flyswatter
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Do other substances effect or block the trip of dmt
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- Thread starter flyswatter
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Phenethylamine23
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Chat GPT is your friend.
From chat GPT.
Do other substances effect or block the trip of dmt?
Yes, several substances can affect or block the effects of DMT. These include both physiological and pharmacological factors. Some substances can dampen or completely block the intensity of a DMT trip:
1. Monoamine Oxidase Inhibitors (MAOIs):
Without MAOIs: DMT is rapidly broken down in the body by the enzyme monoamine oxidase (MAO), especially when taken orally. This is why oral DMT usually has no psychoactive effect unless taken with an MAOI, like in ayahuasca brews.
With MAOIs: Substances like harmine, harmaline, and moclobemide inhibit MAO, allowing DMT to remain active in the body for a longer time. MAOIs extend and intensify the DMT experience.
2. Serotonin Receptor Blockers (5-HT2A antagonists):
DMT primarily interacts with the 5-HT2A receptor, which is crucial for its psychedelic effects. Serotonin antagonists or 5-HT2A receptor blockers can diminish or completely block the effects of DMT. Examples include:
Antipsychotic medications like Risperidone, Olanzapine, and Clozapine.
Trazodone or Mirtazapine (antidepressants that affect serotonin).
3. Selective Serotonin Reuptake Inhibitors (SSRIs):
SSRIs (e.g., Fluoxetine, Sertraline) might dull the effects of DMT due to the modulation of serotonin levels, although the effects are not as pronounced as with direct serotonin antagonists.
People on SSRIs may report diminished psychedelic effects, but not complete blockage.
4. Benzodiazepines:
Benzodiazepines (e.g., Diazepam, Alprazolam) can dull or reduce the intensity of a DMT trip. They work by calming the central nervous system and reducing anxiety, which can lead to a more muted or less immersive experience.
5. Alcohol and Other Depressants:
Alcohol and other central nervous system depressants can blunt the overall effects of DMT by inhibiting its psychoactive impact, though the effects are often unpredictable.
6. Caffeine and Stimulants:
Stimulants like caffeine might increase anxiety or agitation during a DMT trip, but they don't usually block the experience. However, high doses of stimulants may alter the subjective nature of the trip.
7. Antihistamines:
Some antihistamines, especially those with sedating properties (e.g., Diphenhydramine, Promethazine), might dull the psychoactive effects of DMT by acting on the central nervous system.
In general, any substance that impacts serotonin pathways, alters the central nervous system, or interacts with MAO enzymes can modulate the intensity and nature of a DMT experience.
From chat GPT.
Do other substances effect or block the trip of dmt?
Yes, several substances can affect or block the effects of DMT. These include both physiological and pharmacological factors. Some substances can dampen or completely block the intensity of a DMT trip:
1. Monoamine Oxidase Inhibitors (MAOIs):
Without MAOIs: DMT is rapidly broken down in the body by the enzyme monoamine oxidase (MAO), especially when taken orally. This is why oral DMT usually has no psychoactive effect unless taken with an MAOI, like in ayahuasca brews.
With MAOIs: Substances like harmine, harmaline, and moclobemide inhibit MAO, allowing DMT to remain active in the body for a longer time. MAOIs extend and intensify the DMT experience.
2. Serotonin Receptor Blockers (5-HT2A antagonists):
DMT primarily interacts with the 5-HT2A receptor, which is crucial for its psychedelic effects. Serotonin antagonists or 5-HT2A receptor blockers can diminish or completely block the effects of DMT. Examples include:
Antipsychotic medications like Risperidone, Olanzapine, and Clozapine.
Trazodone or Mirtazapine (antidepressants that affect serotonin).
3. Selective Serotonin Reuptake Inhibitors (SSRIs):
SSRIs (e.g., Fluoxetine, Sertraline) might dull the effects of DMT due to the modulation of serotonin levels, although the effects are not as pronounced as with direct serotonin antagonists.
People on SSRIs may report diminished psychedelic effects, but not complete blockage.
4. Benzodiazepines:
Benzodiazepines (e.g., Diazepam, Alprazolam) can dull or reduce the intensity of a DMT trip. They work by calming the central nervous system and reducing anxiety, which can lead to a more muted or less immersive experience.
5. Alcohol and Other Depressants:
Alcohol and other central nervous system depressants can blunt the overall effects of DMT by inhibiting its psychoactive impact, though the effects are often unpredictable.
6. Caffeine and Stimulants:
Stimulants like caffeine might increase anxiety or agitation during a DMT trip, but they don't usually block the experience. However, high doses of stimulants may alter the subjective nature of the trip.
7. Antihistamines:
Some antihistamines, especially those with sedating properties (e.g., Diphenhydramine, Promethazine), might dull the psychoactive effects of DMT by acting on the central nervous system.
In general, any substance that impacts serotonin pathways, alters the central nervous system, or interacts with MAO enzymes can modulate the intensity and nature of a DMT experience.
flyswatter
Rising Star
- Merits
- 42
Ok thanks what about amphetamines?
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What leads you to think that amphetamines influence or specifically decrease the effects of DMT? From there on we have a more informed discussion on the subject.
- Merits
- 150
Amphetamines don't block the effects of DMT in my experience. Benzodiazepines and opiates both dull the experience though they do not switch it off or prevent it from working.. Are you hoping for something to "switch off" an unpleasant experience? DMT hits you so fast and with such intensity that it would be over before other said drug even starts working in your system. Its a psychedelic experience that is near impossible to bail out of once your in the deep end.
Your posts are super vague here.. a bit of background would be helpful as its hard to understand what your asking.. but @Phenethylamine23's response covers interactions quite well.
Your posts are super vague here.. a bit of background would be helpful as its hard to understand what your asking.. but @Phenethylamine23's response covers interactions quite well.
