Endocannabinoid death and chaos..World holds breath for factual and objective inquiry!

[hug46]

French drug trial leaves one brain dead and five critically ill

 

[obliguhl]

...the French health minister later denied this, saying it did not contain cannabis or anything derived from it.

 

[hug46]

...the French health minister later denied this, saying it did not contain cannabis or anything derived from it.

i really hope that she is right.....

 

[null24]

The vice article I read stated no cause. It remains mysterious but I'm pretty sure it was not cannabis related. A synthetic maybe?

 

[entheogenic-gnosis]

Does anybody know the chemical or iupac name of the compound which was the focus of this article?

There are many compounds that are "synthetic cb1/cb2 receptor agonists" that are quite toxic, how ever none of these synthetic cannabinoid receptor agonists occur in nature, and many of them share no relation to any natural cannabinoid.

That article failed to mention the chemical name of the compound, it only said they were investigating the endocannabinoid system.


No human has ever died from any of the cannabinoid compounds contained in the marijuana plant, no person has even suffered serious injury like becoming "brain-dead" from any of the cannabinoids found in the cannabis plant.

Keep in mind that natural cannabinoid receptor agonists occur in other places than the cannabis plant, such as Yangonin ( 4-Methoxy-6-[(E)-2-(4-methoxyphenyl)ethenyl]pyran-2-one) which is a cannabinoid receptor agonist (CB1 receptor) found in kava, and I can't speak for the safety of these compounds, but I can tell you that the compounds found in the cannabis plant do not cause injury or death.

There are also endogenous cannabinoids, which are cannabinoid receptor agonists which naturally occur in the human body
(At present, there are five recognized cannabinoids produced endogenously throughout the body: Arachidonoylethanolamine (anandamide), 2-arachidonoyl glycerol (2-AG), 2-arachidonyl glyceryl ether (noladin ether), virodhamine,[9] as well as the recently discovered N-arachidonoyl-dopamine -Wikipedia)

So when they "a study involving cannabinoid receptor agonists or "cannabinoids" that's not saying much, here a short list of cannabinoids, synthetic and natural:

Caryophyllene CBC CBCV CBD CBDV CBG CBGM CBGV CBL CBN CBV Epigallocatechin gallate Gallocatechol Perrottetinene Serinolamide A THC THC-C4 THCA THCV Yangonin, 8,11-DiOH-THC 11-COOH-THC 11-OH-THC, Arachidonoyl ethanolamide (Anandamide or AEA) 2-Arachidonoylglycerol (2-AG) 2-Arachidonyl glyceryl ether (noladin ether) N-Arachidonoyl dopamine (NADA) Oleamide RVD-Hpα Virodhamine, A-40174 A-41988 A-42574 Ajulemic acid AM-087 AM-411 AM-855 AM-905 AM-906 AM-919 AM-926 AM-938 AM-2389 AM-4030 AMG-1 AMG-3 AMG-36 AMG-41 Dexanabinol (HU-211) DMHP Dronabinol HHC HU-210 HU-243 JWH-051 JWH-133 JWH-139 JWH-161 JWH-229 JWH-359 KM-233 L-759,633 L-759,656 Levonantradol (CP 50,5561) Menabitan Nabazenil Nabidrox (Canbisol) Nabilone Nabitan Naboctate O-224 O-581 O-774 O-806 O-823 O-1057 O-1125 O-1191 O-1238 O-2048 O-2113 O-2365 O-2372 O-2373 O-2383 O-2426 O-2484 O-2545 O-2694 O-2715 O-2716 O-3223 O-3226 Parahexyl Pirnabine THC-O-acetate THC-O-phosphate Cannabicyclohexanol CP 47,497 (C6)-CP 47,497 (C9)-CP 47,497 CP 55,244 CP 55,940 HU-308 HU-320 HU-331 HU-336 HU-345 HU-910 Nonabine O-1376 O-1422 O-1601 O-1656 O-1657 O-1660 O-1871 SPA-229 Tinabinol 2-Isopropyl-5-methyl-1-(2,6-dihydroxy-4-nonylphenyl)cyclohex-1-ene
1-Butyl-3-(2-methoxybenzoyl)indole 1-Butyl-3-(4-methoxybenzoyl)indole 1-Pentyl-3-(2-methoxybenzoyl)indole AM-630 AM-679 AM-694 AM-1241 AM-2233 GW-405,833 (L-768,242) Pravadoline RCS-4 WIN 54,46 AM-1220 AM-1221 AM-1235 AM-2201 AM-2232 EAM-2201 JWH-007 JWH-015 JWH-018 JWH-019 JWH-073 JWH-081 JWH-098 JWH-116 JWH-122 JWH-149 JWH-164 JWH-182 JWH-193 JWH-198 JWH-200 JWH-210 JWH-398 JWH-424 MAM-2201 WIN 55,212-2 JWH-175 JWH-184 JWH-185 JWH-192 JWH-194 JWH-195 JWH-196 JWH-197 JWH-199 Cannabipiperidiethanone JWH-167 JWH-203 JWH-249 JWH-250 JWH-251 JWH-302 RCS-8
JWH-030 JWH-147 JWH-307 JWH-369 JWH-370, AM-883 AM-1346 ACEA ACPA Methanandamide (AM356) O-585 O-689 O-1812 O-1860 O-1861 4-HTMPIPO 5-Fluoropentyl-3-pyridinoylindole 5F-PB-22 A-796,260 A-834,735 A-836,339 A-955,840 Abnormal cannabidiol AB-001 AB-FUBINACA AB-PINACA ADB-FUBINACA ADBICA AM-1248 AM-1714 APINACA AZ-11713908 BAY 38-7271 BAY 59-3074 CB-13 CB-86 CBS-0550 GW-842,166X JWH-176 JTE 7-31 LASSBio-881 LBP-1 Leelamine MDA-7 MDA-19 NESS-040C5 NMP-7 O-889 O-1269 O-1270 O-1399 O-1602 O-2220 Org 28312 Org 28611 PF-03550096 PSB-SB-1202 QUCHIC QUPIC S-444,823 SDB-001 (2NE1) SDB-006 SER-601 STS-135 Tedalinab UR-12 (MN-25) UR-144 URB-447 VSN-16 WIN 56,098 XLR-11 Org 27569 Org 27759 Org 29647 RTI-371

...so the worst thing people can do is assume that this article is suggesting that compounds found in the cannabis plant are dangerous...

I think these articles intentionally mislead folks into thinking there's some danger in exploring cannabinoids as medicine, particularly the cannabinoids produced by the cannabis plant...

You can't patent the cannabis plant, so the pharmaceutical industry can't stand that people are healing themselves with it (and not their drugs), so they will do a good deal to provide misinformation to discredit cannabis as medicine, this may not be a case of this, but when reading about cannabis being dangerous you must always consider who it is that is telling you that cannabis is dangerous and what their true motives may be.

--------

Emerging strategies for exploiting cannabinoid receptor agonists as medicines.

Emerging strategies for exploiting cannabinoid receptor agonists as medicines - PubMed

Medicines that activate cannabinoid CB(1) and CB(2) receptor are already in the clinic. These are Cesamet (nabilone), Marinol (dronabinol; Delta(9)-tetrahydrocannabinol) and Sativex (Delta(9)-tetrahydrocannabinol with cannabidiol). The first two of these medicines can be prescribed to reduce...

www.ncbi.nlm.nih.gov

This article is an example of scientific research involving cannabinoid receptor agonists.

------

-eg

 

[Koornut]

Seems like they drank warm, salty water and called it soup.

 

[T.Harper]

the weed drug kills once again

 

[Chan]

Contrary to earlier reports, the health minister Marisol Touraine stressed that the drug did not contain cannabis or any element derived from cannabis. The minister said the drug was meant to act on the body’s endocannabinoid system. It had an impact on receptors which regulate pain, mood or appetite.

French drug trial leaves one brain dead and three facing permanent damage

Government promises to investigate ‘unprecedented’ accident as six volunteers remain in hospital after trial for pharmaceutical company Bial

www.theguardian.com

Emphasis added.

 

[Jin]

the herb is pure

 

[Nathanial.Dread]

Does anybody know the chemical or iupac name of the compound which was the focus of this article?
...
-eg

It's BIA 10-2474, an experimental Fatty Acid Amide Hydrolase (FAAH) inhibitor. I've been following this pretty closely, and I'm intrigued by these deaths: other FAAH inhibitors have been generally very well tolerated. It's possible that BIA has activity in some other system that was completely unexpected, or we're about to learn some really interesting stuff about the endocannabinoid system. The injured parties weren't the only one's who received the drug, there are apparently other test subjects who are presumably doing well, so perhaps these unlucky people got the results of a botched synthesis (remember the whole MPPP/MPTP thing?), or as I said before, we're about to learn some really fun new stuff.

IUPAC: 4-[3-(carbamoylamino)phenyl]-N-cyclopentyl-N-methylimidazole-1-carboxamide.

It also has a wiki page, although it doesn't say much:

BIA 10-2474 - Wikipedia

en.wikipedia.org

Blessings
~ND

 

[obliguhl]

i really hope that she is right.....

The problem is, to have this in your thread title despite not knowing wether or not it is actually true. It gives cannabis a bad name even thought it might not be warranted.

Has it been established that the drugs were the cause? People drop dead all the time.

 

[hug46]

The problem is, to have this in your thread title despite not knowing wether or not it is actually true. It gives cannabis a bad name even thought it might not be warranted.

My thread title was shamefully and sensationally perjorative, i sort of did that on purpose . I really didnt know what to make of the reports (all of which initially claimed that the drug was cannabis based) as i have never heard of anyone becoming brain dead from cannabis. But i dont think that my posting a title like that here would give cannabis a bad name as most members are likely to take an intelligent and objective view in relation to the pros and cons of drug taking and give the appropriate feedback.

Has it been established that the drugs were the cause? People drop dead all the time

90 people in the trial, 5 subsequently in hospital and 1 dead. If it wasn"t the drug, its a helluva co-incidence.

 

[Ufostrahlen]

The problem is, to have this in your thread title despite not knowing wether or not it is actually true. It gives cannabis a bad name even thought it might not be warranted.

this!

Even green tea interacts with the endocannabinoid system, so the whole cannabis-based blah blah is garbage. :thumb_dow BIA 10-2474 doesn't even look like a conventional cannabinoid, it lacks the fatty acid sidechain.

the weed drug kills once again

We all can be lucky that they weren't able to rape someone, like it happens with conventional weed.

My thread title was shamefully and sensationally perjorative, i sort of did that on purpose .

You can change it anytime - if you want.

 

[hug46]

My thread title was shamefully and sensationally perjorative, i sort of did that on purpose .

You can change it anytime - if you want.

I snuck a quick look at your initial unedited post before dinner and you said that my title was shit (but you loved me anyway).
Based upon these strong emotional responses from you i feel that my title has the artistic merit that i intended it to have and am therefore loath to change it.

But for you i will.

 

[Ufostrahlen]

My thread title was shamefully and sensationally perjorative, i sort of did that on purpose .

You can change it anytime - if you want.

I snuck a quick look at your initial unedited post before dinner and you said that my title was shit (but you loved me anyway).
Based upon these strong emotional responses from you i feel that my title has the artistic merit that i intended it to have and am therefore loath to change it.

But for you i will.

Haha, I'm so glad the editing function exists. I thought "what a load of dog shit" when I read it in the newspaper and then I was shocked that a fellow Nexian perpetuates that sensational garbage. But I know that we all like a trolling once in a while, I'm no exception. The new title is much better and even accurate to the media intention.

 

[Orion]

Hahahah!

Hug, whilst I agree with the qualms about the title mentioned previously, your good humour has dampened them for me :lol: Indeed the new title, whilst even more sensational sounding, is technically more accurate.

 

[hug46]

Thankyou for your comments guys.I am glad that we could come to a mutually acceptable solution.

Haha, I'm so glad the editing function exists.

I thought that your pre-edited comment was blunt but tempered with kindness and i respect that.

 

[Ufostrahlen]

I thought that your pre-edited comment was blunt but tempered with kindness and i respect that.

Thanks.

 

[downwardsfromzero]

Inhibiting FAAH seems like a daft idea to me, but then who am I to say?

 

[Nathanial.Dread]

Inhibiting FAAH seems like a daft idea to me, but then who am I to say?

Really? I have to say, I think it's brilliant, and the other ones that have been tested have been pretty safe and effective. Why this one seems to have been so damaging to these poor people (but not anyone else in the trial) is the headscratcher.

Blessings
~ND