Look what I found - that makes me reconsider that idea that we all have a different trip on dmt every time, based on the time of day, and therefore how many serotonin receptors you have up and running - There are 5 or more types of 5HT / serotonin receptors, that can all vary in amounts in your body ...
And another article -
It quotes Strassmann's work apparently - so maybe it's old news,
"It is reported that the 5-HT1A and 5-HT2A receptors produce opposing cellular
responses and are often expressed on thesame cell [51]. In a subsequent study, Strassman
[24] used pindolol, a 5-HT1A antagonist, in combination with a sub-hallucinogenic dose of DMT (0.1mg/kg IV) and found a two- to three-fold enhancement of DMT’s effects (according to theHRS). Thus, it appears that the 5-HT1A is suppressingDMTs hallucinogenic activity."
...this means that another tryptamine extracted with dmt could act as a 5HT1A-blocker, enhancing the effects of dmt on 5HT2A's, and not acting as a MAOI at all.
... I do really believe it's all about our receptors that are present, as they are the 'levers' and 'locks' while dmt is just the "key" ... We are all born with a unique, genetically determined 'mix' of 5HT receptor types, that varies all the time, based on many things.
For eg - what if you have less 5HT1A's around in the night time - how would your trip go..?! Do we have more 5HTA1's made in teh morning than 5HT2-types?
And another article -
It quotes Strassmann's work apparently - so maybe it's old news,
"It is reported that the 5-HT1A and 5-HT2A receptors produce opposing cellular
responses and are often expressed on thesame cell [51]. In a subsequent study, Strassman
[24] used pindolol, a 5-HT1A antagonist, in combination with a sub-hallucinogenic dose of DMT (0.1mg/kg IV) and found a two- to three-fold enhancement of DMT’s effects (according to theHRS). Thus, it appears that the 5-HT1A is suppressingDMTs hallucinogenic activity."
...this means that another tryptamine extracted with dmt could act as a 5HT1A-blocker, enhancing the effects of dmt on 5HT2A's, and not acting as a MAOI at all.
... I do really believe it's all about our receptors that are present, as they are the 'levers' and 'locks' while dmt is just the "key" ... We are all born with a unique, genetically determined 'mix' of 5HT receptor types, that varies all the time, based on many things.
For eg - what if you have less 5HT1A's around in the night time - how would your trip go..?! Do we have more 5HTA1's made in teh morning than 5HT2-types?