High doese of rue feel very toxic and are never any fun.  In fact, none of the harmala's are any fun at high doses.  With Caapi at least you can get some very important visions (not visuals), but it is still an uncomfortable ride.

The type of extraction you did also makes a big difference.  If you only did an A/B you will have all the toxic alkaloids that are in the rue.  If you did a Manske at some point a large majority (if not all) should have been removed.  IF you only did the A/B 400mgs would produce a very unhappy experiences.

Mixing a high dose of harmine/harmaline (that's what's in rue) with a bit of coffee makes for a VERY unpleasant ride.  If people decide to take large doses of harmala alkaloids they should refrain from coffee, stims of any kind (esp "energy drinks") and for the most part, all pharma's.

Even RIMA's mixed with the wrong thing can be a disaster.