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Hippophae - sea-buckthorns

Migrated topic.
dithyramb said:
Yes, chopping up wood would pose a challenge that needs a creative solution.

I would like to reiterate my question about the anti-psychedelic component, as I believe it to be very crucial. Have we identified what it is?
Click to expand...
To the question, I'd say "no, but…" since:
  • We know there are β-carbolines present
  • Some β-carbolines have a measurable action at benzodiazepine receptors
  • There should be a link to a paper around here somewhere that references this benzodiazepine-like activity directly in relation to elaeagnaceous plants.
We may have enough puzzle pieces here to get a reasonable idea of the picture.
 
Here are a couple of the tiny number of papers that I could find covering analysis of sea buckthorn bark.
pubmed.ncbi.nlm.nih.gov

Protective Effect of Two Alkaloids from Hippophae rhamnoides Linn. against Doxorubicin-Induced Toxicity in H9c2 Cardiomyoblasts - PubMed

These results suggest that alk-A and alk-B can inhibit Dox-induced apoptosis in H9C2 cardiac muscle cells via inhibition of cell apoptosis and improvement of mitochondrial function, while alk-B showed more protection. Alk-B could be a potential candidate agent for protecting against...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
This last one covers a β-carboline called hippophamide, which has a three carbon cyclic amide substituent spanning the 1- and 2-positions to form an additional five-membered ring. First reported here:

And an old one (1961)
link.springer.com

A 5-hydroxytryptamine from Hippophae rhamnoides as an antitumor preparation in experiments on animals - Bulletin of Experimental Biology and Medicine

5-hydroxytryptamine was recently isolated from the bark ofHippophae rhamnoides by G. P. Men'shikov and M. F. Petrova. The results of investigation of the action of the hydrochloride of the alkaloid upon the organism and tumors of mice and rats are presented. The preparation was named hippophain...
link.springer.com link.springer.com
"5-hydroxytryptamine" there may, just possibly, be referring to a 5-hydroxytryptamine derivative, which would include hippophamide.

What do we know about the psychoactive properties, if any, of hippophamide? Absolutely nothing, it would seem!

It appears the binomial Elaeagnus rhamnoides also has current usage, so the search may need expanding a little. [Edit: I've just checked and nmthing comes up.]

Phytochemistry and pharmacology of sea buckthorn (Elaeagnus rhamnoides; syn. Hippophae rhamnoides): progress from 2010 to 2021 - PMC

Sea buckthorn (Elaeagnus rhamnoides; syn. Hippophae rhamnoides) is a thorny shrub or a small tree belonging to the Elaeagnaceae family, native to Eurasia. Sea buckthorn fruit is rich in vitamins and minerals, oils from the seeds and fruit flesh find ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
 
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