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Health concerns dmt. High blood pressure, high cholesterol, elevated liver enzymes. Medications

imjusthere123

Esteemed member
I've taken psychedelics many many times, mainly shrooms. As I've gotten older I've started to actually care about my health and consequences. I was planning on doing a deem trip soon, I've done it before while on adderall. Currently I have a little higher than normal blood pressure, high cholesterol and elevated liver enzymes. I've done some research and have came to the conclusion that I should lay off the adderall before tripping. That being said I take lamotrigine and quetiapine. The health issues are to be determined and the doctors don't seem to care as much because of my relatively young age. I did notice that last couple times I did mushrooms I get really clammy and cold, or the opposite overheating and sweating. This passes after the initial come up of the trip. If anyone could shed some light on this would be very helpful. Thanks in advance.
 
I feel like this question has too many pharmacological, environmental, and emotional coinciding variables. There is a lot to it. Put simply:

It is my hunch that if you get off of lamotrigine and quetiapine (needs to be progressive!), that your entire body will have more flexibility with which you accommodate the psilocybin you are introducing to your body. I don’t think the adderall really has that much of an influence on the reactions you described.

These two meds really make your body more stiff, so I’m not surprised that when you are coming up on these serotonergic psychedelics, that you might not be adapting thermally as well. Capacity for thermal adaptation is a very very deep thing. These meds basically just stop everything, everywhere. Please don’t take them for more than a decade or two!!🐵 You should especially not be on a dopaminergic blocking agent for any extended period of time. I'm a very antiantipsychotics person F Y I .

Best wishes luv
 
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I've taken psychedelics many many times, mainly shrooms. As I've gotten older I've started to actually care about my health and consequences. I was planning on doing a deem trip soon, I've done it before while on adderall. Currently I have a little higher than normal blood pressure, high cholesterol and elevated liver enzymes. I've done some research and have came to the conclusion that I should lay off the adderall before tripping. That being said I take lamotrigine and quetiapine. The health issues are to be determined and the doctors don't seem to care as much because of my relatively young age. I did notice that last couple times I did mushrooms I get really clammy and cold, or the opposite overheating and sweating. This passes after the initial come up of the trip. If anyone could shed some light on this would be very helpful. Thanks in advance.
I would not worry too much about an slightly higher blood pressure, or high cholesterol when you are still young, just get back for a blood test in a year or so and see where you’re at. Your doctor will then be able to advise you if you need to take care of that. Onto your medicines, these are very likely to influence the outcome of any psychedelic. I recommend that you talk to your doctor and discuss your plans to take an psychedelic and if that is an option at this point in time.

I feel like this question has too many pharmacological, environmental, and emotional coinciding variables. There is a lot to it. Put simply:

It is my hunch that if you get off of lamotrigine and quetiapine (needs to be progressive!), that your entire body will have more flexibility with which you accommodate the psilocybin you are introducing to your body. I don’t think the adderall really has that much of an influence on the reactions you described.

These two meds really make your body more stiff, so I’m not surprised that when you are coming up on these serotonergic psychedelics, that you might not be adapting thermally as well. Capacity for thermal adaptation is a very very deep thing. These meds basically just stop everything, everywhere. Please don’t take them for more than a decade or two!!🐵 You should especially not be on a dopaminergic blocking agent for any extended period of time. I'm a very antiantipsychotics person F Y I .

Best wishes luv
Let’s be careful, a moodstabilizer and an antipsychotic are usually prescribed for good reason.
 
I would not worry too much about an slightly higher blood pressure, or high cholesterol when you are still young, just get back for a blood test in a year or so and see where you’re at. Your doctor will then be able to advise you if you need to take care of that. Onto your medicines, these are very likely to influence the outcome of any psychedelic. I recommend that you talk to your doctor and discuss your plans to take an psychedelic and if that is an option at this point in time.


Let’s be careful, a moodstabilizer and an antipsychotic are usually prescribed for good reason.
I'm not exactly on a high dose of either meds. The way it feels when I come up is just worrisome, rapid heart rate, feeling like poor circulation. Maybe it's mainly in my head because I'm aware of the health issues I have idk. Im really not worried about the medication thing I was more inquiring about interactions between dmt and anti psychotic. Kinda like how ssri's can cause serotonin syndrome.
 
I feel like this question has too many pharmacological, environmental, and emotional coinciding variables. There is a lot to it. Put simply:

It is my hunch that if you get off of lamotrigine and quetiapine (needs to be progressive!), that your entire body will have more flexibility with which you accommodate the psilocybin you are introducing to your body. I don’t think the adderall really has that much of an influence on the reactions you described.

These two meds really make your body more stiff, so I’m not surprised that when you are coming up on these serotonergic psychedelics, that you might not be adapting thermally as well. Capacity for thermal adaptation is a very very deep thing. These meds basically just stop everything, everywhere. Please don’t take them for more than a decade or two!!🐵 You should especially not be on a dopaminergic blocking agent for any extended period of time. I'm a very antiantipsychotics person F Y I .

Best wishes luv
Plzz see my comment to varallo
 
I'm not exactly on a high dose of either meds. The way it feels when I come up is just worrisome, rapid heart rate, feeling like poor circulation. Maybe it's mainly in my head because I'm aware of the health issues I have idk. Im really not worried about the medication thing I was more inquiring about interactions between dmt and anti psychotic. Kinda like how ssri's can cause serotonin syndrome.
I guess my biggest worry is a possible cardiac episode more or less. The chances of that actually happening are probably slimmer than im making it out to be. Im a little bit of a hypochondriac. Lol
 
I guess my biggest worry is a possible cardiac episode more or less. The chances of that actually happening are probably slimmer than im making it out to be. Im a little bit of a hypochondriac. Lol
1)
Well the thing is that these molecules interact with all organs in your body via the bloodstream, the nervous system, and indirectly through the stimulus of other organs. An antipsychotic is never only involved with your cerebral organ, but all the rest. Where you try to engage one thing, you unintentionally influence countless more. (This is one of many reasons why I don't really like antipsychotics.)

2)
If you have a nice psychiatrist, I think it would be worth asking them, as the question of the heart is both complicated and important. It involves many interacting organs/systems and some detailed anatomical knowledge. A good answer is worth investing in. Even $300 out of pocket (with informed and concisely prepared notes for an efficient conversation) for an hour appointment with a specialist I'd consider worthwhile.

3)
Do you have a watch with an EEG? I think that is be a great way to get a realtime visual reading of your QT interval, and the watch will also 'get to know' your QT interval/heart habits across time so it'll have a good baseline of data to judge by. A thermometer might also be nice to see what your body temp is as it can be surprising at times.

re:
As for serotonin syndrome, from what I can gather, it's generally difficult to trigger without a MAOI in the mix. Usually it would be a mix of drugs that cause it: Primarily MAOI, with a strong SSRI, or I think maybe a MAOI with a regular SSRI, and a Serotonergically mimicking drug itself could also be lethal/damaging, but without MAOI, generally, it's way less likely, and all your RX'd largely avoid SSRI-like behaviors if not completely. Mushrooms do (I think) have a very very slight MAOI action but I'd wager it's extremely negligible.
but
I don't know that much about how the rapid onset of DMT would affect you. It's complicated because without MAOI and SSRI's present, the only way the DMT could be lethally contraindicated with your meds, would be via a more indirect and wholistic interaction, which I am unable to assess. It's true that some of your symptoms are shared by serotonin syndrome, but serotonin syndrome is only bad because of the lethal physical reactions it can cause. There are many roads to these lethal reactions outside of serotonin syndrome. DMT could perhaps be dangerous not in a serotonin syndrome way, but a serotonin SHOCK type of way, which would be a bit different from serotonin syndrome. With antipsychotics, the body's response to shocking types of events can be altered which is what concerns me about smoked DMT. but idk these are just ramblings and idk idk idk

Also I don't think addreall is really in the picture.


// *sips quadruple espresso
You might also want to consider testing slightly different thermal conditions. If thermal balance helps you out, it might not be serotonin syndrome, but just you body struggling to balance thermally (which is a struggle that can produce many of the effects you mentioned). The psilocybin will relax you, which will lower your blood pressure and body temperature. Your drugs there will also relax you via various means. An example of how things might interact with each other:
As you get colder, your body might try to heat up using adrenaline, but the adrenaline could be partially (even if only indirectly), blocked by antipsychotics, causing your body to release more adrenaline to achieve the same effect. Now you are sweating due to excessive adrenaline which is ineffectively raising your body temperature ~ due to the blockades by the antipsychotics or whatever. This excess adrenaline now revs up your heart. Your body tries to constricts to heat up but it can't. This is just one random hypothetical chain of events.
So get a warm blanket and put it over yourself for 10 or 15 minutes. See if raising your body temperature lessens your adrenaline response by fixing the body temperature issue (caused by the fact that psilocybin and the antipsychotics both act to chill you out).

*sips more coffee*
I never drink coffee

Body temperature, sweating, vasodilation/constriction, heart rate, metabolism, PNS and SNS activation, etc all ~ literally everything ~ is interconnected and in one movement. Your concern about the heart rate, the stability of the hearts function, the clammy cool sweats, adrenaline anxiety, etc all of that requires a complex analysis. I really don't know and can't help you come to any knowledgeable, reliable, dependable conclusions like a professional psychiatrist (or internal med doc) would.
Thermo-dysregulation goes DEEP, since thermoregulatory reflexes of the body are one of the THE most central survival mechanisms.
Serotonin syndrome also is quite deep. Both phenomena are very complex and wide reaching.
My brain can't really function today anymore xD

Those drugs in your system could literally, be giving your body mixed signals about what is thermally happening. causing certain parts to modulate blood pressure inappropriately, which the body might tries to rectify with adrenaline, or something. idk it's just complex xD They can effect the contractile capacity of your muscles themselves. Dopamine blockade can for instance, extend your QT interval. Crazy stuff. I would have to double check whether that applies to your dopamine blocking medication however. But these are all significant in the analysis.

cardiac issue is tied to everything

I'm not a doctor AT ALL luv,

What the heck am I even saying anymore. I can't focus on caffeine 😝

please forgive me!
I'm trying to keep these things short but I don't understand such complex systems and am not smart enough to say something as simple as E=mc^2. All things considered, my original response still stands in answer to everything in this thread.
💕😂
 
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Well the thing is that these molecules interact with all organs in your body via the bloodstream, the nervous system, and indirectly through the stimulus of other organs. An antipsychotic is never only involved with your cerebral organ, but all the rest.

If you have a nice psychiatrist, I think it would be worth asking them, as the question of the heart is both complicated and important. It involves many interacting organs/systems and some detailed anatomical knowledge.

Do you have a watch with an EEG? I think that is be a great way to get a realtime visual reading of your QT interval, and the watch will also 'get to know' your QT interval/heart habits across time so it'll have a good baseline of data to judge by.

As for serotonin syndrome, from what I can gather, it's generally difficult to trigger without a MAOI in the mix. Usually it would be a mix of drugs that cause it: MAOI, with a strong SSRI, or I think maybe a MAOI with a regular SSRI, and a Serotonergically mimicking drug itself, but without MAOI it's way less likely, and all your drugs largely avoid Serotonin if not completely so the SSRI function is also very minimal as is for you if you were for instance, to take Mushrooms.
but
I don't know that much about how the rapid onset of DMT would affect you. It's complicated because without MAOI and SSRI's present, the only way the DMT could be lethally contraindicated with your meds would be via a more indirect, wholistic interaction which I am unable to assess. It's true that some of your symptoms are shared by serotonin syndrome.


// *sips quadruple espresso
You might also want to consider testing slightly different thermal conditions. If thermal balance helps you out, it might not be serotonin syndrome. The psilocybin will relax you, which will lower your blood pressure and thus, body temperature.
As you get colder, your body might try to heat up using adrenaline, but the adrenaline could be partially (even if only indirectly), blocked by antipsychotics, causing your body to release more adrenaline to achieve the same effect. Now you are sweating due to excessive adrenaline which is ineffectively raising your body temperature ~ due to the blockades by the antipsychotics or whatever. This excess adrenaline now revs up your heart. Your body tries to constricts to heat up but it can't. This is just one random hypothetical chain of events in my brain.
So Fire says, hey! get a warm blanket and put it over yourself for 10 or 15 minutes. See if raising your body temperature lessens your adrenaline response, because it fixes the doubly low body temperature issue caused by the fact that psilocybin and the antipsychotics both act to chill you out.

*sips more coffee*

Body temperature, sweating, vasodilation/constriction, heart rate, metabolism, PNS and SNS activation, etc all ~ literally everything ~ is interconnected and in one movement. Your concern about the heart rate, the stability of the hearts function, the clammy cool sweats, adrenaline anxiety, etc all of that requires a complex analysis. I really don't know and can't help you come to any knowledgeable, reliable, dependable conclusions like a professional psychiatrist (or internal med doc) would.
Thermo-dysregulation goes DEEP, since thermoregulatory reflexes of the body are one of the THE most central survival mechanisms.
Serotonin syndrome also is quite deep. Both phenomena are very complex and wide reaching.
My brain can't really function today anymore xD

Those drugs in your system could literally, be giving your body mixed signals about what is thermally happening. causing certain parts to modulate blood pressure inappropriately, which the body might tries to rectify with adrenaline, or something. idk it's just complex xD They can effect the contractile capacity of your muscles themselves. Dopamine blockade can for instance, extend your QT interval. Crazy stuff. I would have to double check whether that applies to your dopamine blocking medication however. But these are all significant in the analysis.

cardiac is another word for "everything"

What the heck am I even saying anymore. I can't focus on caffeine 😝

Sry please forgive me!
💕😂
Honestly the way you explain things is very similar to the way i do just with better grammar😂 yes i did fully understand that and it was very well stated! I don't think the antipsychotics are causing the sweating and unsettling start to the tip, years past I've been on them and had no issues other than pre trip jitters. This is what my reasoning is for blood flow restriction being the possible cause. I do have a smart watch and have left it in my beside table for months. If anything you have successfully convinced me to wear my watch again and monitor that😂
The biggest thing I probably don't want to accept is that its my liver not processing things properly due to elevated enzymes, which could be the soul reason to why I have high cholesterol or vise versa. I have made many life changes in the past couple months. I quit vaping which I was on since I was 13 or 14 basically, im eating a clean low fat, low sugar, low cholesterol diet. I am buying a blood pressure machine soon here, going back for a checkup with my doctor to see if I cam pressure him into taking this seriously(doesnt help lower my cholesterol if I'm stressed about lowering my cholesterol)
I think I'm worried about having a possible stroke or my heart stops something wild like that, I have allways been able to ride that out but maybe with the knowledge of where I am health wise trips me out. It also is most likely just confirmation from the Devine that I do need to keep myself healthy and continue my path on taking care of myself.
I don't see a psychiatrist or anything like that, I debated paying privately for a naturopath. Just so I could get a more wholeistic opinion and not have drugs peddled onto me like doctors like to do. I feel like if I'm gunna bring up psychedelics to any doctor, this one would be the most understanding besides a psychotherapist that actively treats conditions with psychedelics. Gosh I just woke up and yes I need that quadruple expresso now😂😂😂 thank you very much for your response I most likely needed someone's opinion or thoughts on the matter opposed to my conscious spiraling into every possible variable reason or situation that could happen. Subconsciously needed a fellow traveler to ease my nerves on the matter. I hope this is understandable I should really take an English class😅😅
 
No drugs
Healthy food
Sleep & Exercise
Is my quantum answer to everything
🐒

Getting off of nicotine will directly help your liver, and directly help your cholestrol, but could take months to years to see full recovery of the liver.
Your other meds do still stress your liver though
It seems like healthy eating habits can really help cholesterol and your liver (over several months)
Exercise and good Sleep are amazing for everything, always
Idk about genetic predispositions...

❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️
 
No drugs
Healthy food
Sleep & Exercise
Is my quantum answer to everything
🐒

Getting off of nicotine will directly help your liver, and directly help your cholestrol, but could take months to years to see full recovery of the liver.
Your other meds do still stress your liver though
It seems like healthy eating habits can really help cholesterol and your liver (over several months)
Exercise and good Sleep are amazing for everything, always
Idk about genetic predispositions...

❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️
Yes I'm in another stage of life, learning how to be better. Im talking to my doctor about my meds when I see him this week about it being a contributing factor. I don't think I need to be on them anymore, im on one of the lowest dosages you can be on. Was just to take the edge off a couple years back so I could find stability. Could've almost been a placebo effect. Im very contious of my subconscious actions if that makes sense or is explained right. When I was on mushrooms last after the agonizing paranoia of dieing stopped which was about 30 mins and I reached the bliss state of euphoria and wisdom it really hit me that I'm doing the right thing and how important it is. Also that if I wanted to spend time in the Devine realm which is one of my true loves in life I have to keep up my end of the bargon. Im not fully off nicotine yet I'm getting closer to being fully off. I use the pouches which still isn't great but it has alot less effects than killing the blood vessels in your lungs. I was on 15, recently went down to 6 and the next step is 4. It's a good thing I'm stubborn cuz I never really set out to quit this stuff it just randomly dawned on me and I just stopped. I hate not being able to do it but I havnt caved which is surprising cuz I usually do. I just have some sort of drive that came out of no where. My guides or the beings that overwatch me give me harsh lessons sometimes because I am stubborn and usually learn the hard way, although it's all out of love. My next thing which I should integrate now is learning before it happens, even though I overthink every possible scenario I lack on the simple things for example my health things that recently arose. I want to explore the quantum boundaries respectfully, learn and teach as much as I can. I feel as if I have a purpose to figure something out between spirituality/the science behind it all and find a link that has not yet been found or proven. Although this may be delusion it keeps me going. Was very very reassuring chatting about this. I value your time and effort spent to help give me a different perspective and support.
 
are we both on stimulants?? 😂

Something of interest for me, which you might like!, is the spiritual study of Natural Law. The belief that there are truths, and that we are on a learning path to literally embody and be those truths, ever close and closer through the School of Life (on earth). The more our actions are aligned with natural law, the more healthy everything is in every way. EVERYTHING. Natural law is like physical law (quantum physics) integrated with spiritual law, to produce the spirit-mind-body laws we call Natural Law ☀️ of which divine beings are ever clearer and closer expressions of.

Getting off of nicotine is amazing 🔥😄
 
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I havnt had any yet today oh you should see when I have🤣🤣🤣
So I've never looked into this or heard of this really, I definitely should though it sounds right up my ally! I feel like I almost have this mindset already.. We should direct message and I'll share with you a breakthrough experience that I think you would find quite interesting.
 
are we both on stimulants?? 😂

Something of interest for me, which you might like!, is the spiritual study of Natural Law. The belief that there are truths, and that we are on a learning path to literally embody and be those truths, ever close and closer through the School of Life (on earth). The more our actions are aligned with natural law, the more healthy everything is in every way. EVERYTHING. Natural law is like physical law (quantum physics) integrated with spiritual law, to produce the spirit-mind-body laws we call Natural Law ☀️ of which divine beings are ever clearer and close expressions of.

Getting off of nicotine is amazing 🔥😄 it annihilates peripheral healing/restoration capacity.
Do you know of any audio books that cover this?
 
Spirit Mind Emotion Body(physicality) are all connected... we are learning always not only on the physical plane, but on all planes. A lesson on the physical plane is a lesson on all other planes and vice versa. If you are kind, so too will your physical mental and spiritual realities change. How we are doing, is what we see and notice. What we notice then changes how we react and do, and what we see next. We are learning and manifesting on all fronts with each moment the school of life gives us. I don't know any books whatsoever that cover this... but some of this content, and your own spiritual experience are probably good places to start... idk xD While not overtly stated, I think many spiritual traditions do try and reflect the collective wisdom humanity has accumulated about such matters. Laws of spiritual flowering (aka, 'unfolding' or 'evolution' but I like to call it flowering 😉). In the west we have esoteric mystical societies that do a good rational job of talking about some of these things, but ultimately, spiritual law is learned through physical, mental, and spiritual challenges all (which are all the same but you know what I'm saying. Speech itself is artistic :))
so on and so forth
yada ya
yada yee!
 
Spirit Mind Emotion Body(physicality) are all connected... we are learning always not only on the physical plane, but on all planes. A lesson on the physical plane is a lesson on all other planes and vice versa. If you are kind, so too will your physical mental and spiritual realities change. How we are doing, is what we see and notice. What we notice then changes how we react and do, and what we see next. We are learning and manifesting on all fronts with each moment the school of life gives us. I don't know any books whatsoever that cover this... but some of this content, and your own spiritual experience are probably good places to start... idk xD While not overtly stated, I think many spiritual traditions do try and reflect the collective wisdom humanity has accumulated about such matters. Laws of spiritual flowering (aka, 'unfolding' or 'evolution' but I like to call it flowering 😉). In the west we have esoteric mystical societies that do a good rational job of talking about some of these things, but ultimately, spiritual law is learned through physical, mental, and spiritual challenges all (which are all the same but you know what I'm saying. Speech itself is artistic :))
so on and so forth
yada ya
yada yee!
Trying to figure out the chat I'm very new to this forum. I very much agree with you that its a personal journey rather than something that could be fully explained as everyone is thier own individual being with different purposes, mindsets, intentions etc..
 
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