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How to remove NMT from extractions
- Thread starter Dr_Sister
- Start date
nn-DMT said:
I will look for other publications regarding it later but you can check Burnt's analysis for example:
nn-DMT said:
It shouldn't be too difficult to calculate the NMT content of MHRB using the proceedure posted at the top of this thread . . .
d*l*b
Esteemed member
When playing with A. Confusa earlier this year I was plagued by the fact that an oily substance (NMT?) was being picked up with my naphtha pulls. I think it maybe possible to separate to some degree by the fact that it seems to drop out of naphtha at room temperature before much of the spice does.
A fair amount can be removed by working with an excess of naphtha, letting the oily stuff drop out, decanting solvent and then evapping until at a level where the product can be freeze precipated.
Anyone else noticed this behaviour?
A fair amount can be removed by working with an excess of naphtha, letting the oily stuff drop out, decanting solvent and then evapping until at a level where the product can be freeze precipated.
Anyone else noticed this behaviour?
muad dib
Rising Star
I too have noticed this issue, d*l*b, and have not found a good workaround for it. I didn't notice that it would sink to the bottom of the naptha container, but I can't get anything to precipitate out of it without letting it evaporate. That and then a re-x was the best solution I could think of.
d*l*b
Esteemed member
Well it seems to me that the yield is very low (at least with the material I was working with - "lower stem bark" ).
From 250g bark I managed to get 500mg fairly clean white xtals and 200mg xtals mixed with the goo. Product was obtained via freeze precipation. I did a re-x on some to try and clean it up, some xtals were obtained without re-x by scraping the layer of xtals that were sitting on top of the layer of goo.
Maybe the issue is that you had too much solvent, bearing in mind the small (it seems) amount of product in the bark?
It’s a shame that A. Confusa wasn’t as promising as it looks! The solvent was ridiculously white when pulled, but I guess that was mostly due to the large amount of the other substance that was there.
From 250g bark I managed to get 500mg fairly clean white xtals and 200mg xtals mixed with the goo. Product was obtained via freeze precipation. I did a re-x on some to try and clean it up, some xtals were obtained without re-x by scraping the layer of xtals that were sitting on top of the layer of goo.
Maybe the issue is that you had too much solvent, bearing in mind the small (it seems) amount of product in the bark?
It’s a shame that A. Confusa wasn’t as promising as it looks! The solvent was ridiculously white when pulled, but I guess that was mostly due to the large amount of the other substance that was there.
Sister, this might only work if it can be performed under alkaline conditions not acidic. Which iirc goes against the reductive methylation mechanism proposed here with the formaldehyde. Do not forget the pictet spengler. I made a similar post about this in another thread where someone proposed to use formic acid and formaldehyde.
Wish they mentioned what pH's they used. Please keep in mind also a lot of these kinds of papers 'fudge' yields and successes. Would be best to try on a simpler substrate first. Also I don't recall if they mention activation of the zinc prior to use but it may be implied.
People have tried a similar method starting from tryptamine and using stronger more exotic reducing agents with mixed success IIRC. Mostly failures and only one claimed success to my knowledge.
Also DMS would over-alkylate without a large excess of NMT. There are ways to mitigate this over-alkylation that are potentially OTC but I can't recommend someone not knowing what they are doing to look into them.
Wish they mentioned what pH's they used. Please keep in mind also a lot of these kinds of papers 'fudge' yields and successes. Would be best to try on a simpler substrate first. Also I don't recall if they mention activation of the zinc prior to use but it may be implied.
People have tried a similar method starting from tryptamine and using stronger more exotic reducing agents with mixed success IIRC. Mostly failures and only one claimed success to my knowledge.
Also DMS would over-alkylate without a large excess of NMT. There are ways to mitigate this over-alkylation that are potentially OTC but I can't recommend someone not knowing what they are doing to look into them.
Are secondary amines as prone to cyclization as primary ones? Have only read of pictet spengler as applied to tryptamine.
Yeah seems it is possible: