Bancopuma, so glad you are part of the study! One tiny request...is there anyway they can do a study to simulate the way traditional snuff's are used in the Amazon? See below...this would mean something added to the dmt which would block serotonin like bufotenine (found in snuff's) which might possibly equate to the effects of around 90% dmt + 10% 5-meo-dmt together, or something similar from what I gather. Just thought since you would be given both seperately, why not a combination of mostly the dmt with tiny amount of 5-meo together (which would apply the addition of serotonin blocking/destruction of filters & ego awareness)
Plant "admixture" dmt has been shown in the recent Thomas S. Ray receptorome 2011 study shown below to not block serotonin like all the other natural oral entheogens, 5-meo-dmt & bufotenin. If reading the study correctly, it appears to be a "team player" in combination with something that blocks serotonin. It appears from the study that it must "give up" 5-ht1a agonism (80% of brain 5-ht survival/ego filters are then blocked) so that it can be super-potent (act in place of serotonin while it is being blocked by the other native team player plant) at the other 20% of brain 5-ht sites.
DMT is so super-potent at the "other 20% of brain 5-ht" that it far exceeds even psilocin in strength as you can see from the chart below, but again, in doing this, it has to give up agonism at the other 80% of brain 5-ht (5-h1a, which when agonized, blocks serotonin, breaking down the filters/gates/barriers/doors in the brain). The docking size of the molecule (like a key fits a hole) can only cover so much receptorome territory.
LSD scientist Dr. Nichols:
LSD has very strong potency in blocking the action of serotonin. The morpholide lysergamide cousin had only about 1/10th the potency in blocking serotonin. Of the 5 diferent dialkylamides we studied LSD was the most potent and specific serotonin antagonist.
LSD scientist and founder of Heffter institute (where his papers reside) Dr. Nichols:
5-ht1a makes up >80% of brain 5-ht...5-ht1a agonism blocks serotonin
The molecular docking size of the molecule can only "do so much" on it's own, where the teamwork factor seems to come in to play. The academic and doctors do not seem to be aware of this new receptorome study which points to the indigenous method of traditional use of dmt as an admixture to native plants which provide the additional serotonin blocking teamwork action.
From 2011 Thomas S. Ray binding study
Breadth of Receptor Binding, 4.00=max, 0.00=min
LSD: 5ht1a = 3.73, DMT: = 0.00, psilocin = 2.88, mescaline = 3.61, 5-meo-DMT: = 4.00
These 5ht1a serotonin filters/gates/barriers (that allow us to survive in the real world & possibly help to make up the ego) make up >80% of brain 5-ht according to LSD scientist Dr. Nichols. Caapi contains a serotonin blocker called THH, so Ayahuasca can also be included in the list of entheogens that target 5-ht1a (block serotonin) apparently...along with lsd, mescaline, mushrooms & snuff's which are mostly bufotenine + dmt. Aldous Huxley postulates that lifting of the brain filters allow "Mind at Large" to be let loose.
James Oroc's new book "The New Psychedelic Revolution, the Genesis of the Visionary Age", describes the differences between DMT and 5-meo-dmt (page 79, a New Earth?):
DMT opens up the mind's eye to the visionary experience--anything that can be seen or imagined can vividly exist in the DMT realm. In my lectures I correlate DMT to the sixth chakra in the kundalini system. At this level, while you can experience the existence of God in all its infinite myriad forms, there is still a separation between the subject and object, between you and the face of the divine. DMT is thus the endogenous source of the vast and rich realm of our archetypical mythology.
On the other hand, the other known endogenous entheogen, 5-meo-dmt, Nick Sand described to me as "The Void", noting that the phenomenological experience of this closely related compound is very different from that of DMT. This singularly powerful compound I correlate to the seventh chakra of the kundalini system--the crown chakra--the source of that indescribable event where all boundaries dissolve, and you and God become One.
The 7th shakra reveals an interconnected dimension beyond vision, thoughts, time, space--the transpersonal experience defined by Abrahaam Maslow and Stanislav Grof--which 5-meo-dmt accesses through an ego death so dramatic and instantaneous that it is impossible to find the vocabulary with which to relate the experience with the sliver of consciousness that returns, the classical mystic's dilemma.
To read the effects of combining 90% dmt with 10% 5-meo-dmt, see his vision here:
(Traditional Amazonian snuffs contain mostly bufotenine which is also a serotonin blocker)
Oroc's experiment of combining 5-meo-dmt with DMT sounds imho very much like a short beautiful transcendental Ayahuasca experience, from his book "Tryptamine Palace":
DMT + tiny amounts of 5-meo-dmt (perhaps theoretically similar to the serotonin blocking abililty of Native Amazonian snuff's composed of dmt and bufotenine):
As an experiment (and in a foreign land) I smoked the last of the Bufo alvarius venom (the story of whose collection is described within the pages of Tryptamine Palace) with some ‘regular’ DMT (extracted from Jurema Preta.). In the vast majority of my early nigerine (DMT) experiences, I encountered visual fields of ‘dots’ that would come together to form images, much like the pointillism style of painting developed by Georges Seurat or the Australian Aboriginal song-line paintings.
* With the addition of the 5-MeO-DMT containing toad-venom to the DMT however, the visual characteristic was completely different and totally unique to my experiences so far. On this occasion there was a complete lack of ‘dots’ or ‘points’ of any kind, the fine lines of the constantly changing imagery were like those painted with a single-hair brush on Tibetan thangkas and due to the overwhelming artistry of what I was seeing, I could only think of the vaulted ceiling of the Sistine Chapel in comparison.
Sistene Chapel: This was without a doubt the most ‘visionary’ experience I have ever been fortunate enough to encounter and I lay there with my eyes shut watching the most fantastic parade of the Collective Unconsciousness imaginable, wishing that it would never end, and as I sit here now I can not even describe one tiny corner of it, since every image in the multitude of imagery was in such constant motion that they defied all but a glimpse. And then moments later, like a tent collapsing when its ropes are cut, the vision is gone. Leaving only a struggle of words to explain it, since nothing before or after has come close to this experiences visual majesty.
This experience leads to the interesting question of selectively combining DMT and 5-MeO-DMT for a more visionary and somewhat less overwhelmingly transcendental experience. (Or for the other way around). This combining of the two endogenous entheogens is being tested in changa blends (reportedly at a 90% DMT to 10% 5-MeO-DMT ratio), while many Pharmahuasca urban-shamans are also adding 5-MeO-DMT to their ayahuasca-analogues to transform and deepen that experience. It seems likely to me that the combining of DMT and 5-MeO-DMT in various ratios and manners will only become more popular as the exponentially increasing number of psychonauts search for new psychological terrain to explore.
Study shows bufotenine (5-ho-DMT) found in snuffs agonize 5-ht1a (which in turn blocks serotonin):
Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture.
Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture - PubMed
5-HT1A agonist: All the tryptamine derivatives substituted in position 5 of the indol were potent agonists [5-HT, 5-CT, 5-MeO-N,N-DMT, 5-methoxytryptamine, and bufotenine (5-ho-DMT)],
whereas tryptamine, N-methyltryptamine, and N,N-dimethyltryptamine were poor agonists.
Amazoninan snuff: Yopo beans have been found to contain up to 7.4% bufotenin and 0.04% 5-MeO-DMT and 0.16% DMT. At up to 7.4 % (74 mg per gram) bufotenin, an effective 40 mg dose of insufflated bufotenin requires little more than 0.5 grams of beans.
Theoretically & subjectively, Anti-serotonin properties at 80% of brain 5-ht in combination with the psychedelic molecule acting in place of serotonin at the other 20% of brain 5-ht sites result in breaking down the gates/filters/barriers so that One's consciousness can possibly return back to the transpersonal realm (a different tuning frequency for consciousness).
Dr. Nichols
5-ht1a makes up >80% of brain 5-ht...5-ht1a agonism blocks serotonin
Thomas S. Ray, Psychedelics and the Human Receptorome (2010):
We currently understand the mental effects of psychedelics to be caused by agonism or partial agonism of 5-HT2A (and possibly 5-HT2C) receptors, and we understand that psychedelic drugs, especially phenylalkylamines, are fairly selective for these two receptors. This manuscript is a reference...
journals.plos.org
hxxp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009019
Breadth of Receptor Binding, 4.00=max, 0.00=min
LSD: 5ht1a = 3.73, DMT: = 0.00, psilocin = 2.88, mescaline = 3.61, 5-meo-DMT: = 4.00 (make up >80% of brain 5-ht)
LSD: 5ht1b = 4.00, DMT: = 0.00, psilocin = 2.19, mescaline = 0.00, 5-meo-DMT: = 2.41
LSD: 5ht1d = 3.70, DMT: = 3.91, psilocin = 3.40, mescaline = 0.00, 5-meo-DMT: = 3.48
LSD: 5ht1e = 2.62, DMT: = 3.28, psilocin = 3.03, mescaline = 3.16, 5-meo-DMT: = 1.72
LSD: 5ht2a = 3.54, DMT: = 2.58, psilocin = 2.14, mescaline = 0.00, 5-meo-DMT: = 0.98
LSD: 5ht2b = 3.11, DMT: = 3.91, psilocin = 4.00, mescaline = 3.97, 5-meo-DMT: = 0.69
LSD: 5ht2c = 3.11, DMT: = 3.42, psilocin = 2.52, mescaline = 0.00, 5-meo-DMT: = 1.55
LSD: 5ht5a = 3.64, DMT: = 3.16, psilocin = 2.83, mescaline = 0.00, 5-meo-DMT: = 1.84
LSD: -5ht6 = 3.75, DMT: = 3.35, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 2.73
LSD: -5ht7 = 3.77, DMT: = 4.00, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 3.69
LSD: ---D1 = 2.34, DMT: = 3.51, psilocin = 3.37, mescaline = 0.00, 5-meo-DMT: = 2.38
LSD: -A-2A = 2.93, DMT: = 2.75, psilocin = 1.36, mescaline = 2.92, 5-meo-DMT: = 0.00 (aesthetic/beauty adrenal a2a)
LSD: -A-2B = 0.00, DMT: = 3.53, psilocin = 1.57, mescaline = 0.00, 5-meo-DMT: = 0.86 (aesthetic/beauty adrenal a2b)
LSD: -A-2C = 0.00, DMT: = 3.53, psilocin = 1.03, mescaline = 4.00, 5-meo-DMT: = 1.57 (aesthetic/beauty adrenal a2c)
I cant wait to read it. 
