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'Known drug-interactions' Wiki page
- Thread starter The Traveler
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Nathaniel
Nathaniel
i know this is somewhat of a dumb question but i wanted to ask anyway.
LSD + SSRI = bad idea? or not so bad? i have been taking an SSRI for almost 2 months and basically i am going to see Tool tomorrow
. i know that psychedelics and anti depressants don't mix but i have read some varying stories on here and i wanted to make sure. also i am kind of thinking this might be the last time i am able to see this band in concert so despite everything i figured i'd find out if i can make an evening out of it.
LSD + SSRI = bad idea? or not so bad? i have been taking an SSRI for almost 2 months and basically i am going to see Tool tomorrow
. i know that psychedelics and anti depressants don't mix but i have read some varying stories on here and i wanted to make sure. also i am kind of thinking this might be the last time i am able to see this band in concert so despite everything i figured i'd find out if i can make an evening out of it.
..it should make the LSD stronger..
if it isn't already on the list - SSRI+Harmine = BAD/VERY DANGEROUS (particularly Prozac)
.
if it isn't already on the list - SSRI+Harmine = BAD/VERY DANGEROUS (particularly Prozac)
.
tigerstrike92
Homo-divinorum
Cannabis + Salvia = Good! Great way to take the edge off of the pre-flight anxiety for salvia, which can be pretty rough at times.
DXM + Cannabis = Good. Great way to up the psychedelic aspect of dex.
DXM + Tobacco = Great. Dex really makes tobacco shine, brings out the best world of nicotiana.
DXM + NO2 = Very, Very intense. Too much for some people, but for others, euphoria.
DXM + EtOH = ?? unknown. I have done this a few times and been safe, but I was very careful and spaced my drinks out. I have read horror reports of people drinking to much on dex, and puking for upwards of an hour or two.
DXM + HBWR(LSA) = ?? It really increases the psychedelia of dex, brings some awesomely colorful visions, but be very careful. Not much is known about the interactions of these two. I would not go above 3 HBWR seeds in combo.
Salvia + EtOH = Terrible. Puke city.
DXM + Cannabis = Good. Great way to up the psychedelic aspect of dex.
DXM + Tobacco = Great. Dex really makes tobacco shine, brings out the best world of nicotiana.
DXM + NO2 = Very, Very intense. Too much for some people, but for others, euphoria.
DXM + EtOH = ?? unknown. I have done this a few times and been safe, but I was very careful and spaced my drinks out. I have read horror reports of people drinking to much on dex, and puking for upwards of an hour or two.
DXM + HBWR(LSA) = ?? It really increases the psychedelia of dex, brings some awesomely colorful visions, but be very careful. Not much is known about the interactions of these two. I would not go above 3 HBWR seeds in combo.
Salvia + EtOH = Terrible. Puke city.
Theobromine, a methylated xanthine found in chocolate and yerba mate, is a stimulant and psychedelic potentiator.
Low doses combined with psychedelics causes noticeable potentiation and empathy.
High doses have the potential to cause nausea and over stimulation, so start low and work up to a comfortable dose!
Theobromine + Caffeine = OK. Nice warm fuzzy sociable synergy.
Theobromine + Caffeine + Mescaline = OK. Definite potentiation and synergy.
Theobromine + Passionflower = OK, but don't use a lot of theobromine. I have had psychedelic effects with this combination, but also intense nausea and bronchial-constriction at higher doses.
Theobromine + Harmala = OK but do not use a lot of theobromine. A little goes a long way! Same thing goes here if you have a little too much of either theobromine or harmala expect nausea and vomiting. At appropriate doses however the synergy is very nice.
Theobromine + LSD = OK. Noticeable synergy and potentiation.
Theobromine + Mushrooms = OK. Noticeable synergy and potentiation.
Low doses combined with psychedelics causes noticeable potentiation and empathy.
High doses have the potential to cause nausea and over stimulation, so start low and work up to a comfortable dose!
Theobromine + Caffeine = OK. Nice warm fuzzy sociable synergy.
Theobromine + Caffeine + Mescaline = OK. Definite potentiation and synergy.
Theobromine + Passionflower = OK, but don't use a lot of theobromine. I have had psychedelic effects with this combination, but also intense nausea and bronchial-constriction at higher doses.
Theobromine + Harmala = OK but do not use a lot of theobromine. A little goes a long way! Same thing goes here if you have a little too much of either theobromine or harmala expect nausea and vomiting. At appropriate doses however the synergy is very nice.
Theobromine + LSD = OK. Noticeable synergy and potentiation.
Theobromine + Mushrooms = OK. Noticeable synergy and potentiation.
And some notes on interaction (Some taken from Trout's Notes on Some Simple Tryptamines 2nd edition, also some of my own personal commentary)
5-MeO-DMT + Harmalas - (Harmalas will significantly increase potency of 5-MeO-DMT. 40-60mg harmaline + 10mg 5-MeO-DMT orally is equivalent to 30-35mg oral 5-MeO-DMT by itself or 10 mg intranasally (see Ott 2001 Note that 35mg by itself was not active dosage to shulgin but was for ott)
LSD + Psilocybin - Strong synergy with Psilocybe mushrooms.
LSD or Mushrooms + Harmalas - Strong synergy/potentiation, first timers should take very small doses to see how they react and only raise gradually
Pharmaceutical MAOIs (daily predosing for days/weeks) + LSD - The MAOIs will significantly diminish or even block the effects of LSD
MAOIs + MDMA = VERY DANGEROUS! Potentially fatal (even changa with MDMA is really NOT recommended. Here's one discussion)
MDMA + SSRI = VERY DANGEROUS! Potentially fatal
Mushrooms + DMT - When DMT is smoked at the peak or post-peak of mushrooms, there is an extreme synergy that can make it for an incredible experience that can take one very very far! For some this is their favorite combo, for others not
LSD + DMT - Same as above. For some people they feel its better to smoke at the comedown, or some people dont like it at all because they feel LSD acts as an anchor and holds one down, preventing breakthrough
Salvia + DMT - Effects are dramatic but its not clear if there is synergy or more like additive effects.
Piracetam + Psychedelics/Amphetamines - Trout notes that justin case, toad and others have reported substantial increase in potency of phenetylamines (such as MDMA, mescaline, amphetamines) and suggest dosage is halved. Possible potentiation of tryptamines too. There is very little data on the pharmacodynamics and toxicity of this mixture, so care is adviced, even though due to low toxicity of tryptamines and piracetam by itself, its possible the toxicity of mixture is also low.
Ketamine + DMT/5-MeO-DMT/tryptamines - Some people suggest ketamine may smooth the entry int tryptamine space and some report incredible experiences. Special care is needed with ketamine due to it's potentially addictive nature and due to being dissociative/anaesthetic and increased risks of physical accidents. Justin Case's best results have been reported when k dose is kept low and tryptamine dose is solid but not excessive.
Nitrous oxide + DMT - When nitrous is inhaled immediately after dmt, its reported by some people to significantly enhance the experience.
Chlorpromazine + Psychedelics - Chlorpromazine substantially diminishes the effects of DMT, LSD and other similar molecules (see Moore et al 1975, Shah & Hedden 1978)
Benzodiazepines can be reduce an agitated rough/unpleasant trip but are generally not recommended if other non-invasive supportive care-taking can be done, because these substances will dull the consciousness and might prevent the tripper from learning from the hard experience and integrating it.
5-MeO-DMT + Harmalas - (Harmalas will significantly increase potency of 5-MeO-DMT. 40-60mg harmaline + 10mg 5-MeO-DMT orally is equivalent to 30-35mg oral 5-MeO-DMT by itself or 10 mg intranasally (see Ott 2001 Note that 35mg by itself was not active dosage to shulgin but was for ott)
LSD + Psilocybin - Strong synergy with Psilocybe mushrooms.
LSD or Mushrooms + Harmalas - Strong synergy/potentiation, first timers should take very small doses to see how they react and only raise gradually
Pharmaceutical MAOIs (daily predosing for days/weeks) + LSD - The MAOIs will significantly diminish or even block the effects of LSD
MAOIs + MDMA = VERY DANGEROUS! Potentially fatal (even changa with MDMA is really NOT recommended. Here's one discussion)
MDMA + SSRI = VERY DANGEROUS! Potentially fatal
Mushrooms + DMT - When DMT is smoked at the peak or post-peak of mushrooms, there is an extreme synergy that can make it for an incredible experience that can take one very very far! For some this is their favorite combo, for others not
LSD + DMT - Same as above. For some people they feel its better to smoke at the comedown, or some people dont like it at all because they feel LSD acts as an anchor and holds one down, preventing breakthrough
Salvia + DMT - Effects are dramatic but its not clear if there is synergy or more like additive effects.
Piracetam + Psychedelics/Amphetamines - Trout notes that justin case, toad and others have reported substantial increase in potency of phenetylamines (such as MDMA, mescaline, amphetamines) and suggest dosage is halved. Possible potentiation of tryptamines too. There is very little data on the pharmacodynamics and toxicity of this mixture, so care is adviced, even though due to low toxicity of tryptamines and piracetam by itself, its possible the toxicity of mixture is also low.
Ketamine + DMT/5-MeO-DMT/tryptamines - Some people suggest ketamine may smooth the entry int tryptamine space and some report incredible experiences. Special care is needed with ketamine due to it's potentially addictive nature and due to being dissociative/anaesthetic and increased risks of physical accidents. Justin Case's best results have been reported when k dose is kept low and tryptamine dose is solid but not excessive.
Nitrous oxide + DMT - When nitrous is inhaled immediately after dmt, its reported by some people to significantly enhance the experience.
Chlorpromazine + Psychedelics - Chlorpromazine substantially diminishes the effects of DMT, LSD and other similar molecules (see Moore et al 1975, Shah & Hedden 1978)
Benzodiazepines can be reduce an agitated rough/unpleasant trip but are generally not recommended if other non-invasive supportive care-taking can be done, because these substances will dull the consciousness and might prevent the tripper from learning from the hard experience and integrating it.
^You said MAOIs and DMT are dangerous lol ;]
lol oops, I meant MAOIS+ MDMA
ChaoticMethod
Eye of the Beholder
Anybody tried, or know if there is any danger, with mixing caffeine and harmalas?
I've got some changa but had to stop myself from trying it a couple of times because I had too much caffeine on the same day.
I've got some changa but had to stop myself from trying it a couple of times because I had too much caffeine on the same day.
^As stated already in this thread:
Daily caffeine users dont really have a problem with this for the most part. Some find it much too stimulating. Others need to completely stay away from it.
And on the other hand, I've found smoking harmala or changa after a lot of coffee seems to help curb the stimulation of the coffee and smooths it out a lot. It's quite nice.
So start with low doses and experiment and find what works for you.
Daily caffeine users dont really have a problem with this for the most part. Some find it much too stimulating. Others need to completely stay away from it.
And on the other hand, I've found smoking harmala or changa after a lot of coffee seems to help curb the stimulation of the coffee and smooths it out a lot. It's quite nice.
So start with low doses and experiment and find what works for you.
ChaoticMethod
Eye of the Beholder
۩ said:
Thanks, I kinda skipped over that part.
As for some of the combinations I've tried:
NO2 + LSD : OK. Very powerful. Be prepared to lie down and be somewhat paralyzed, depending on dosage.
NO2 + Ketamine: Ok. Amazing visuals. Out of body experience, very comfortable but no contact at all with the body.
DMT + MDMA + Ketamine: Ok. Out-of-this-world OEVisuals. The euphoria of the MDMA is present and the visual quality of the K synergizes with the DMT in a very strange way. I would suggest taking only small dosages with all of those three if you are to give this combo a try.
Amphetamines + LSD : Somewhat safe but...Makes the LSD less visual and a bit more difficult to handle mentally because of the stress caused by the stimulants. It can be an interesting mix if partying but I would try to avoid it if possible. At least try to get pharmaceutical grade stimulants and not dirty street pills.
I know this combo has already been talked about, but MDMA and LSD together is one of the most amazing synergy in terms of dancefloor experience...
I am bumping this thread to see if anyone else would like to comment on any of their favorite synergies.
Loads of synergy of combos seems to work well.
I wonder about the safety of SMOKED or VAPED harmalas in changa with kava.
However, many could respond differently to these so better always start low with new substance or unusual combination and slowly increase dosage.
I'd add: LSD plus amanita muscaria or pantherina = great synergy, tends to make the trip more challenging and more visionnary, more entheogenic also, but it is again harder than LSD on it's own.
5meo-DMT and Harmalas oral = this could be hard on some metabolism, or dangerous, but IME, a great form of pharmahuasca, more nausea than with N,N-DMT, but also more euphorie.
Iboga and LSD = very challenging in my experience so the LSD was probably very high (vial wash) with loads of noribogaine (2 grams RB every days for four to five days) in the system. I personnally wouldn't recommend it.
Iboga and canabis are great together, the iboga focus the train of thought from canabis while canabis relax the iboga (stimulant at low doses) experience.
As for aya or pharma, I like to add some tea or guyasa to it for stimulation, sometimes even a cup of french pressed coffee, never had anything bad.
Iboga and harmalas must be treaten with caution though in low doses, it seems like a very good combo though questionnably safe (in regards of mixing RIMA and SSRI).
Also, most medecinal plants like maca, cat's claw, spirulina, ginseng etc.. are generally very good to take in association with entheogens, which makes one more sensible or maybe more prone to self suggestion.
Ayahuasca and mushrooms are great together with chacruna or chaliponga.
I wonder about the safety of SMOKED or VAPED harmalas in changa with kava.
However, many could respond differently to these so better always start low with new substance or unusual combination and slowly increase dosage.
I'd add: LSD plus amanita muscaria or pantherina = great synergy, tends to make the trip more challenging and more visionnary, more entheogenic also, but it is again harder than LSD on it's own.
5meo-DMT and Harmalas oral = this could be hard on some metabolism, or dangerous, but IME, a great form of pharmahuasca, more nausea than with N,N-DMT, but also more euphorie.
Iboga and LSD = very challenging in my experience so the LSD was probably very high (vial wash) with loads of noribogaine (2 grams RB every days for four to five days) in the system. I personnally wouldn't recommend it.
Iboga and canabis are great together, the iboga focus the train of thought from canabis while canabis relax the iboga (stimulant at low doses) experience.
As for aya or pharma, I like to add some tea or guyasa to it for stimulation, sometimes even a cup of french pressed coffee, never had anything bad.
Iboga and harmalas must be treaten with caution though in low doses, it seems like a very good combo though questionnably safe (in regards of mixing RIMA and SSRI).
Also, most medecinal plants like maca, cat's claw, spirulina, ginseng etc.. are generally very good to take in association with entheogens, which makes one more sensible or maybe more prone to self suggestion.
Ayahuasca and mushrooms are great together with chacruna or chaliponga.
VisualAnemia
Chalgren
Large doses: 80mg+ vaporized freebase DMT in short timespans (several times a week) has caused me an significant ototoxicity, both painful and annoying, some days more frequent than others.
It reminds me of the peak of the DMT carrierwave before the complex auditory hallucinations take place and it comes and goes like tinnitus. I've encountered the same adverse side effect when using metocin (4-ho-met) back in the days, so the DMT could possible be a mere trigger to an old wound, haven't used DMT since my last report because of this health concern.
Never experienced this problem with DMT at "smaller" dosages around 40mg's with the same timespan (several times a week).
It reminds me of the peak of the DMT carrierwave before the complex auditory hallucinations take place and it comes and goes like tinnitus. I've encountered the same adverse side effect when using metocin (4-ho-met) back in the days, so the DMT could possible be a mere trigger to an old wound, haven't used DMT since my last report because of this health concern.
Never experienced this problem with DMT at "smaller" dosages around 40mg's with the same timespan (several times a week).
Dante
Rising Star
Mushrooms + NO2 = Amazing! For few minutes you are in a DMT like world. (I'd love to try LSD + NO2)
Mushrooms + LSD = I took the Mushrooms while coming down from the LSD and I didn't feel any effect whatsoever. (EDIT: You probably have to take lots of Shrooms to fight the tollerance)
Mushrooms + Alcohol = Bad idea, high chances to end up puking and feeling miserable.
Mushrooms + MDMA + Coke + Alcohol = Bad bad idea. I took the MDMA, Coke and Alcohol at the end of a Shrooms trip. Anxiety and profound guilt were felt in my whole body.
LSD + Alcohol = Great and jolly, but it makes the trip a bit blurry and less powerful. Don't over do it, your liver wont appreciate it!
LSD + Cannabis = It gives a bit of anxiety, although the effect of LSD is potentiated for a little while. Be aware, it's very hard to roll a spliff while tripping :d
LSD + MDMA = The only time I did it, I took the LSD a while after the MDMA. Everything was very smooth and shiny. Great dancing combo!
Mescaline + Alcohol = In high doses it's extremely confusing! Good chances to blackout and puke.
Mescaline + MDMA = Nice combo, but it wasn't enough to understand its effects.
Mescaline + MDMA + K + Alcohol = All in small doses. Not very clear what was affecting what.
MDMA + Alcohol = Quite nice, but do not over do it! If you have been drinking too much, you'll be hit by a train when the MDMA comes down.
MDMA + Cannabis = Very nice, but you end up smoking way too much.
MDMA + K = Some people love it, I don't. I don't like small bumps of K, so when I take it, it always end up taking over all the rest.
MDMA + Alcohol + Bufotenin + K + DMT = Stupid me. A mess that doesn't lead to anything. The visual effects are almost inexistent.
K + Alcohol = I heard it's not very safe. I did it few times and the day after I always felt miserable.
Bufotenin + Alcohol = Not a good combo. The Bufotenin's nausea will probably make you puke and the Alcohol will diminish the Bufotenin visual effects.
DMT + Alcohol = The Spice doesn't like Alcohol, you'll either wont remember or get a bad vibe.
Mushrooms + LSD = I took the Mushrooms while coming down from the LSD and I didn't feel any effect whatsoever. (EDIT: You probably have to take lots of Shrooms to fight the tollerance)
Mushrooms + Alcohol = Bad idea, high chances to end up puking and feeling miserable.
Mushrooms + MDMA + Coke + Alcohol = Bad bad idea. I took the MDMA, Coke and Alcohol at the end of a Shrooms trip. Anxiety and profound guilt were felt in my whole body.
LSD + Alcohol = Great and jolly, but it makes the trip a bit blurry and less powerful. Don't over do it, your liver wont appreciate it!
LSD + Cannabis = It gives a bit of anxiety, although the effect of LSD is potentiated for a little while. Be aware, it's very hard to roll a spliff while tripping :d
LSD + MDMA = The only time I did it, I took the LSD a while after the MDMA. Everything was very smooth and shiny. Great dancing combo!
Mescaline + Alcohol = In high doses it's extremely confusing! Good chances to blackout and puke.
Mescaline + MDMA = Nice combo, but it wasn't enough to understand its effects.
Mescaline + MDMA + K + Alcohol = All in small doses. Not very clear what was affecting what.
MDMA + Alcohol = Quite nice, but do not over do it! If you have been drinking too much, you'll be hit by a train when the MDMA comes down.
MDMA + Cannabis = Very nice, but you end up smoking way too much.
MDMA + K = Some people love it, I don't. I don't like small bumps of K, so when I take it, it always end up taking over all the rest.
MDMA + Alcohol + Bufotenin + K + DMT = Stupid me. A mess that doesn't lead to anything. The visual effects are almost inexistent.
K + Alcohol = I heard it's not very safe. I did it few times and the day after I always felt miserable.
Bufotenin + Alcohol = Not a good combo. The Bufotenin's nausea will probably make you puke and the Alcohol will diminish the Bufotenin visual effects.
DMT + Alcohol = The Spice doesn't like Alcohol, you'll either wont remember or get a bad vibe.
billydgator
Rising Star
1.25mg 25i-NBOMe complexed blotter + nn-DMT freebase + MJ = awesome!
about 2.5 hours into an 25i nbome trip i took some small blasts of spice, brought me from ++ to ++++.
about 2.5 hours into an 25i nbome trip i took some small blasts of spice, brought me from ++ to ++++.