Dmt interaction with lamotrigine and how to discuss dmt usage with a psychiatrist

[tegetege]

Hello im new here. Im being dealing with depression for 4 years now, i have tried different meds but my depression is resistant to therapy and meds, my first psychiatrist wasnt good at all, she wanted to give me a virtual session because she was paranoid about gettin’ exposed to covid so she only attended me via videocall and gave me desvenlafaxine.
after 4 months of just gettin worse, i got an appointment with a better psychiatrist and he added Lamotrigine to my treatment, it worked and i started to get better until i got a big relapse a year later due to my ex leaving me and some nasty work environment violence i was victim, at that point i was starting to lower my desvenlafaxine dose.
Due to the relapse, he increased the desvenlafaxine again, however this time it wasnt working so he shifted for venlafaxine as it is “the same but more aggresive” and he also gave me a little dose of quetiapin because i have a strong sleep disorder and i wasnt being able to control it. However it didnt work at all and i spiraled deeper into depression until i was close to a suicide attempt, It was fucking horrible… and all he did was just nuking me with a higher dose of all that shit.
So this february i went to see another psych, that old guy is the best doctor i have ever met, and he suggested me and my mom to take a genetic test to see wtf was going on and i got a disgusting surprise but everything came into sense… my body doesnt metabolize correctly both venlafaxine and desvenlafaxine, im just and unlucky guy.
The test showed that Bupropion was, genetically, a good option for me so we started the switch which it was fucking hell to me. Now Im currently with only bupropion and lamotrigine, as he also told me to ditch the quetiapin.
Im better now but im still having a really slow recovery, so a friend of mine suggested me trying dmt with a really nice guy who had helped him and his familly, so i decided to give it a try. And for surprise of no one, i liked it lol.
This medicine is in the really small list of good things that had happen to me during these last 4 years lol
My traditional therapist is already aware about my dmt therapy and he agrees with it as long as i make sure that its not dangerous, however, before i was going to discuss about dmt with my psychiatrist, HE FUCKING DIED (yeah, im not a lucky guy) it was one of the toughest griefs i had ever had, he was a really nice guy and an excellent doctor.
I’m meeting my new psych this friday and im a biologist but a very ignorant one lol, i have been looking for some good documentation about drug interactions and i found that i cant do ayahuasca because the MAOI compounds in the brew are dangerous with psychiatric meds, but its not dangerous to mix smoked dmt and bupropion, however i have not found anything on lamotrigine, so i would be grateful if anybody has some nice documentation about this DDI to share.
I want to be as best informed as possible because i dont wanna hide any information to this new guy, today i had my third dmt session and it has helped me a lot, i was pretty skeptical about psychedelics but now i believe in them strongly. In my experience with my 3 past psychs, they are careful with changing meds, but i also want to be sure that if for a strange and unlikely reason he doesnt like bupropion, he does not give me a different med that is potentially dangerous with dmt.
Thank you very much in advance, any advice will be deeply appreciated, also sorry about my long tragic story just to ask for some DDI information, but i think context can help you to give me advice about what to tell the new guy

 

[esoterickal]

I would encourage to just stop your antidepressants for 2 weeks leading up to your trip. I have done it twice. You're off the effexor and that's the tough one. The remaining two should be petty painless.

 

[Transform]

Hi there and welcome. That all sounds rather challenging.

Lamotrigine looks fairly horrible by itself! Examining the data for both that and bupropion, it appears you ought to be cautious how you go about reducing the dose of those two. Bupropion carries a risk of seizures, while lamotrigine has anticonvulsant properties.

Your story makes me wonder how your nutrition might be. B vitamins are important for neurological health and I see that lamotrigine mildly inhibits dihydrofolate reductase. It's also quite easy to imagine that motivation towards a healthy diet might be difficult in a severely depressed state, so I'd be interested to know how you're doing with diet and exercise.

It's these kinds of systemic changes that will underpin your journey towards health. Relying on medication may only bring you so far - that may even include DMT. The change of perspective it brings, not to mention its proven action of neurological repair, will still require integration in the form of a healthier lifestyle.

In that vein, it's sad to hear of the loss of the person who was helping you. In the broader picture, it's another life lesson - isn't your goal in some way to be standing on your own to feet through all of this?

 

[Voidmatrix]

Greetings,

A Resource: Detailed Account of Depression

Preface: This is going to be pretty long... and not a ray of sunshine... There are a few purposes to this very long post. First, to help those who do not experience clinical depression to understand somewhat what the experience can be like in order to spread awareness, and so that those who do...

forum.dmt-nexus.me

The above thread is shared so that you know you're heard, felt and not alone.

Secondly, I'm so sorry to hear about your struggles and poor swing of luck in these affairs. If anything, these hang-ups are tests of a sort, and should be looked at as such. Will you pass? Never give up, and you likely will, even if it's not in the way in which you were expecting.

I was able to find this, which can get us started on what we want to know.

Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports

Thieme E-Books & E-Journals

www.thieme-connect.de

One concern with the MAOIs is with regard to inducing serotonin syndrome through mechanisms of actions starting in the gut where some serotonin is catabolized by MAO when no MAOI is present. When on any SSRI, there is more serotonin in the system, and with MAOIs that much more and the reuptake is inhibited.

While DMT is serotnergic, it does not produce serotonin on it's own, but rather, binds to the same receptors and certain flavors of serotonin.

One love

 

[Jungleheart]

I've experimented with psychedelics while on various medications, including Lamotrigine. However, I made it a point to avoid combining psychedelics with Wellbutrin. Wellbutrin acts as a stimulant, and in my experience, it can feel like a very mild dose (around 1/32 of a bump) of cocaine. My concern is that Wellbutrin could potentially contribute to serotonin syndrome when paired with psychedelics, and I wouldn’t rule out that possibility.

From my experience, Lamotrigine is relatively benign in terms of side effects, so not the worst one to be on. And the skin rash can be avoided if you titrate slowly (I know how anguish enducing that can be).

Unfortunately, I’ve found that I need some kind of support for my mental health, based on extensive experimentation. Currently, I seem to have success managing stability with daily oral harmalas. My routine involves taking 30-50mg of harmalas twice a day, which seems to keep me balanced without the need for pharmaceuticals. That said, this approach is something I have to monitor closely to ensure it continues to work for me, especially when I'm under stress.

I don't discuss psychedelics with doctors because I'm concerned about it going on my medical record and impacting insurance. I would be more willing to tell a private psychologist or therapist about that. If you are that close to suicide, I would recommend saving up and maybe going to an ayahuasca retreat in the Amazon. It seems the fastest way to turn things around.

What saves me is realizing that my favorite people are those who have persevered through hardship, not the people who have had easy lives. And that it is possible to heal from the worst traumas imaginable, people do it all the time. My personal motto is "never give up!" You can definitely build a healthy life from a broken state. Harmalas and ayahuasca are essential to me, but you have to find the tools that you work best with and can build a relationship with.

If you're interested in more about my journey with mental health, check out my "Learn From My Mistakes" post (linked in my signature). I also suggest reading The Jungleheart Protocol, as a method for integrating harmalas with self care to get to the root of depression and mental illness.

Please feel free to keep us updated on your journey!