Isolated Harmala Alkaloids - Harmine vs. THH for anhedonia, which is best?

[jacobjerondin]

Hey everyone, new member here! I've lurked on this forum for quite a while now but only got around to making an account a couple weeks ago so I can finally join the community properly!

Anyway, my question relates to the harmala alkaloids, specifically harmine and THH. I've been dealing with some stubborn and fairly debilitating anhedonia for around 3.5 months now since abusing f-phenibut and phenibut. in case you're not familiar with them, these are GABAergic drugs that work somewhat similarly to benzos but they work on GABA B instead of GABA A.

Since getting off phenibut, I've been stuck with PAWS (post acute withdrawal symptom) and while a lot of issues have mostly faded, I still have the anhedonia. It's incredibly frustrating because it's destroyed my social life since I can no longer enjoy socializing nor can I be entertaining and engaging like I used to. I feel like a shadow of my old self.

I have been told that thh and harmine are both very helpful for anhedonia and I can buy the isolated alkaloids from the member selling them on Amazon, so I am just wondering which would be more helpful. I am a broke college student so I do not have a lot of money to spend, so I would prefer to just buy one unless they work best together. Also, what dosages should I use? I am planning to take them daily in small amounts. Finally, what roa is best? I understand that orally last longest and you need a much higher dosage, whereas sublingual is lower dosage but it wears off much faster right? Has anyone tried intranasal?

One last question I have is whether microdosing DMT with these maybe every few days or every day could help my anhedonia significantly more than just using them on their own? Lots of questions I know, thanks in advance for any and all guidance!

 

[Elrik]

My experiences don't exactly match your scenario, in particular I didn't try to use low dose single alkaloids to counteract acquired anhedonia. But I have worked to go beyond anhedonia and lack of emotion I was born with. Generally with full strength psychedelic trips of many variations.

With pure harmine, not the harmine/harmaline mix from P. harmala, I personally feel nothing. I can take half of a gram and feel nothing! That is not to say that microdosing on a daily basis will not have a cumulative or subtle effect, just that I myself haven't noticed anything.
With pure THH, taken in isolation, at 100 mg THH•HCl I did feel it. It seemed like a mood elevating antidepressant. There were no psychedelic effects and it was very well tolerated. It was not dramatic or profound, my assay journal summarizes that dose as "Enjoyable but if I had been dosed without my knowledge I wouldnt have known."
At 200 mg THH•HCl I got a stronger version of the same effect, but this level did give me some traces of psychedelic effect.
If I were to take one, and only one, alkaloid to make pleasure and emotion easier to experience it would certainly be THH and for daily dosing I would experiment in the 25-100 mg THH•HCl range. THH has the added bonus of lasting far longer.

If your life only allows for very mild and non-dramatic dosing to get you what you want I understand. But it you want faster and more dramatic changes I would suggest full strength psychedelic trips that include THH. You can read some of my largely relevant reflections Here, but in short I found oral DMT trips involving both harmine and THH to be life altering in regards to connecting to emotion, beauty, and pleasure.