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DMT Freebase and Wellbutrin (NDRI)

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Toshido

Toshido

Research & Development
I have a friend (yes it's actually a friend) who takes Wellbutrin and is interested in experiencing DMT free base.

The information online has been pretty generic so far, and I'm more trusting of the people I know here than some random article.

I'm aware that SSRI and MAOI is a bad combo already, and she's not currently interested in Ayahuasca so I don't need to worry about that. But there is nothing for freebase and NDRI on the substance interaction page.

Known Substance Interaction List

But what about Freebase and an NDRI like Wellbutrin? Someone on reddit said they were fine, but again, would rather ask here. Thank you.
 
I'd like to bump this topic. I did see a list somewhere that said Welbutrin + Triptamines are ok together. Any new info, or confirming reports?
 
I'd assume the potential risks of combining bupropion with psychedelic tryptamines like DMT include elevated blood pressure, which could put additional strain on the cardiovascular system, as well as a lowered seizure threshold, both of which are known side effects of bupropion. Adding pro-serotonergic, vasoconstrictive tryptamines would likely only worsen these effects IMO. A sensible precaution would be to implement a small washout period atleast, perhaps coupled with monitoring blood pressure, or even considering an outright switch (5-6 half-lives), if psychedelic therapy is preferred. However, this decision should ultimately be guided by your friend's doctor.

P.S. Not saying the combination is dangerous per se, but most definitely shouldn't be guided by another individual's personal bioassay. I've co-ingested coca leaf along side harmalas and had a blast in the past, would I do it again? or say it's safe for someone else to do, just because there was no percievable harm from the experience? HELL NAHWW!
 
Last edited:
Toshido said:
I have a friend (yes it's actually a friend) who takes Wellbutrin and is interested in experiencing DMT free base.

The information online has been pretty generic so far, and I'm more trusting of the people I know here than some random article.

I'm aware that SSRI and MAOI is a bad combo already, and she's not currently interested in Ayahuasca so I don't need to worry about that. But there is nothing for freebase and NDRI on the substance interaction page.

Known Substance Interaction List

But what about Freebase and an NDRI like Wellbutrin? Someone on reddit said they were fine, but again, would rather ask here. Thank you.
Click to expand...
Wellbutrin suppresses glutamate production which is necessary to Experience psychedelics.
 
Keith4sure said:
Wellbutrin suppresses glutamate production which is necessary to Experience psychedelics.
Click to expand...
This is the sort of statement that looks far better when supported with some proper references ;)

pubmed.ncbi.nlm.nih.gov

Inhibition of glutamate release by bupropion in rat cerebral cortex nerve terminals - PubMed

Central glutamate neurotransmission has been postulated to play a role in pathophysiology of depression and in the mechanism of antidepressants. The present study was undertaken to elucidate the effect and the possible mechanism of bupropion, an atypical antidepressant, on endogenous glutamate...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Ketamine and the next generation of antidepressants with a rapid onset of action - PMC

Existing treatments for major depressive disorder (MDD) usually take weeks to months to achieve their antidepressant effects, and a significant number of patients do not have adequate improvement even after months of treatment. In addition, ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
www.nature.com

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin - Neuropsychopharmacology

There is growing interest in the therapeutic utility of psychedelic substances, like psilocybin, for disorders characterized by distortions of the self-experience, like depression. Accumulating preclinical evidence emphasizes the role of the glutamate system in the acute action of the drug on...
www.nature.com www.nature.com

Welcome to the Nexus!
 
A few more refs, very interesting field of study:
www.nature.com

The neurobiology of psychedelic drugs: implications for the treatment of mood disorders - Nature Reviews Neuroscience

In this Perspective, Vollenweider and Kometer discuss the clinical potential of psychedelic drugs for the treatment of various psychiatric disorders, and describe the molecular mechanisms by which classical hallucinogens and dissociative anaesthetics affect serotonin and glutamate systems. An...
www.nature.com www.nature.com
molmed.biomedcentral.com

Effects of psychedelics on neurogenesis and broader neuroplasticity: a systematic review - Molecular Medicine

In the mammalian brain, new neurons continue to be generated throughout life in a process known as adult neurogenesis. The role of adult-generated neurons has been broadly studied across laboratories, and mounting evidence suggests a strong link to the HPA axis and concomitant dysregulations in...
molmed.biomedcentral.com molmed.biomedcentral.com

Psychedelic Targeting of Metabotropic Glutamate Receptor 2 and Its Implications for the Treatment of Alcoholism - PMC

Alcohol abuse is a leading risk factor for the public health burden worldwide. Approved pharmacotherapies have demonstrated limited effectiveness over the last few decades in treating alcohol use disorders (AUD). New therapeutic approaches are ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
 
Transform said:
This is the sort of statement that looks far better when supported with some proper references ;)

pubmed.ncbi.nlm.nih.gov

Inhibition of glutamate release by bupropion in rat cerebral cortex nerve terminals - PubMed

Central glutamate neurotransmission has been postulated to play a role in pathophysiology of depression and in the mechanism of antidepressants. The present study was undertaken to elucidate the effect and the possible mechanism of bupropion, an atypical antidepressant, on endogenous glutamate...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Ketamine and the next generation of antidepressants with a rapid onset of action - PMC

Existing treatments for major depressive disorder (MDD) usually take weeks to months to achieve their antidepressant effects, and a significant number of patients do not have adequate improvement even after months of treatment. In addition, ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
www.nature.com

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin - Neuropsychopharmacology

There is growing interest in the therapeutic utility of psychedelic substances, like psilocybin, for disorders characterized by distortions of the self-experience, like depression. Accumulating preclinical evidence emphasizes the role of the glutamate system in the acute action of the drug on...
www.nature.com www.nature.com

Welcome to the Nexus!
Click to expand...
Yes thank you. The following are quotes from a published and trusted Neuropharmacologist friend of mine:
Wellbutrin lowers glutamate release which is crucial for psychedelic effects
So it will blunt psychedelic
As well as turning your trip into a trainwreck trip via nicotinic receptors antagonism
It's a powerful nicotinic receptors antagonist
Lamictal will inhibit your trip
Lamictal lowers glutamate as well
Rexulti is a dopamine receptors antagonist so it will make your trip much more likely to be negative
Psychedelics work through 5HT2A receptors agonism which leads to mGluR2 inhibition and significant glutamate release
Without glutamate, you can never trip
NMDA receptors are autoreceptors for glutamate. This means when you block NMDA receptors with PCP or Ketamine or something, they actually RAISE glutamate release which further stimulates other ionotropic and metabotropic receptors
This is why you can, for example, have a psychedelic trip on Ketamine.
If you use SSRI antidepressants they will significantly blunt MDMA.
 
Keith4sure said:
Yes thank you. The following are quotes from a published and trusted Neuropharmacologist friend of mine:
Wellbutrin lowers glutamate release which is crucial for psychedelic effects
So it will blunt psychedelic
As well as turning your trip into a trainwreck trip via nicotinic receptors antagonism
It's a powerful nicotinic receptors antagonist
Lamictal will inhibit your trip
Lamictal lowers glutamate as well
Rexulti is a dopamine receptors antagonist so it will make your trip much more likely to be negative
Psychedelics work through 5HT2A receptors agonism which leads to mGluR2 inhibition and significant glutamate release
Without glutamate, you can never trip
NMDA receptors are autoreceptors for glutamate. This means when you block NMDA receptors with PCP or Ketamine or something, they actually RAISE glutamate release which further stimulates other ionotropic and metabotropic receptors
This is why you can, for example, have a psychedelic trip on Ketamine.
If you use SSRI antidepressants they will significantly blunt MDMA.
Click to expand...
ty this is great for me. i was on abilify, remeron and still lamotragine (lowers glutamate) adderall and clonazapam. like the cautious person i am i cold turkeyd the abilify and remeron and titrating down the lamotragine. just bought a high quality supplement with l tyrosine, glutamine and 5htp today to kick start those chemicals. started off nn a few months ago with some success and sub breakthroughs but slowly getting less and less to nothing on up to 200 plus mg of spice. been researching the glutamate last few days and this makes sense from all i've read from reputable sources. thanks for the post and info
 
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