Giant Wave of Death: spreading depolarization in severe brain hypoxia (e.g., in clinical death).
Article here:
pubmed.ncbi.nlm.nih.gov
One explanation here:
The DMT project in ischemia/reperfusion injury has been unfolding.
Cheers!
FrEd
Article here:
N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain - PubMed
Dimethyltryptamine (DMT), an endogenous ligand of sigma-1 receptors (Sig-1Rs), acts against systemic hypoxia, but whether DMT may prevent cerebral ischemic injury is unexplored. Here global forebrain ischemia was created in anesthetized rats and aggravated with the induction of spreading...
pubmed.ncbi.nlm.nih.gov
One explanation here:
The giant wave that marks the beginning of the end -- the neurobiology of dying
The human brain is highly sensitive to oxygen deprivation. Extensive and irreversible damage occurs within approximately 10 minutes of cardiac (and hence circulatory) arrest. For the first time, researchers from Charité - Universitätsmedizin Berlin and the University of Cincinnati have been able...
www.eurekalert.org
The DMT project in ischemia/reperfusion injury has been unfolding.
Cheers!
FrEd
