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"immune system, the intestinal mucosa, and neurology both in the gut and central nervous system."

This almost invariably implies infection or dysbiosis. Why it is not the default hypothesis at this point is beyond me. This is the case for a hell of a lot of diseases from CVD, to cancer, to alzheimers that we treat (poorly) with all sorts of immune disrupting drugs despite that they are more than likely sequela of active infections. There have been some articles out recently saying something like "we can't identify 99% of the microbes in the body". I'm not sure how accurate that number is but it gives some perspective on why our understanding of chronic disease has been such a failure historically. After all we are just ecosystems and nothing more. How could we exclude our microbiological constituents from any shift in the steady state when they are the foundation of that steady state? Yet this is precisely what we've done. Autoimmune diseases without offending agents. Neural plaques without bacteria to build them. Cancers that behave like intracellular parasites despite considerably less time to develop such survival strategies. Bodies that attack themselves from overnutrition? :roll: I guess billionares too self destruct because they don't know where to stash all their money. No way. All those things you pointed out about IBS are true but they have an underlying link in the global microbiome.

As for the pharmahuasca, the beta carbolines themselves are antimicrobial bringing me back to my earlier point about a "healing crisis". When an ayahuascero says you're "expelling 'demons'" sometimes it may be quite literal. But again this was just one suggestion of why it might not be a contraindication though it can't be proven in your case. It's just a not so uncommon scenario for people with certain "autoimmune" diseases to develop these sorts of sensitivities to antimicrobials. It could be a purely neurologic or metabolic phenomena as well and in that case you may just be shit out of luck until you heal. Maybe the build up of monoamines in a gut with your particular type of damage is bad? Maybe the impact of 5-HT agonists? But i believe you said DMT didn't bother. Is that because the route of delivery? Do other psychedelics do this when taken orally?

There are a too many potentials here to take any sort of speculation seriously. Chronic diseases span all disciplines of health sciences. They are extremely multidimensional and it can be very difficult to come across a single linear reasoning of why a certain event is occurring. There might be many suggested pathways. But which one is the major contributor? Or are they synergistic? And you really have to know that to understand if what you're dealing with is a healing crisis or a contraindication. I'll tell you, in my condition i physically can't get better without paying the price first. Pharma abx, herbal abx... it's all the same to me. Increase my dose 1/8 of a tsp and expect to stay home the next few days in pain. I'd hate to tell anyone that an abx is contraindicated in my condition because it can literally save their life. At the same time, i don't want to suggest that anything that hurts is healing. It can take a long time to tease out these nuances. And it can be really scary at times "am I having a heart attack or is that just a die off of bacteria in my heart??" "Is that a die-off in my gut or is it drug induced liver injury". All i can do is take it low and slow and rule out any concerns that a doctor might be able to rule out. Titrate my doses, one herb/drug at a time. See if the trend is to peak and then get better, or if i just get progressively worse. If you choose to pursue ayahuasca i would do that starting with b. caapi only. If not, i understand that too. It might not be the preferred medicine in this case. It might not be medicine at all in this case. Or it might be the key to your health. Actually healing a chronic illness is a long drawn out process of self-discovery, experimentation, humility, learning from failures and persevering. And you frequently have to dip into dark waters before you can understand whats truly beneath them.

<blockquote data-quote="Psilociraptor" data-source="post: 3800907" data-attributes="member: 32613">&quot;immune system, the intestinal mucosa, and neurology both in the gut and central nervous system.&quot; This almost invariably implies infection or dysbiosis. Why it is not the default hypothesis at this point is beyond me. This is the case for a hell of a lot of diseases from CVD, to cancer, to alzheimers that we treat (poorly) with all sorts of immune disrupting drugs despite that they are more than likely sequela of active infections. There have been some articles out recently saying something like &quot;we can&#039;t identify 99% of the microbes in the body&quot;. I&#039;m not sure how accurate that number is but it gives some perspective on why our understanding of chronic disease has been such a failure historically. After all we are just ecosystems and nothing more. How could we exclude our microbiological constituents from any shift in the steady state when they are the foundation of that steady state? Yet this is precisely what we&#039;ve done. Autoimmune diseases without offending agents. Neural plaques without bacteria to build them. Cancers that behave like intracellular parasites despite considerably less time to develop such survival strategies. Bodies that attack themselves from overnutrition? :roll: I guess billionares too self destruct because they don&#039;t know where to stash all their money. No way. All those things you pointed out about IBS are true but they have an underlying link in the global microbiome. As for the pharmahuasca, the beta carbolines themselves are antimicrobial bringing me back to my earlier point about a &quot;healing crisis&quot;. When an ayahuascero says you&#039;re &quot;expelling &#039;demons&#039;&quot; sometimes it may be quite literal. But again this was just one suggestion of why it might not be a contraindication though it can&#039;t be proven in your case. It&#039;s just a not so uncommon scenario for people with certain &quot;autoimmune&quot; diseases to develop these sorts of sensitivities to antimicrobials. It could be a purely neurologic or metabolic phenomena as well and in that case you may just be shit out of luck until you heal. Maybe the build up of monoamines in a gut with your particular type of damage is bad? Maybe the impact of 5-HT agonists? But i believe you said DMT didn&#039;t bother. Is that because the route of delivery? Do other psychedelics do this when taken orally? There are a too many potentials here to take any sort of speculation seriously. Chronic diseases span all disciplines of health sciences. They are extremely multidimensional and it can be very difficult to come across a single linear reasoning of why a certain event is occurring. There might be many suggested pathways. But which one is the major contributor? Or are they synergistic? And you really have to know that to understand if what you&#039;re dealing with is a healing crisis or a contraindication. I&#039;ll tell you, in my condition i physically can&#039;t get better without paying the price first. Pharma abx, herbal abx... it&#039;s all the same to me. Increase my dose 1/8 of a tsp and expect to stay home the next few days in pain. I&#039;d hate to tell anyone that an abx is contraindicated in my condition because it can literally save their life. At the same time, i don&#039;t want to suggest that anything that hurts is healing. It can take a long time to tease out these nuances. And it can be really scary at times &quot;am I having a heart attack or is that just a die off of bacteria in my heart??&quot; &quot;Is that a die-off in my gut or is it drug induced liver injury&quot;. All i can do is take it low and slow and rule out any concerns that a doctor might be able to rule out. Titrate my doses, one herb/drug at a time. See if the trend is to peak and then get better, or if i just get progressively worse. If you choose to pursue ayahuasca i would do that starting with b. caapi only. If not, i understand that too. It might not be the preferred medicine in this case. It might not be medicine at all in this case. Or it might be the key to your health. Actually healing a chronic illness is a long drawn out process of self-discovery, experimentation, humility, learning from failures and persevering. And you frequently have to dip into dark waters before you can understand whats truly beneath them.</blockquote>

[QUOTE="Psilociraptor, post: 3800907, member: 32613"] "immune system, the intestinal mucosa, and neurology both in the gut and central nervous system." This almost invariably implies infection or dysbiosis. Why it is not the default hypothesis at this point is beyond me. This is the case for a hell of a lot of diseases from CVD, to cancer, to alzheimers that we treat (poorly) with all sorts of immune disrupting drugs despite that they are more than likely sequela of active infections. There have been some articles out recently saying something like "we can't identify 99% of the microbes in the body". I'm not sure how accurate that number is but it gives some perspective on why our understanding of chronic disease has been such a failure historically. After all we are just ecosystems and nothing more. How could we exclude our microbiological constituents from any shift in the steady state when they are the foundation of that steady state? Yet this is precisely what we've done. Autoimmune diseases without offending agents. Neural plaques without bacteria to build them. Cancers that behave like intracellular parasites despite considerably less time to develop such survival strategies. Bodies that attack themselves from overnutrition? :roll: I guess billionares too self destruct because they don't know where to stash all their money. No way. All those things you pointed out about IBS are true but they have an underlying link in the global microbiome. As for the pharmahuasca, the beta carbolines themselves are antimicrobial bringing me back to my earlier point about a "healing crisis". When an ayahuascero says you're "expelling 'demons'" sometimes it may be quite literal. But again this was just one suggestion of why it might not be a contraindication though it can't be proven in your case. It's just a not so uncommon scenario for people with certain "autoimmune" diseases to develop these sorts of sensitivities to antimicrobials. It could be a purely neurologic or metabolic phenomena as well and in that case you may just be shit out of luck until you heal. Maybe the build up of monoamines in a gut with your particular type of damage is bad? Maybe the impact of 5-HT agonists? But i believe you said DMT didn't bother. Is that because the route of delivery? Do other psychedelics do this when taken orally? There are a too many potentials here to take any sort of speculation seriously. Chronic diseases span all disciplines of health sciences. They are extremely multidimensional and it can be very difficult to come across a single linear reasoning of why a certain event is occurring. There might be many suggested pathways. But which one is the major contributor? Or are they synergistic? And you really have to know that to understand if what you're dealing with is a healing crisis or a contraindication. I'll tell you, in my condition i physically can't get better without paying the price first. Pharma abx, herbal abx... it's all the same to me. Increase my dose 1/8 of a tsp and expect to stay home the next few days in pain. I'd hate to tell anyone that an abx is contraindicated in my condition because it can literally save their life. At the same time, i don't want to suggest that anything that hurts is healing. It can take a long time to tease out these nuances. And it can be really scary at times "am I having a heart attack or is that just a die off of bacteria in my heart??" "Is that a die-off in my gut or is it drug induced liver injury". All i can do is take it low and slow and rule out any concerns that a doctor might be able to rule out. Titrate my doses, one herb/drug at a time. See if the trend is to peak and then get better, or if i just get progressively worse. If you choose to pursue ayahuasca i would do that starting with b. caapi only. If not, i understand that too. It might not be the preferred medicine in this case. It might not be medicine at all in this case. Or it might be the key to your health. Actually healing a chronic illness is a long drawn out process of self-discovery, experimentation, humility, learning from failures and persevering. And you frequently have to dip into dark waters before you can understand whats truly beneath them. [/QUOTE]