Right I take no issue with the warning. I think you're right to bring this up because it might be something that someone in your condition wants to watch out for.
"Some cases of IBS can be initiated by infections in the gut, but after the immune system "wins" or the infection is wiped out with treatments like antibiotics, the immune system is somehow maimed or confused and attacks things it shouldn't like an allergic reaction."
I would be careful with this line of reasoning however. You're right in that it's the mainstream medical opinion about autoimmune diseases. But it's built on an informal fallacy (ie argument from ignorance). "we can't show an infection persists so it's not there". And far from being a philosophical nitpicking, i have textbook length resources on infections that frequently elude detection as it relates to "idiopathic" diseases. Even when it's known that that person suffered from said infection before treatment it can be notoriously difficult to diagnose afterwords. Lyme disease is a great example how nonsensical all of this has become. The mainstream asserts that PLDS (Post Lyme Disease Syndrome) is a disease caused by persistent autoimmune attack after the infection has been eradicated. The alternative is that low levels of microorganisms persist in dormant and chronic stages and continue to stimulate inflammation. This has been supported by both in vitro and in vivo research. And despite all the denigration by the former, the latter is more consistent with basic trends in bacteriology and immunology and supported by better evidence (especially since the former rests their argument in an informal fallacy which by definition isn't evidence).
I'm a little rusty on the topics so i can't break down the details of exactly what doesn't sit right in my gut about that perspective. But the first issue in my mind is the need for PAMP to stimulate a strong immune response. Much like a plant needs light to photosynthesize, immune cells need PAMP (bits and pieces of pathogens) to sustain strong inflammatory responses (sort of a bad analogy). The relationship between microorganisms and immune cells is dynamic. They track each other continuously. Coupled with the seriously redundant feedback pathways involved inhibiting abnormal responses, the whole "autoimmunity is an immune system gone haywire" idea really points to the confusion of reductionist scientists over that of immune cells. Back to the human as an ecosystem perspective. Humans don't just "break" like machines. They don't go haywire anymore than organisms in a forest just go full retard and start killing things. Everything is in response to a living need. In many cases an autoimmune attack is the result of biomimicry on the part of a microorganism. The reason these organisms are so hard to detect is specifically because, unlike their 20th century pandemic counterparts, they don't want to be found. The exist in very low numbers, in specialized niches, in variable morphologies, and they frequently express antigen that "looks" like the tissue they're infecting. The purpose of this is to induce self tolerance in immune cells and prevent their own destruction. Autoimmunity in this case is a compromise where the immune system says "i can't let this go unnoticed anymore. it's either autoimmunity, or unchecked infection". The antibodies or TCR's will bind both microorganism and healthy tissue. It's not a mistake but a calculated response. And in theory, to my knowledge, this should only happen when coupled with PAMP. Again a similar issue with Lyme where outer surface protein A (OspA) is immunologically cross reactive to human gangliosides on neurons (a consequence of the spirochetes affinity for nervous system tissue and desire to remain unnoticed). Like a mask it wears to blend in. This is a cause of peripheral nerve disorders like CIDP and other guillaine-barre syndrome variants. And again while it's been unjustifiably assumed that persistent nerve disorders follow successful treatment, the dormant antibiotic refractory cells that have been suggested to remain continue to release OspA suggesting they are the real source of continued pathology. So again, not the body being stupid. Rather, it's still trying to get rid of the little fuckers (which i should point out are uncultivable due to their dormant nature which has contributed to the delusion of "eradication" ). And I know IBS is not Lyme disease. Lyme is just a good window into the ideologies of chronic illnesses and one of my main references from personal experience. The truth is that we have just grossly underestimated the nature of chronic infections in general. We expect them to behave and be treated like those of the 20th century and before, but it's not so. They have a different survival strategy. I would seriously reconsider your "extensive testing" and the fact that you may have picked something up in Peru. Though I can't in good conscience tell you what to do about it as that is a very personal journey along very dark paths. But I'm certainly making more progress than I was sitting on my ass going "well the doctors said i should be cured by now. my immune system must be stupid".
Anyways sorry for that ramble. It's just one of my hot button issues. Only trying to help because I know the hopelessness of believing that some scientist with their infallible brain has deduced your immune system is functionally retarded. The irony runs deep. It is not so. The immune system will make less errors in treating illness than the conscious mind will because that's what it's adapted for. It is the master of its domain. Virtually all problems lie in bad functional support and the occasional worthy competitor.
Anyways, back to the issue at hand. That's really interesting that you say it's in fact the DMT. Have you tried other psychedelics? In that case I'm not so clear what the issue might be. I don't think it's related to the discussion above as far as your reaction to ayahuasca goes. Since I'm not aware of DMT being some broad spectrum antimicrobial. But like you said, being such a neurological "power house" i wouldn't doubt it was interacting with your condition in some way. I think gut disorders can be some of the most complex just because of the immense variability of the environment. I wish I had some better insights but I don't think anyone is going to give you anything better. It will just sort of have to come from personal experience what works for you and what doesn't. Even though we classify chronic illnesses as generalized entities, their context-heavy nature almost makes them idiosyncracies
