I have had one experience that stands out above the rest in terms of what I would call a "break through". My method of smoking was, and remains, to sandwich the spice between white sage or a Native American herbal smoking blend (non psychoactive). The first hit usually just gets the cherry going, though I may have some slight body buzzing/auditory buzzing. At this point, the bowl is good to go. Most of the time, I take two very large hits, held for a considerable period of time, and meditate and simply enter into the experience (which is different with each run). To break through, for me, I get to the peak of my 2nd hit, and when the thought of taking another hit is completely unimaginable (and it was, my friend had to strongly urge me to push through), I have to force another hit. I've done this once as it was a difficult experience to deal with and recover from (though beautiful and valuable) -- everything in front of me dissolved into fractals, I closed my eyes, and I was out.
I did lose all awareness of a body. For a time, I didn't remember having a body -- I know this, because when coming back, I remembered that I have a body. I entered into a golden radiant light and every last bit of what I would identify as "me" simply dissolved into this light. I was not divided from it, I was it, it was me, and "we" were one collective experience. It was really a kind of ridiculously powerful, heavenly realm where all beings and presences existed at such a high frequency that they couldn't take individual form.
And then I was sent into a realm of extreme darkness wherein I encountered the most fearsome, loathsome entities imaginable -- of reptilian, serpent-like quality, who embraced me in a cold, un-breathing, life-sucking kind of way. It was honestly terrifying. And yet worth it all the same.
I do believe that there is a point at which everyone can fully "leave", but the details will be different and personal. Most of the time, I arrive at the "gate", so to speak, and these beings, who present themselves through the fractals and patterning, try to welcome me in (encouraging me to take in a dose sufficient to fully enter). Most of the time, it simply suffices to get to a good sub-breakthrough dose and show my recognition to the spirits and beings as they present themselves to me through the leaves, the trees, the clouds, the grass, everything. The more recognition I give them and the more I allow myself to simply be taken away by them, the more vivid my experience with them becomes. Sometimes, I'll utter a word or two "I recognize you, show yourselves to me." This is sufficient to make contact with that realm and gain insights while viewing it. It's certainly not always necessary, or even desirable, to completely dissolve into it.
Just my two cents.
-Chris