascular system, vasodilation of intracranial extracerebral vessels, and increased nociceptive neurotransmission within the central trigeminocervical complex. The 5-HT1B/1D receptor agonists, collectively known as triptans, are a major advance in the treatment of migraine. The beneficial effects of the triptans in patients with migraine are related to their multiple mechanisms of action at sites implicated in the pathophysiology of migraine. These mechanisms are mediated by 5-HT1B/1D receptors and include vasoconstriction of painfully dilated cerebral blood vessels, inhibition of the release of vasoactive neuropeptides by trigeminal nerves, and inhibition of nociceptive neurotransmission. The high affinity of the triptans for 5-HT1B/1D receptors and their favorable pharmacologic properties contribute to the beneficial effects of these drugs, including rapid onset of action, effective relief of headache and associated symptoms, and low incidence of adverse effects. Mechanisms of Action of the 5-HT1B/1D Receptor Agonists
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-eg
 
I once looked into cleaving the 1,2,4-Triazole group from Rizatriptan to yield the DMT core...though I think you would get stuck with 5-methyl-DMT...all though that may not be all bad...

5,N,N-trimethyltryptamine (5,N,N-TMT; 5-TMT) is a tryptamine derivative that is a psychedelic drug. It was first made in 1958 by E. H. Young. [1] In animal experiments it was found to be in between DMT and 5-MeO-DMT in potency [2][3] which would suggest an active dosage for humans in the 20–60 mg range. Human psychoactivity for this compound has been claimed in reports on websites such as Erowid but has not been independently confirmed -Wikipedia
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I have not really looked into sumatriptan, almotriptan, and zolmitriptan as far as cleaving the bulky substitutions from 5 to produce DMT or 5-meo-DMT, or 5,N,N-trimethyl-tryptamine (5-methyl-DMT)...

Structurally I enjoy the triptans as its the DMT moiety that composes their core, their 5-HT receptor agomism and relation the tryptamine neurotransmitters is also interesting, I had not really thought about them for quite some time...

-eg
 
Nathanial.Dread said:
EG - triptans (which work very well, I've been Rx'd two) are selective for migraines, and occasionally cluster headhaches. From my review of the literature, I think that the the vascular hypothesis is on it's way out and that it was more to do with inter-regional signaling in the brain mediated by 5-HT receptors, but no one knows for sure.

They're not indicated or other kinds of headaches though.

Blessings
~ND
Click to expand...

That's an interesting article, however if vassoconstriction is an attribute of 5‑HT1B and 5‑HT1D receptor agomism, and 5‑HT1B and 5‑HT1D receptor agonism helps migraines, then doesn't it seem logical to feel that the vassoconstriction may in some manner be treating the migraine?

There's actually quite a bit more going on than simply vassoconstroction...

These mechanisms are mediated by 5-HT1B/1D receptors and include vasoconstriction of painfully dilated cerebral blood vessels, inhibition of the release of vasoactive neuropeptides by trigeminal nerves, and inhibition of nociceptive neurotransmission. The high affinity of the triptans for 5-HT1B/1D receptors and their favorable pharmacologic properties contribute to the beneficial effects of these drugs, including rapid onset of action, effective relief of headache and associated symptoms, and low incidence of adverse effects. Mechanisms of Action of the 5-HT1B/1D Receptor Agonists
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I can say that I have had migraines where, every time I would lean down, say to tie my shoe, I could feel the blood rushing into my head, causing intense pain, just based off of personal experience I feel that a vassoconstrictive agent could provided some relief to these headaches... but Then again, I'm sure it's fairly complex, and physiology is not one of my strong points...

-eg
 
Excerpt from an erowid link:
Flash's Method for Using Psilocybin Mushrooms to Treat Cluster Headaches
(In Experience Report Vaults)
by Flash

First I eat a large meal, then I wait 2 hours, this prevents stomach upset and excess gas. Next I extract 12 mushrooms (the standard recreational dose is 48) [erowid note: this is done in the U.K. and these mushrooms are psilocybe semilanceata] and add them to a saucepan along with 1 cup of boiling water. I boil the mushrooms for 5-10 minutes (the illegal part) then strain them out and bin them. Next I consume a large glass of whiskey. The whiskey both induces a headache, and eliminates any feelings of apprehension caused by ingesting the Psilocybin solution. Finally I drink the solution slowly, over a 15 minute period, to prevent any disorientation. The mushrooms kick in when the headache is going full blast. There is a sudden feeling of "ooh that's better" and then no more headache. No more headaches for at least 12 months in my case. There are no psychosomatic side effects to speak of, apart from once when I had a giggle fit... Erowid Psilocybin Mushroom Vault : Cluster Headaches Treatment with Psilocybin
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-eg
 
Intezam said:
We don't get headaches, but we get this sometimes.....and it also sucks.
Click to expand...

I had this visual distortion the other day, which is a sure sign I am about to have a migraine. I've only had 4 in my life (all happened this year) and I am taking psychedelics about once every 2 months... not as a result of the headaches however.

They seem to be triggered by bright sunlight.
 
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