My foaf told me:
"I have battled depression since the age of 9, although it was more phases of meloncholy than full-blown depression. I did have phases of depression when I got older, and got CFS/ME a few years back which was very depressing... to the point where I did contemplate suicide at the peak of my illness and for a while after, though not seriously.
Peruvian Torch helped me stop binge drinking by taking 5g when I went out, to curb the lust for more than a pint or two. Apparently that's used as an antidepressant too. Then I tried ayawaska analog (mimosa/rue). The first time was great and left me walking on air for a week. The second time, a month later, was horrible, an emotional battering that I didn't need as I'm very self aware and all too aware of my problems. I was very depressed for the week following that. The folks on the ayawaska forums will admit that she can be a hard teacher. The purge is not pleasant so again probs not good for severe depression. For this reason, I think ayawaska is NOT good for depression unless you have a hard constitution or loving people to guide you through the process. It would be dangerous for someone severely depressed to get an emotional battering like I did without a wise sitter IMHO. I'd say ayawaska is good for people who are ignoring their subconscious, ignoring their problems, because they will be forced to deal with them, she'll make sure of that. But if you already know that stuff like I did, you're just torturing yourself. I have no experience with microdosing though.
Smoked DMT, on the other hand, has sorted me right out... I feel like a veil's been lifted from my mind, as if my brain's been 'corrected', and I've been good since my first toke. I'm going to smoke it weekly for the rest of my life. It's early days though, so bear that in mind, although I'm confident that I have left my meloncholy behind forever. I have no idea though if some people would get freaked out by the intensity of spice, or if they have a prediliction to mental illness start believing or obeying what the elves tell them. It worked for me, so I'd imagine it works for self-aware people without psychoses or proneness to superstition. However, it could just be that spice was what I was looking for out of life. There's more on how spice helped me in the 'DMT and Health' thread."