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HPBCD DMT very bioavailable sublingually under tongue, combo with tetrahydroharmine, Ayahuasca

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ava69

Rising Star
Update 6.6.2022:
Go to page 22 for full instructions with many pics:

"Journal: 50 Sublingual HPBCD DMT Ayahuasca journeys over a years time" is the 22 page topic in the Pharmahuasca section with many pics.

hxxps://mycotopia.net/topic/111790-journal-50-sublingual-hpbcd-dmt-ayahuasca-journeys-over-a-years-time/
or you can go to this link, it has all the pics for welcome guests.

:!: Important! This sublingual Ayahuasca will only work if you include 30mg HPBCD complexed harmine freebase along with your 60 to 150mg HPBCD DMT...again go to page 22 of this thread for full instructions. The 30mg harmine is needed TO ACTIVATE the DMT, otherwise this will not work.

And don't forget to take from 150mg to 300mg of PURE THH ORALLY around 45 minutes before you apply the sublingual HPBCD complexed harmine/dmt Ayahuasca under your tongue, hold for 15 minutes.

You can use orange or yellow DMT, it does not matter, it does not have to be white DMT. Be weary of that cheap China made THH from *iftmode...6 people here have already said when a bit of it is dabbed with a cue tip which has been pre wet in vinegar, then smeared on a paper plate under blacklight, that the smear does not glow blue (like THH is supposed to) but glows green, indicating the china made THH is contaminated with harmaline, in other words the synthesis was not complete....buy only from quality sources or make your own....this is covered on post #12 of linked thread above, go back to page 1 and read post #12, very important.
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HPBCD complexed DMT made very bioavailable sublingually under tongue, combo with tetrahydroharmine, Ayahuasca, 30 second formed alternative to fumarate salt.

Part 1: HPBCD complexed DMT experimental dosage, effects & duration
Part 2: receptorome chart & explanation
Part 3: Tetrahydroharmine (THH) effects
Part 4: Tetrahydroharmine receptorome similarities to mescaline; potentiates cactus & safety note
Part 5: chemist Patrick Arnold's HPBCD prohormones & bloodwork studies
part 6: Dr. Narang: "with sublingual" or "under the tongue" better than buccal, gingival & palatal
part 7: a little bit on my 70 Ayahuasca experiences, doses & visions
part 8: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble in water.
part 9: 20 minute visionary visit from a dead Aztec Shaman

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Part 1: HPBCD complexed DMT experimental dosage, effects & duration
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I found a thread here from 2012 entitled "Complexing DMT freebase for sublingual administration" After reading all 3 pages, I learned that no user in the thread attempted HPBCD complex to DMT, so I did an experiment to find out if it works.


I used a 7:1 gram weight ratio of HPBCD (hydroxy propyl beta cyclodextrin, molar weight between 1200 to 1500 g/mol) on auction sites and elsewhere, to DMT (molar weight = 188g/mol) in order to keep the molar ratio of cyclodextrin to host drug at a 1:1 molar ratio. What I did was place for example 30mg freebase dmt on a spoon, add 210mg of HPBCD powder on top the DMT, add many drops of water from a pipette, mix it all together for 30 seconds using a toothpick, then draw up liquid with pipette, place drops under tongue and hold for 10 minutes or so...I prefer 15 minutes. The DMT will dissolve into the bloodstream.

Strong effects at 5 minutes after the end of the 15 minute HPBCD DMT sublingual drug delivery under tongue: tryptamine rush/buzz & greatly elevated heart rate & pulse, dilated pupils...neon colorful visuals/visions...peak at 30 to 45 minutes, duration 60 to 90 minutes. 250mg tetrahydroharmine taken orally 3 hours earlier, transcendent combination, music sounded heavenly, the spiritual power of music.

I would imagine this might allow those who normally get nausea from oral preps to avoid the nausea. There is no burn under tongue, taste yes. I used this 3 times in one night over the course of several hours with THH, and my tongue was just fine, no burn or scarring. Felt just fine next day too. I experienced profound beauty and had visuals, very transcendent. Zero nausea.

Narang and Sharma mention in their 2010 sublingual paper that under the tongue pharmaceuticals can be 3 to 10 times more bioavailable than oral. HPBCD makes the non-water soluble DMT water soluble. It traps and delivers small molecules such as DMT extremely effectively across the mucosa membrane under the tongue, with it's high permeability (only 100 to 200 micrometers thick) and rich blood supply--shuttling the DMT directly to bloodstream.

Most studies recommend a 1:1 equimolar ratio of HPBCD to host drug for complexing.

This was using DMT cleaned up using a sodium carbonate wash. PKA of DMT is 8.75 or so, so please do not use a sodium bicarbonate wash -- it will eat up most of your DMT, as ph of bicarb is not high enough, it needs to be 1 to 2 points higher than PKA of DMT, at 11 or 11.5 or so is perfect, where 100% sodium carbonate PH is at, found in pool isle of home box store.

HPBCD is a new technology that allows freebase nonpolar drugs like DMT to be trapped by the cyclodextrin inner cavity which is composed of an inner "non-polar trap", and "outer polar cavity or cone" which allows the normally water insoluble DMT to be made 100% water soluble.

HPBCD is composed from a sugar molecule, it has been used to make scores of other non-water soluble drugs 100% water soluble and reach peak activity as measurements of the drug in the bloodstream indicated that all of the freebase drug was absorbed effectively.

Other examples of non water soluble freebase non-polar drugs complexed with HPBCD made water soluble: hormones, pregnisolone, etc.

Apparently, this also makes the DMT absorb very well if taken orally as well, possibly improving even the oral bio-availability substantially when taken with RIMA's to activate it, etc.
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THH or tetrahydroharmine can be taken orally (100, 150 to 200mg), my favorite in combo, while the DMT can be used sublingually, allowing the best of both worlds. No nausea felt. Have tried this in dreams several times in one night, and it works extremely well, tryptamine rush felt around 5 or more minutes after sublingual application, peak at 30 to 45 minutes, like an extended sub-breakthrough, excellent for long lasting transcendental contemplation and work. Best to limit to once a week or so, so no tolerance.

professor8 (found here from 11/1/2010):
Tetrahydroharmine (THH) has the ability to raise your vibration in a most powerful, yet subtle way. It brings a crystalline prismy texture to spice and adds a super clear watery dimension to Aya, like looking down through 10meters of shimmering Caribbean Sea on clear blue day. It brings a dimension of pure light to the entheogenic experience and encourages entities & intelligences of only the Highest Order. If one is not accustomed to perceiving these experiences with a spiritual perspective most of the nuances & subtleties THH brings on are overlooked and remain unseen and one would better enjoy Harmaline as a house painter chooses a roller over a brush, its about preference & choice.
I agree with his statement. Should add that music sounds quite incredible on a combo of 150mg or more of THH + DMT as tetrahydroharmine imho breaks down the filters or barriers in the mind, so that "mind at large" can be let loose, very similar to listening to music on cactus.

Mind at Large - Wikipedia

In TIHKAL, 300mg of tetrahydroharmine (THH) is equated by one psychonaut to the closed eye visionary (CEV) power of 100mg harmaline, but without all the nausea and dizziness. I totally agree. It glows blue under blacklight, like LSD or psilocin & has a metallic-like lingering taste with a 10.5 hour half-life.

Don't forget that this should improve the ORAL BIOAVAILABILITY of dmt when combined with a RIMA as well -- this technology has been used to potentiate these freebase drugs ORALLY as well -- this could potentially mean an Ayahuasca experience that is strong in potency.
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"Sublingual mucosa as a route for systemic drug delivery" by Narang & Sharma 2010:

As you can see from this sublingual viagra study, even 50 to 100mg doses can be administered under the tongue, the authors noting that less of the drug was required, and that it began working in only one half the normal time of an oral dose:

"The start of pharmacological activity after sublingual administration of sildenafil citrate in 30 patients affected by erectile dysfunction." by Siati & Franzolin 2003:

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Tetrahydroharmine on it's own will also yield the same type visions as harmaline, it just takes more of it. For example, around 300mg of THH will yield the same visions as about 100mg harmaline...even if the THH dose is split in two over several hours, the visions will still be apparent some time after the 2nd dose takes effect, the doses are additive.

THH in the caapi also seems to strongly activate the right hand hemisphere of the brain-- the side that performs tasks that have do with creativity and the arts, feelings, visualizations, imagination, holistic thinking & intuition, empathy, spirituality & connectedness. Researchers found that the right side of the brain lit up in brain scans of people who took LSD, mescaline, or mushrooms. This includes tetrahydroharmine. The world is largely moving in the direction of the Left Brain: technology and science. What the world needs is to move in the direction of Right Brain development.

Quote from TIHKAL by Dr. Shulgin "More studies on tetrahydroharmine are absolutely imperative."

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Part 2: receptorome chart & explanation
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This is why I suggest taking the DMT with tetrahydroharmine (as found in true Ayahuasca):

Thomas S. Ray, Psychedelics and the Human Receptorome (2010):
hxxp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009019
Breadth of Receptor Binding, 4.00=max or "off the charts", 0.00=min
LSD: 5ht1a = 3.73, DMT: = 0.00, psilocin = 2.88, mescaline = 3.61, 5-meo-DMT: = 4.00 (make up >80% of brain 5-ht)
LSD: 5ht1b = 4.00, DMT: = 0.00, psilocin = 2.19, mescaline = 0.00, 5-meo-DMT: = 2.41
LSD: 5ht1d = 3.70, DMT: = 3.91, psilocin = 3.40, mescaline = 0.00, 5-meo-DMT: = 3.48
LSD: 5ht1e = 2.62, DMT: = 3.28, psilocin = 3.03, mescaline = 3.16, 5-meo-DMT: = 1.72
LSD: 5ht2a = 3.54, DMT: = 2.58, psilocin = 2.14, mescaline = 0.00, 5-meo-DMT: = 0.98
LSD: 5ht2b = 3.11, DMT: = 3.91, psilocin = 4.00, mescaline = 3.97, 5-meo-DMT: = 0.69 (sensual & entactogenic)
LSD: 5ht2c = 3.11, DMT: = 3.42, psilocin = 2.52, mescaline = 0.00, 5-meo-DMT: = 1.55
LSD: 5ht5a = 3.64, DMT: = 3.16, psilocin = 2.83, mescaline = 0.00, 5-meo-DMT: = 1.84
LSD: -5ht6 = 3.75, DMT: = 3.35, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 2.73
LSD: -5ht7 = 3.77, DMT: = 4.00, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 3.69 (novelty & new ideas)
LSD: ---D1 = 2.34, DMT: = 3.51, psilocin = 3.37, mescaline = 0.00, 5-meo-DMT: = 2.38
LSD: -A-2A = 2.93, DMT: = 2.75, psilocin = 1.36, mescaline = 2.92, 5-meo-DMT: = 0.00 (aesthetic/beauty adrenal a2a)
LSD: -A-2B = 0.00, DMT: = 3.53, psilocin = 1.57, mescaline = 0.00, 5-meo-DMT: = 0.86 (aesthetic/beauty adrenal a2b)
LSD: -A-2C = 0.00, DMT: = 3.53, psilocin = 1.03, mescaline = 4.00, 5-meo-DMT: = 1.57 (aesthetic/beauty adrenal a2c)
2011 Thomas S. Ray study: Breadth of Receptor Binding, 4.00=max, 0.00=min
LSD: 5ht1a = 3.73, DMT: = 0.00, psilocin = 2.88, mescaline = 3.61, 5-meo-DMT: = 4.00 (these serotonin filters/gates/barriers/doors make up >80% of brain 5-ht & are broken down when 5-ht1a is agonized)
Dr. Nichols (Heffter.org LSD paper):
LSD has very strong potency in blocking the action of serotonin. LSD is strongly "anti-serotonin". The morpholide lysergamide cousin had only about 1/10th the potency in blocking serotonin. Of the 5 diferent dialkylamides we studied LSD was the most potent and specific serotonin antagonist. 5-ht1a makes up >80% of brain 5-ht receptors
As we go thru day to day life, the 5-ht1a brain serotonin filters (gates, or day to day survival filters as I like to call them) which make up over 80% of brain 5-ht are in place so that we will not be overwhelmed by the perception of the way things would appear to an un-filtered mind, or "Mind at Large" as Aldous Huxley describes it in "Doors of Perception" as "infinite or eternal". He also referred to the visions as coming from "the other world" in his book "Moksha". I prefer to think of it in similar terms as well "the spirit world" or "the other world".

5-ht1a inhibition by entheogens (in green above) theoretically cause this filter system to be lifted, and the infinite mind to manifest in combination with oral dmt with the tetrahydroharmine providing the 5-ht1a inhibition & additional adrenal system agonization (A2A thru A2C), just as bufotenine in snuff's provide the 5-ht1a inhibition combined with the dmt in the snuff's, resulting in a 3 hour experience ie both examples of Teamwork on how these entheogens are used traditionally in the Amazon.

Thomas S. Ray's study shows a value of 3.57 at SERT for Ibogaine (4.00 is max). Ibogaine has been shown to inhibit serotonin transporter (SERT) noncompetitively, in contrast to all other known inhibitors, which are competitive with substrate. Ibogaine inhibits both serotonin and dopamine reuptake transporters, it is an SDRI or serotonin & dopamine reuptake inhibitor. Tetrahydroharmine is a serotonin reuptake inhibitor, it is an SRI found in caapi. In other words, both are strong serotonin reuptake inhibitors which inhibit over 80% of brain 5-ht at 5-ht1a.

In contrast, as an example, Cocaethylene (coca leaf tea bags soaked in wine, the orally active & potent ingredient formed in the liver from cocaine + ethanol in the 1860's "Vin Mariani" wine popular with both Popes, Thomas Edison and scores of other famous people) increases the levels of serotonergic, noradrenergic, and dopaminergic neurotransmission in the brain by inhibiting the action of the serotonin transporter, norepinephrine transporter, and dopamine transporter. These pharmacological properties make cocaethylene a serotonin-norepinephrine-dopamine reuptake inhibitor [SNDRI; also known as a "triple reuptake inhibitor"].

Cocaethylene has a higher affinity for the dopamine transporter than does cocaine, but has a lower affinity for the serotonin and norepinephrine transporters. In McCance-Katz et alia's 1993 study cocaethylene "produced greater subjective ratings of 'High' in comparison with administration of cocaine or alcohol alone."

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Part 3: Tetrahydroharmine effects
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The Ayahuasca closed eye visions using 100, 150 to 200mg tetrahydroharmine or THH and HPBCD complexed DMT (30mg on up) together surpass in magnificence anything I have ever seen in reality or in works of art.

With open eyes, all spiritual things such as nature, art, female form, beauty, joy, take on significant meaning with infinite beauty, just like with cactus or LSD. Extraordinary beauty is manifested with open eyes and with the visions one sees with closed eyes. Impossible neon-like colors are seen that don't exist on this Earth.

The existence of a higher spiritual plane is recognized to which insight can and must be gained, yet it does not reject the mundane reality as inferior or empty. This joyous embracement of the world of form leads to words like infinite pleasure, beauty and joy. This loving reappraisal of the worldly forms leads the way to higher divine planes.

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Part 4: Tetrahydroharmine receptorome similarities to mescaline; potentiates cactus & safety note
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A little off topic, but I think tetrahydroharmine is a pretty special compound. I've used 250mg of it to potentiate cactus to very strong levels, it makes a 12" medium san pedro cactus tea which may contain around 250mg mescaline feel like an X-large 12" thick san pedro cactus containing around 400mg mescaline. It makes a 12" thick bridgesii cactus feel closer to a tea made with a 12" bridgesii cactus along with an extra 6" piece.

In the data I've seen for THH, it strongly blocks serotonin just like cactus, but also agonizes the adrenal A2A thru A2C receptors (the receptors associated with aesthetics & beauty), just like mescaline has been shown to do receptorome wise, explaining perhaps why they "overlap" so well. THH being able to make mescaline in cactus feel much stronger than it really is. Anyone who has ever taken cactus or high dose THH knows the appreciation for beauty experienced is "over the top".

But you have to stagger the THH from the cactus by taking the tetrahydroharmine around an hour after the cactus is taken, that way any minor maoi's or rima's in the cactus won't interact with the SRI which is THH, which can result in a faster heartbeat for a few hours which has happened to me before...so long as you take it later, it potentiates the cactus quite incredibly...it feels like I've taken 400mg of mescaline containing cactus tea when it's really only 250mg mescaline containing cactus, and they both lasts around 6 hours with super strong activity, so they wind down at around the same time. I have around 7 months experience combining the two, giving myself around 2 weeks apart from journeys.

It works so well, I won't take cactus any other way from now on. I get much more mileage from cactus this way. Visuals and visions are insane, music is so good sounding, you would think you were an alien experiencing sound and music for the very first time, every instrument stands out on it's own, like hearing a track for the very first time. It's a game changer.

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Part 5: chemist Patrick Arnold's HPBCD prohormones & bloodwork studies
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A litte bit more on sublingual & nasal HPBCD complexed pharmaceuticals:

Several years ago, before "prohormones" were banned, there was a company called "Ergopharm" ran by chemist Patrick Arnold that made HPBCD complexed solutions of prohormones in a nasal spray & in a HPBCD complexed powder that was administered under tongue.

In 2001 Arnold's company introduced the prohormone 4-Androstenediol, under the marketing name 4-AD. 4-AD is a prohormone that is easily converted by the body into testosterone, and it sold well. He is the chemist who created hydroxypropyl-beta-cyclodextrin complexed diols such as Cyclo-Diol(TM) and Cyclo-Nordiol(TM).


I bought and used the nasal spray and it was very effective, had my testosterone level checked with a blood test at the local labcore one hour after administering the spray and it was 3,500 ng/dl ! when my normal level was 600ng/dl. Highest measured normal levels in men are around 1200 ng/dl. The blood test cost me $70.00. It had strong mental effects as well. The spray would cause the 4-ad to enter the bloodstream nasally, and convert to testosterone via enzyme activity.

Patrick Arnold also made a sublingual powder of HPBCD complexed 1-AD that could be grabbed from the bottle with a pre-measured scooper, and the powder held under tongue for around 10 minutes or so, sold just as well as the nasal spray, I tried the sublingual product he sold, and that again was effective.

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Part 6: Dr. Narang: "with sublingual or "under the tongue" better than buccal, gingival & palatal
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With Insufflation, sublingual or rectal, DMT is not broken down by monoamine oxidase.

See above paper from Narang et al, Intl J Pharm Sci, Vol 3, Suupl 2, 2011, 18-22:
"With sublingual or "under the tongue", the mucosea thickness is only 100-200, high permeability with rich blood supply, much better than buccal or gingival & palatal, 200, 250, 500 micrometer respectively, shuttling the drug directly to bloodstream." The DMT is not broken down via monamine oxidase whatsoever this way. It avoids the liver and first pass metabolism. The drug is rapidly absorbed via the rich blood supply vessels under the tongue rather than being broken down in the digestive track via the enzyme monamine oxidase. According to paper: "Sublingually administered drugs reach directly in to the blood stream through the ventral surface of the tongue and floor of the mouth. The drug solutes are rapidly absorbed into the reticulated vein which lies underneath the oral mucosa, and transported through the facial veins, internal jugular vein, and braciocephalic vein and then drained in to systemic circulation."

According to paper, "the absorption of drugs through the sublingual route is 3 to 10 times greater than oral route and is surpassed by hypodermic injection. Peak blood levels of most products administered sublingually are achieved within 10 to 15 minutes, which is generally much faster than when those same drugs are ingested orally." This has been my experience as well, after 10 minutes of sublingual under tongue application, 5 minutes after the 10 minute sublingual absorption, the DMT rush is felt, followed by 60 to 90 minutes of entheogenic activity. According to paper, "sublingual absorption of drugs is efficient. The percent of each dose absorbed is generally higher than that achieved by means of oral ingestion."

Smoked: If DMT is smoked, the maximal effects last for a short period of time (5 to 30 minutes, dose-dependent). The onset after inhalation is very fast (less than 45 seconds) and maximal effects are reached within about a minute.

Insufflation & Sublingual absorption via Oral Mucosa (under tongue): When DMT is insufflated (snorted through the nostrils) or absorbed sublingually the duration is markedly increased.

Injection: Injected DMT produces an experience similar to inhalation in duration, intensity, and characteristics.

Oral ingestion: DMT, which is broken down by the digestive enzyme monoamine oxidase, is practically inactive if taken orally, unless combined with a monoamine oxidase inhibitor (MAOI).
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Keep in mind that only a portion or "tail end" of the host molecule is needed to attach or fit into the cyclodextrin cone, and that's all that is needed to be "trapped". I attached a picture of this below. The cyclodextrins have toroidal shapes, with the larger and the smaller openings of the toroid exposing to the solvent secondary and primary hydroxyl groups respectively.

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Part 7: a little bit on my 70 Ayahuasca experiences, doses & visions
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FYI: The THH is an SRI (serotonin reuptake inhibitor with significant adrenal activity at A2A thru A2C receptors, similar to mescaline in that regard), it has super weak MAOI activity (see Wikipedia on tetrahydroharmine).

I looked up the data comparing RIMA activity of THH to harmine from a lab supplier who gave the data, and they referenced THH as only having around 1/100th the RIMA strength of harmine, practically non-existent strength as a RIMA. That would mean it would take 20,000mg of THH to equal 200mg of harmine in RIMA strength. Harmine & harmaline however have significant RIMA/MAOI activity.

P.S. I have not actually tried the sublingual DMT by itself, I always prefer it with THH taken orally about 1/2 hour before applying the sublingual HPBCD DMT under my tongue. THH will not activate the DMT at all, but the combo of the two (oral THH + sublingual complexed DMT) is my absolute favorite after trying this several times.

How to best describe THH or tetrahydroharmine:

THH alone (200 to 300mg) with open eyes = everything is brighter and extremely colorful, beauty enhancement is over the top...neon-diamondlike is my best description, like looking down thru several meters of clear blue ocean water on a bright sunny day, just like professor8 describes it. A study done once on the UDV found that brews with high levels of tetrahydroharmine were preferred over all other brews, they found the "dmt was not the main attraction" but actually brews high in THH, fascinating study.

With 250mg to 300mg THH, closed eye dream-like Ayahuasca visions actually form with closed eyes that begin with colored sparkles and geometric dots and ziggly lines in orange, green, and blue that dart around and then progress to the monochrome visions for 1.5 to 2 hours, These visions are WAY beyond 4k, and highly detailed. The DMT seems to add color and brightness to the visions. The DMT also of course adds strong psychedelic alterations & activity to the journey and enhances the quality of music in combo with THH, music sounds incredible as mentioned before for several hours, especially if you keep taking the sublingual DMT around once an hour for the next 3 hours.
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Years ago, I took DMT freebase (70 to 90mg) with harmine and THH pharmahuasca at least a dozen times, and found it mild at best (on a Shulgin scale of 1 to 5, they were all +3 experiences). I even tried to dissolve it into coca cola and citric acid in hot water to make it absorb better as the salt, but it only slightly increased the strength.

The sublingual HPBCD complexed DMT tried the other day was all encompassing and strong at only 30mg, very impressed, I can only imagine where stronger doses will carry this psychonaut.

After that I switched to taking 30 to 35 grams of Hawaiian psychotria boiled down to a couple oz, then added the harmine + thh to the 2oz of hot pychotria tea....well that blew my mind CONSISTENTLY for many years, as I continued to use it over 65 times! Most of the experiences were +4 to +5, very strong indeed, much stronger than the freebase used dmt.

This agrees with what I read from clearlight:
Clearlight experiments that involved several people found the leaf brew form superior to extracted actives, they found the leaf brews very strong and powerful & clairavoyant (+5 Shulgin scale), while they mentioned that the extracted actives were mild (+3 Shulgin scale) at best, even up to 100mg. Again, this is poorly understood.
Even Jonathan Ott found that in his 20 experiments posted in his book "Ayahuasca Analogues", that none of his later experiments with extracted actives quite matched the power of his 1st actual Ayahuasca brewed with caapi and good real leaf (experiment #1), he had no explanation for this. He did however find 70mg to be close to it, but still not the same.

However, at this point, I have noticed that ALL the dried Hawaiian psychotria is extinct, and is no longer available. So I am looking forward in dreams to oral HPBCD complexed DMT at around 60mg on up, and hoping this will do the trick, I'm sure it will after having experienced what I really love with the 30mg sublingual HPBCD complexed DMT.

I have read HPBCD complexing these non-water soluble freebase drugs to make them orally 100% water soluble should make it absorb very effectively in the body, so I do believe it will be possible to once again achieve very strong journeys, similar to the ones I used to have using strong water soluble psychotria leaf.

I often found the oral DMT too short as it would wind down after 90 minutes of taking the pharmahuasca, and I am very glad I found this new complexing method so that I can take a "sublingual dose" if I choose at 90 minutes, to extend the journey at least another 90 minutes, to get a full 3 hours of strong activity out of it, that is my goal, and I feel I am one step closer after having experienced the 30mg HPBCD complexed DMT experiment that was successful.
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1) This could also be used to make HPBCD complexed DMT drops which can be added to a hot water tea that already has (around 180 to 220mg) harmine and (150 to 250mg) tetrahydroharmine dissolved in it (using added crushed vitamin C or similar to dissolve) for a SUPER POTENT ORAL pharmahuasca exeperience. Mix it all together and take at the exact same time, just as the Shaman's do. This is how I used to take the Ayahuasca over 65 times I made using same ingredients mixed into 2oz of hot psychotria leaf tea filtered and boiled down to 2oz.

2) Don't forget the importance of tetrahydroharmine or THH, which is 2nd highest ingredient in Caapi made Ayahuasca...you will want to experience real TRUE Ayahuasca, which is a brew high in it (from 150 to 250mg, 250 to 300mg for intense visions):

My last time taking 300mg of THH alone, I saw the interior decorations of palaces, the checkered floors, the beautiful windows and furniture, the winding stair cases, I was blown away, I've seen sacred temples for religious worship, beautiful animals and super fine women, birds of all kinds. I even saw a world war two fighter plane in the same session, it looked like the famous supermarine spitfire in full detail. Caapi tells a story when you drink it with eyes closed, she teaches you things, the most beautiful "realistic visions" that no other entheogen comes close to showing you, these realistic visions go on for long periods.

THH with open eyes: everything is brighter and extremely colorful, beauty enhancement is over the top...neon-diamondlike is my best description, like looking down thru several meters of clear blue ocean water on a bright sunny day.

All of the closed eye visions for me begin with colored sparkles and geometric dots and ziggly lines in orange, green, and blue that dart around and then progress to the monochrome visions for 1.5 to 2 hours. These visions are WAY beyond 4k, and highly detailed. The DMT adds brightness and color to the visions, for example, animals seen will have colored patterning. It also adds strong psychedelic alterations to the journey. Music will sound very alien & incredibly good.

In one past journey, saw three beautiful naked woman dancers twirling in front of stone pillars that rotated slowly. Jungle scenes lit up by the moonlight, full of snakes and palm trees by the beach and lots of people I had known in my life in floating bubbles that were to the left and right of the scene, drifting up into the sky. Elephants from India embellished with vibrantly colored jhools (saddle cloth) and heavy jewellery and sparkling anklets. Detached female faces of breath-taking beauty with freckles. Waterfalls in the middle of the jungle.

With another session, saw barely dressed women wearing futuristic clothing and bikinis of some sort, dazzling in it's design. A spinning vortex made of blue color with closed eyes that opened up in front of me that looked like a wormhole of some sort, I travelled inside of it, and was dropped off on an island in the pacific with wooden Tikis all around the perimeter of a small culture. I saw a chalkboard full of mathematical equations and scientific discoveries drawn out. I flew like a bird for nearly a minute over what looked like Los Angeles, as I could see the homes with swimming pools and parks below me.

I've seen pyramids adorned with gold sheen, architecture of the past and future, Egyptian scenery, vast landscapes, medieval scenery, it goes on and on. Everything is brand new as if newly created. Very similar to the Ayahuasca visions encountered by Benny Shanon in "Antipodes of the Mind".

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Part 8: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble in water.
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Receptorome study: how traditional Ayahuasca & snuffs differ from dmt

For a visual high dose claviceps paspali (same fresh alkaloid profile as the fresh Mesoamerican Aztec/Mayan morning glory) ergot wine trip report prepared by LSD chemist Todd Skinner, reported in the literature: read Krystle Cole's 3 page report on page 2 post #32 of morning glory link above.

She saw "constantly rotating holographic Sanskrit or Arabic & Zodiac symbols, floating in a circle around Todd's head."
 

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Interesting read. This might sound silly but if the goal from the cyclodextrine is to solubilize the freebase DMT then why not just convert the freebase into its salt form and thus it will easily dissolve? Why doesn't DMT salt work for sublingual route?
 
Wow. This is amazing work that opens up a very interesting route.

Nice job ava!

Edit: Upon trying to read more on this topic, I see that this has been crossposted to several forums by someone who I presume to be yourself. A quote of yours on Mycotopia

Tregar said:
There is a new paper out indicating that a 1:1 or 2:1 mix of HPBCD (hydroxy propyl beta cyclodextrin, on auction sites and elsewhere) to DMT can be made by placing for example 30mg freebase dmt on a spoon, add 30 to 60mg of HPBCD powder on top the DMT, add around 2 to 3 drops of water from a pipette, mix it all together for 20 seconds using a toothpick, then draw up liquid with pipette, place drops under tongue and hold for 10 minutes or so, the DMT will 100% completely dissolve into the bloodstream
Could you perhaps link this paper?
 
Thank you Sidisheikh.mehriz, woolmer, Kumarajiva, Jagube & rido for comments.

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part 9: 20 minute visionary visit from a dead Aztec Shaman
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This is how I got into growing morning glory, thought would share as I feel it was more a message from the Aztec Shaman, also goes to show the visual power of high dose LSD made from ergot alkaloids, this really happened.

Over 20 years ago, girlfriend and I both dropped 10 hits each of super old 15 year old decomposed acid given to us by a dear friend, he had stored it in between the pages of a book all that time without using a baggie, when held in front of blacklight, only around 60% of each blotter glowed, rest decomposed. It had a sick feeling for the first 2 hours, but then it worked and skyrocketed us to a higher divine plane, it was very strong.

She and I both saw the exact same vision for 20 minutes straight which had formed out of the shadows cast by the fake Christmas tree lights onto the wall--a 20 minute "schooling" by an ancient powerful & spiritually prominent Shaman from Aztec era --- I have never had an experience like that ever again to this day--it was a once in a lifetime opportunity.

The Shaman sat on a living chair made of spirit animals (birds, jaguars, otters, pumas, macaws, toucans) that morphed into other animals constantly, to the left and right of him were centaurs (half animal below, half naked female above), the great Pyramid of the Aztec capital behind him, and he showed me the rise and fall of several civilizations throughout time--and what is even more amazing--is that we both saw the exact same vision.

The Shaman wore a huge beautiful headdress made of feathers and the detail of the 20 minute animated vision was beyond 4k, and extremely detailed--it was also the vision in which I saw snakevines behind the centaurs, and before the Shaman left us at the end, he motioned to me with his eyes to look to the right of the living room out the window into the patio area where I had an empty garden plot--he was trying to tell me to plant entheogenic plants in the plot--that spring, summer & fall I grew morning glory in that plot on a large wide & tall wooden trellis cemented into the ground.

His point in showing me the rise and fall of the different civilizations was that I believe he was trying to tell me that "if humanity is to survive, the only hope is a Spiritual Solution".

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Sidisheikh.mehriz said:
Interesting read. This might sound silly but if the goal from the cyclodextrin is to solubilize the freebase DMT then why not just convert the freebase into its salt form and thus it will easily dissolve? Why doesn't DMT salt work for sublingual route?
Great idea, I used HPBCD over salting, only because I have past experience complexing prohormones to HPBCD, I've been lifting weights since my early 20's. It's fast (30 seconds) and works well, as mentioned earlier, no burn or scarring, under tongue felt fine afterwards and next day.

I would encourage someone who has access to both to do a study and compare each method: HPBCD complexed DMT to the salt form.

Someone may want to eventually post a link to this from the Pharmahuasca section so others can have access to this thread, I would hate for it be buried forever.

30mg HPBCD DMT under tongue was quite strong, WAY stronger than 30mg DMT I have taken orally with RIMA: harmine & SRI: thh combo, as mentioned in sublingual viagra study above, much less of the drug is needed when used sublingually and it starts working in only 1/2 the time of an oral pharmaceutical.

Don't forget to take from 150 to 250mg tetrahydroharmine around 30 minutes before the sublingual under the tongue HPBCD DMT, music will sound incredible, divine transcendence and visions, very similar to cactus tea.

Here is a pic of my 1kg tub of HPBCD:
 

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Interesting.

At the same time, the post resembles tregar's writing style, with multiple quotes, references to Aldous Huxley's "mind at large" etc. Would be good to see a confirmation from others that the tek indeed works.
 
Jagube said:
At the same time, the post resembles tregar's writing style, with multiple quotes, references to Aldous Husley's "mind at large" etc. Would be good to see a confirmation from others that the tek indeed works.
Yes, while I did not want to mention it as I was not sure, I thought I had seen this user post under another name before and make some statements that were repeatedly questioned by respectable members but for which the user would give no reply. My memory is very faint on this matter and I do not remember what the arguments were about, but I agree with Jagube that it would be good to receive confirmation from others.
 
Very interesting read. Aside from the effects of THH itself, how does this method compare to using a more typical fumarate salt sublingually?
 
Rido, I spent the last hour pulling up many threads on "sublingual or nasal fumarate salt DMT", and they were all very dissapointing reads, whereas the several HPBCD complexed 30mg DMT experiments I performed were strong indeed--held under tongue for 15 minutes, 5 minutes later: rapid hearbeat, rapid pulse, dilated pupils, felt distinct tryptamine rush & buzz take over my body, neon colored CEV visuals. Felt elation, euphoria especially in combo with the THH which I had taken many hours earlier.

Music sounded very good, experienced profound beauty with open eyes & CEV's with closed eyes. The duration was long. I re-dosed more 30mg HPBCD complexed DMT every hour for the next 3 hours, it was a sublime experience. I should have gone even higher in dosage to gauge. The afterglow even after the 3 hour period was fantastic. I watched a movie and had a fantastic time.

Have no explanation for how well this worked, there must be something special going on with the complexed HPBCD DMT, I can feel that it all absorbs in less than 15 minutes, and it wastes no time in reaching the brain unhindered, very impressed with this route of administration.

Look forward to hearing from other experimenters, HPBCD is dirt cheap. I bought my 1kg tub for less than the price of two movie tickets over 12 years ago, had been sitting in my closet all that time, used it in the past for complexing pro-hormones for sublingual use, very effective I might add, been a weight lifter since my early 20's. I read other weight lifters were doing the same, so I copied what they were doing before pro-hormones were banned.
 
Note: If anyone get's anything out of this thread, to remember that this can be a SUPER ALTERNATIVE to making the DMT fumarate salt.

Keep in mind that making the fumarate salt of DMT is a somewhat long involved process with many steps, whereas using HPBCD, you can form a water soluble DMT compound in 30 seconds that can even be used orally with a RIMA: (example, harmine) and SRI: (THH) combination, with everything dissolved all together in a hot tea, all taken at the exact same time (just as the Shaman's do) for a powerful Ayahuasca, that will be quite potent orally. I've taken Ayahuasca over 70 times now over a period of many years, my favorite next to cactus tea.
 
Is HPBCD same thing as cyclic dextrine / "highly branched cyclic dextrine or is it a different thing? I'm googling what is available in my country and can't find anything with that exact term.
 
Tomtegubbe said:
Is HPBCD same thing as cyclic dextrine / "highly branched cyclic dextrine or is it a different thing? I'm googling what is available in my country and can't find anything with that exact term.
Tomtegubbe, thanks for question. HPBCD = Hydroxy propyl beta cyclodextrin, it was unavailable to public for a very long time, only to research companies. It may be hard to find in your country. I bought mine from a supplier of sports supplements 12 years ago. Try auction sites and elsewhere that may ship to you.

Highly Branched Cyclic Dextrin = a carbohydrate used by nutrition companies, not the same thing.
 
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