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EXTRACTION GUIDE: Principles of Alkaloid Extraction (in relation to N,N-Dimethyltryptamine)

Migrated topic.
Bodhisativa said:
some one said:
EDIT: I did the titration. I used 500ml of my stock solution HCl, and titrated against my stock solution of NaOH. HCl is 0.001M and NaOH is 5M.

Within 3mL of NaOH, the equivalence point was reached. At 5mL, the pH was 11. At 10mL the pH plateaud at 12, but I'm using a crappy pool pH meter. The guide has bee edited.
Click to expand...
Converting your titration experiment concentrations to grams:
HCL = 0.001 mole/liter * 0.5 l = 0.0005 mole = 0.0005 mole * 36.46 g/mole = 0.02 gram
NaOH = 5 mole/liter * 0.003 l = 0.015 mole = 0.015 mole * 39.9 g/mole = 0.60 gram

That's my point...

In a 500 ml solution, it takes 0.02 gram of HCL to reach pH 3. Adding 0.60 gram of NaOH to that solution raises the pH to 12 (you say).
Which makes sens as all it takes is 0.40 gram of NaOH to reach a pH 12 in 1000 ml of water (0.01 M) - according to the link you posted

Again, if that's so and 0.40 g of lye reaches pH 12 which is sufficient to extract, why are all teks using 50-100g of lye (factor 100-200 more)?
Click to expand...

For my HCl stock solution, I pipette 1mL of 320g/L HCl into 10L of distilled water. That's brings the pH between 3-4.

As to why most teks use huge amounts of lye, I honestly don't know. Maybe because a lot of teks are based on other teks. My guide is heavily inspired from MAX ION and Earthwalkers. So I just used similar quantities.


I'll do another extraction using absolute minimal quantities of everything and I'll post my results.
Click to expand...

Could the amounts of acid and lye have something to do with the buffer capacity of the root bark. Most plants have a certain buffer capacity so to counteract this buffering effect you need more acid/base than a theorethical pH calculation in water.

I don't have a pH meter at home so I'm not sure about the buffer capacities of root bark.
 
Thistle Elf said:
Bodhisativa said:
some one said:
EDIT: I did the titration. I used 500ml of my stock solution HCl, and titrated against my stock solution of NaOH. HCl is 0.001M and NaOH is 5M.

Within 3mL of NaOH, the equivalence point was reached. At 5mL, the pH was 11. At 10mL the pH plateaud at 12, but I'm using a crappy pool pH meter. The guide has bee edited.
Click to expand...
Converting your titration experiment concentrations to grams:
HCL = 0.001 mole/liter * 0.5 l = 0.0005 mole = 0.0005 mole * 36.46 g/mole = 0.02 gram
NaOH = 5 mole/liter * 0.003 l = 0.015 mole = 0.015 mole * 39.9 g/mole = 0.60 gram

That's my point...

In a 500 ml solution, it takes 0.02 gram of HCL to reach pH 3. Adding 0.60 gram of NaOH to that solution raises the pH to 12 (you say).
Which makes sens as all it takes is 0.40 gram of NaOH to reach a pH 12 in 1000 ml of water (0.01 M) - according to the link you posted

Again, if that's so and 0.40 g of lye reaches pH 12 which is sufficient to extract, why are all teks using 50-100g of lye (factor 100-200 more)?
Click to expand...

For my HCl stock solution, I pipette 1mL of 320g/L HCl into 10L of distilled water. That's brings the pH between 3-4.

As to why most teks use huge amounts of lye, I honestly don't know. Maybe because a lot of teks are based on other teks. My guide is heavily inspired from MAX ION and Earthwalkers. So I just used similar quantities.


I'll do another extraction using absolute minimal quantities of everything and I'll post my results.
Click to expand...

Could the amounts of acid and lye have something to do with the buffer capacity of the root bark. Most plants have a certain buffer capacity so to counteract this buffering effect you need more acid/base than a theorethical pH calculation in water.

I don't have a pH meter at home so I'm not sure about the buffer capacities of root bark.
Click to expand...

The pH of the acid and the root bark did not deviate from the pH of the stock solution of acid. If there is a buffering effect, it seems it is negligible. I have not tested this thoroughly, though.

I'll make sure to investigate this when I do my next extract. Thanks!
 
I read through q21q21’s a/b tek until I understood it and can discuss the process from memory.
However, for educational purposes I was trying to determine if the locally available mineral spirit solvents were non polar & came up short. Still looking to learn though.
 
ogcricket said:
I read through q21q21’s a/b tek until I understood it and can discuss the process from memory.
Click to expand...
That's a good start, especially if you can relate it to the chemical principles underlying why each step is carried out.
ogcricket said:
However, for educational purposes I was trying to determine if the locally available mineral spirit solvents were non polar & came up short. Still looking to learn though.
Click to expand...
Here's a thread better suited to this question:

The official "Is this chem ok to use? / Where can I find ...?" thread

It is a common question that people ask, if a certain chemical is OK to use for extraction or not, and also where to find such and such chemical. Instead of cluttering up the forum with hundreds of threads about it, those who have these question can post here (and threads made with such...
forum.dmt-nexus.me forum.dmt-nexus.me
 
sTumbas said:
The images on this amazing page won’t download!
Click to expand...
Unfortunately, this is a third-party hosting issue and cannot be resolved without obtaining the original images. Since this is very unlikely to happen, I would advise downloading the pdf instead.

There is a possibility that the images could be recovered from the pdf. If someone were to do that and re-upload them, I would happily move them into their correct places in the original posts.
 
bezevo said:
ummmm.... i can't seem to find the PDF ?
Thanks

bez
Click to expand...
On the first page of the thread?

EXTRACTION GUIDE: Principles of Alkaloid Extraction (in relation to N,N-Dimethyltryptamine)

This is a comprehensive guide on extracting DMT. This is not really a tek, it's more of a methodology. This guide goes through basic chemistry and how it relates to DMT extractions with respect to people with zero chemistry knowledge. It is pretty thorough, going through basic calculations and...
forum.dmt-nexus.me forum.dmt-nexus.me
 
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