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DMT in Plants

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I agree with both of you endlessness and bufoman. What I meant about plants is that they are not thinking in the same way we are and they are not self aware in the same way we are. Because yes you both are right that consciousness could be something beyond matter for reasons we covered in reality thread and thus everything could be a manifestation of consciousness. But that is not directly related to the point I am making.

as for the 'what are the alkaloids for', I think that the 'insect protection' explanation might be true but not the whole truth. Alkaloids might have a variety of purpouses. Whether one of them is to form symbiotic relationship with other lifeforms through the high they provide or if thats 'accidental', I dont know, but definitely it gives them some sort of evolutionary advantage due to it, now with us humans cultivating them.

Yes again I agree, although the only thing I am not sure about is a symbiotic relationship through a psychoactive effect, and I will explain why.

There are many explanations why plants make these compounds that are valid and let me just touch upon some of them. Alkaloids and other secondary metabolites are closely connected with the organisms that a plant interacts with. For example symbiotic relationships with bacteria and fungi involve a host of chemical signals. Likewise pathogens elicit a variety of chemical responses by a plant. Also realize that it costs the plant energy to make these compounds so often they are not making them in relatively high levels for no reason. If a plant was just endlessly making some high level of alkaloid that had no activity in its environment and its neighbor didn't make it or need it its neighbor is going to out compete it because its neighbor is going to focus on growing and making seeds (this kind of thing has been shown and proven many times).

But the main issue is the plant doesn't think about any of this. Its all genetically and environmentally controlled. This has been and still is being proven over and over case after case. Even in very specific close relationships in a way its an accident of evolution.

A plant has no way of knowing that any compound it makes will be biologically active against or for something in its environment. It has no way of knowing whether or not the compound it made is working all it knows is its trying to produce seeds without getting killed. Plants evolved to make these compounds first (and still) by random mutations in their genes and metabolic pathways (as well as a few other mechanisms that I won't get into such as gene transfer etc etc). Now plants that just make a bunch of compounds that are useless will not survive because they are wasting their energy on making them. So everytime a plant made a useful compound it survived in its environment and thus it can persist. That is why we have so many plants producing thousands of different chemical compounds all across the world. That is why some plants on totally different sides of the world evolved to make some of the same compounds. It all has to do with biosynthesis and how biosynthetic pathways change and evolve based on the environment and selection pressure being put on the plant.

Let me explain now why the argument that this compound may be involved in some kind of deep relationship with humans is more on the human end and less on the plant end. Its on the human end because it effects us sometimes in a very positive way. Thus we like it. But humans are not exerting strong enough selection pressure on many of these plants to force them to make this compound for us.

Lets make up an imaginary situation to show that it can be dangerous for a plant to make too much of a useful compound. Imagine a group of humans living on an island. On that island is a plant that gets them high but provides no real nutrional benefit. Lets now assume these are dumb humans and did not cultivate the plant. Now lets say the humans have plenty of other food from fruit trees etc. So the human sais I want to get high I'm going to eat this plant. As more humans come into the picture and eat more and more of this plant to have fun and get high less and less of that plant is going to be around. Again we are on an island with a growing human (dumb human) population who is eating more and more of this plant that gets them high. Now the only plant of this species that will survive this human rampage is the plants that make less of the compounds that get the humans high. Humans will then ignore those ones and eat the goods ones.

THIS HAPPENS WITH ALL LIFE ALL THE TIME! That was a crude made up example but you can observe this with insects in the field and many many many other situations.

Sorry for long post but I hope people see the big picture. Its not all about us.

Maybe not, but in any case I still see the symbolic and practical validity of one having a 'plant spirit' experience and transforming that into action, into being more respectful and friendly towards other life forms such as plants

I agree these experiences can make people more friendly towards life. But plants don't care about other life that doesn't benefit them. They only care about making seeds and surviving. Weeds don't care about ripping a garden to shreds with toxic chemicals and killing everything around it. But the main reason I don't really see the evolutionary advantage is that after you eat the plant it has no way of telling its offspring that this works and that they should keep doing it. The only way those traits get passed on is if the plant survives. If we are eating the plants reproductive organs it makes less and less sense.

But yes the plant could have made a compound that in a way makes us like it and breed it and this does make it an evolutionary advantage! And in those kinds of situations your totally right but the point is the plant isn't thinking about it that way. All the plant knows is that its alive and whatever its doing seems to be working.
 
burnt said:
Why all the supernatural explanations? DMT is a perfectly normal compound. Plants make it to deter most organisms away.

Where have you got that information from? Is it toxic to animals?
 
Studies show that controlled injections of pure DMT, at human recreational doses, kill sheep. Why sheep and humans respond differently to DMT is still an open question here. It may be that it is not an important question, but the possibility of human death on phalaris still looms.


I would like to see the reference for where they actually injected sheep with pure dmt and I think I have looked at it before but if anyone can find that study it would be great.

But again remember this is a specific case and doesn't apply to all things. Sheep are grazing animals so plants that live in grassland have to adapt to them by either killing them/detering or using them/manipulating them. A plant growing in the jungle is going to be in a much different situation with many different types of things trying to dig into its root bark etc. I don't think anyone has studied that specific example at this point.
 
Yes, if humans like a specific attribute of a plant they will select it and grow it for that purpose. Or they will inadvertently spread its seeds from contact. You are giving a very specific unlikely situation. i am not saying that the plant knows what it is doing, this is just what happened why it evolved is not known, mutations as we currently understand them, have no reason they just happen they may or may not benefit the organism (and they may also be negative). But the fact that some plants get us high has secured the survival of these plants as long as we are around. Plants do have to take energy risks to survive. If they didn't they may not survive. You are assuming a low energy system but there are high energy environments and environments that require chemical protection for survival. Again it all depends on the specific situation. The very fact that some plants have high alk contents shows that at some point they took the risk and it favored there survival they out competed there brothers and sisters without the alkaloids. Now why does the level of alk increase? When does it stop? DNA tries everything until it gets it right. It has to use some energy, nature has shown us that the risk is worth it in the long run. Also with plants there are greater chances for variability because of the number of seeds. Take the risk with a few seeds but keep most normal... There are many tricks to evolution.
 
Tryptamines kill insects as they use amines like we use acetylcholine to control motor function. Some alkaloids may not be psychoactive but are present becasue they have a bitter taste which deters animals form grazing. There are many possibilities. You have to look at the specific environment.
 
Quote:
Studies show that controlled injections of pure DMT, at human recreational doses, kill sheep. Why sheep and humans respond differently to DMT is still an open question here. It may be that it is not an important question, but the possibility of human death on phalaris still looms.

DMT has not been shown to cause staggers or death in sheep this is speculation resulting from phalaris grasses causing this. The pure compounds do not have this effect see trouts notes. It likely is a result from pharmacological interactions between multiple alkaloids.
 
Yes exactly I could get into more details complicated examples but its not necessary here. The overall point for those who have not read all the details is the fact that these compounds are in plants makes perfect sense within our current evolutionary models.

Thanks for clearly that up about the sheep story bufoman. I too thought it was flawed and that they never actually took dmt and shot up the sheep with it and watched it die. None the less if the sheep trips balls it may become a deterant. Many animals don't like tripping like humans do. They may like alcohol and some other substances like those bears in australia that eat eucalyptus but most animals get scared shitless if they trip out. I really don't know which ones do and which ones don't but I am sure everyone knows some idiot who gave their dogs shrooms or something dumb and messed it up big time. We are one of the few species that some of us like feeling like we are about to die over and over again 😉


Anyway DMT does have an LD50 in mice. But do mice have monoamine oxidases? I have no clue. But dmt can kill a mammal in high enough doses. That doesn't mean its made to deter mammals however..

Basically dmt has not been studied much in an ecological context but I am sure the deeper one looks with well thought out studies the more roles one will find.
 
check out intoxication by Seigal. Some animals hated DMT but others loved it. They are like humans where some like it some don't. it is a great book and talks all about animals becoming intoxicated. Even insects seek out mind altering plants...
 
Insects may be seeking out mind altering plants for a reason known as the "specialist generalist delima" Basically if an insect is immune to a strong chemical compound it actively seeks out that plant because it knows it can handle it and othesr can't. Basically the insect may seek plants for evolutionary reasons that contain such compounds not because they are getting high off it. But in some cases they may be getting high and seeking some kind of rush much like we do.

But sounds like a cool book. Damn bufoman your giving me a huge reading list here slow down 😉
 
hahha I love reading man. My place is covered in books. That is a great one though man. Check it out. Also insects store toxic chemicals that they are immune to. Poison dart frogs do this as well. The toxins are from the environment and are used to protect from predators.
 
Man, what a long discussion!...only been a day.

Swim thinks burnt said it mostly. Glad someone cleared up the image of a plant "wanting" to stick around. The only reason they're around is because the other versions died off, and it's the environment's fault. SWIM doesn't really see DMT adapting with humans since humans weren't around long enough to trip off of DMT. Makes sense that DMT is found everywheresince it's a simple compound, but what about monster molecules like the Salvinorins? It doesn't seem to affect humans or any other animals really unless taken in massive quantities? SWIM also hasn't read any papers on its interactions with other plants. That seriously is a pretty crazy genetic mutation...to produce those molecules.

On the other hand, wiki says that Salvia Divinorum might be a true cultigen...in other words, it already died out.

E.C.
 
btw I have a question, maybe burnt or someone can answer,

plants are known to tell others about predators/threats through different kinds of chemical messages, root-root communication, etc.. This would make sense for plants telling others of the same species (natural selection and all).. But are there cases of plants of different species communicating with each other?
 
Ethnochemist: Evolution does not necessarily have a reason that is what we have been saying. It does things randomly if it happens to benefit the organism it is favored and continues on. Thus things like alkaloids will always exist that have no benefit, so long as they don't hurt the fitness of the organism they may stick around (some energy has to be risked to allow for adaptation). Nothing evolves for a specific reason, plants don't make the chemicals thinking that it will be used for this or that, they just make them and if it works it will be favored if not it won't. So you can't say why a mutation evolved but you can say why it is still around. The reasons it is favored can also change with time. THC may have initially been favored to protect the plant from insects but now cannabis is surviving because it gets humans high and we cultivate it. The environment is dynamic and thus so are the reasons, this is what nature is all about adaptation. Also some alkaloids are just metabolic by products, the plants use these chemicals to get rid of waste (chemcial groups) that would other wise be damaging to them. SO there are many many reasons they do not all involve psycho-activity. Bitter taste is another, or protection from radiation.... it goes on and on.
Plant Communication:
Not exactly
it seems they can influence each other based on the environment but to what extent it is not that well known. It is not a fast communication and requires diffusion and root to root interactions involving hormones and chemicals. It also may involve bacteria and fungi "communicating" with plants. But it is not regarding predators and things of a quick nature. There are huge networks of underground root systems, check this stuff out it is pretty incredible it is like an ecosystem diff plants exchange nutrients, and hormones and have a crazy symbiotic relationship going on. Mycelial Fungi act as the bridges in many cases.
 
Yes swim understands that, that's not why he's asking. It take energy to make these chemicals, no? If they don't serve any purpose, why didn't the plants without these alkaloids survive? Is it because the energy to make these chemicals is so small that it didn't affect he fitness of the plant?

E.C.
 
Yes SWIM understands that, that's not why he's asking. It take energy to make these chemicals, no? If they don't serve any purpose, why didn't the plants without these alkaloids survive? Is it because the energy to make these chemicals is so small that it didn't affect he fitness of the plant?

It depends. One strategy is to make lots of different compounds and hope (not that the plant is thinking its just doing) that some work. So some very complex pathways are out there. For example think of an essential oil of any plant can contain up to 50-100 compounds but maybe only one or two of those compounds are strongly active against a specific pathogen. The other compounds may not be useless though because lets say they keep new pathogens away or some of them attract pollinators etc. Its all a give and take. Sometimes plants who are wasting resources making too many compounds get out competed by plants that don't need them to survive because they have some other mechanism. Sometimes plants making too many of a specific compound are actually attracting a pest or the other way around. Its all a balance that flips back and forth.

plants are known to tell others about predators/threats through different kinds of chemical messages, root-root communication, etc.. This would make sense for plants telling others of the same species (natural selection and all).. But are there cases of plants of different species communicating with each other?

Yep for example if a plant is under attack by a insect it can release a chemical signal into the air and other plants even of different species can pick up that signal and start to prime their defense system. This is another concept which we have not touched upon but plants can go from making no compound to making lots of compounds depending on some of these signals. Often when humans take plants and try to grow them in perfectly sterile cell culture environments with all their nutrional needs met the cells suddenly stop producing all the compounds the humans wanted to harvest and then you have to trick the cells into thinking they are under attack with the same chemical signals. Methyl Jasmonate which is in a lot of perfumes is one of these very important signalling compounds.
 
no disagreements on what has been said about why the plants create these chemicals but do u not think that all this is based on our western way of looking at the world and assessing it. tribes may be primitive in our eyes but to them we must seem like total parasites sucking the earth dry and polluting it so badly that the quality of our lifes is badly affected. How about trying on their eyes, seeing things differently - after all everything is just an opinion and what was mentioned above is based on years and years of opinions built on opinions - too much abstraction takes one away from what is actually being assessed. why must my truth be skewed by others ? dunno if i got across what i meant to. :(
 
I see what you are saying. But its not based on opinion its based on facts this has nothing to do with how I think it works or how some scientists 100 years ago thought it worked, its how it does work. Its how evolutionary mechanisms made all this possible and how science has unraveled some of these biosynthetic pathways and their evolutionary origins. These are facts not opinions. Is there more going on then what science has so far figured out? Yes most likely and science will continue to unravel more and more examples of why these compounds are present in plants.

But now if we look at it from a tribal point of view I think they have some valid claims. However I also think they are locked into cultural traditions and belief systems that are valid in a healing and ethnobotanical sense but may not be valid in an evolutionary context. By that I mean these plants and compounds from them are used in a medicinal system developed by these cultures that does work for them and even works for westerners seeking alternative medicines. But often their stories and myths for why these compounds (or effects rather because they didn't know about compounds) are there are just that stories and myths made up by a culture who had no other way of knowing what was going on within these plants. That doesn't mean they are dumb or backwards or un-interesting but it needs to be looked at in the cultural context from which their beliefs were formed.

However they do have a lot to say about living in balance with nature and that is something I think westerners can benefit from. I don't think that knowledge comes necessarily from the plant's drug effects but more from the knowledge that human beings depend on plants and balanced ecosystems, something these tribes know very well. But realize its not a west vs. traditional culture because modern science is saying the exact same thing that we our screwing up the balance in ecosystems all around the globe and polluting the heck out of everything. People who know this both in the west and in traditional cultures have more in common then they may think. We just use different language, science, myths, stories religious beliefs etc and cultural belief systems to describe this situation. I consider Shamans scientists they spend a long time figuring out what combinations of plants work for what illnesses. They may have different cultural beliefs then me but their system does work.
 
i think u missed what i was trying to say - look at the bigger picture - there is no such thing as a fact in the true meaning of the word - science is just a structure to explain things by, what if one day something happened that turned everything around, our view was no longer valid.
a couple hundred years ago we knew the world was flat and according to the most advanced science of that age it could be proved, that changed.
See what im trying to get at here ?
 
Yes but what you are saying belongs in the realm of metaphysics and philosohpy. To say that nothing is really a fact while yes in some philosphical sense is true but in some ways is completely rediculous. If you look at all things like that you can discount anything anyone sais based on nothing but a philosphical argument that in most cases in the real world is meaningless.

a couple hundred years ago we knew the world was flat and according to the most advanced science of that age it could be proved, that changed.

Yes some cultures "thought" it was flat but it was proven to be round not by some philosphical argument but because it is round thus it is a fact that the earth is round. Now I can apply your same raesoning that nothing is truly a fact and say but is it really flat because all reality is an illusion or something but that is just stupid.

You are right though that science is a way of explaining things but look chemicals and molecules are real in the sense that we can observe them. This is never going to be disproven by anything, except if we turn to the argument that all reality is just information (see reality thread) from a quantum mechanical point of view but that doesn't matter for what I am saying. We can see them we can measure them we can break them apart and put them together. We can study things at the molecular level we can study things at larger scales. We can prove things. People need to start realizing that science works its not some made up bullshit like religion.
 
yeah but there is no way to actually see an electron is there? we have decided thru science how these things behave thru observation and made theories about how they look - perhaps were wrong on many things but we cant see it to prove it.

I get what u mean dude - i guess it does lay in that region and i guess im more into that side.
i Enjoyed this conversation. shot.
 
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