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'Known drug-interactions' Wiki page

Migrated topic.
I have a variety of experience mixing various substances, here is a list of all of the substances I have combined in various ways:

Tobacco
LSD
Mushrooms
Raw Cacao / Theobromine
Cannabis / hasheesh
DMT
Harmalas
MDMA
Ketamine / MXE
2C-B
5-me0-DIPT
GHB
Piracetam
Mescaline
Caffeine
Ethanol

LSD interactions:

LSD + Cannabis + Tobacco = Good!
I mostly smoke spliffs, but I find spliffs (a 50/50 mix of cannabis and tobacco) To be quite pleasant at all periods of the LSD comeup. Usually my physical form is quite shakey and or cold during the LSD comeup, and cannabis warms me up and calms down any tension or shakiness. Spliffs induce a deep trance state for me, very pleasant.

LSD + Cacao = Good!
I haven't experimented too heavily with eating cacao on LSD, but I usually eat one or two handfulls of raw cacao nibs. I found the stimulation synergistic, very good for walking or running through the forest. I found that the cacao gets rid of the "shivers" I experience from LSD and warms me from the inside.

LSD + Ketamine = Weird/good.

LSD + Ketamine is definitely a strange combination. In my experience it lends itself to meditation because alot of the time the mind is too befuddled to properly draw a train of thought. I find this combination quite inarticulating, it's one of the few drug interactions that make me a bit of a "dumbass", and just puddle me on the floor. Lower doses of ketamine + lsd are good for dancing, higher doses, for trancing.

LSD + MDMA : Oh lordy! Good!

MDMA removes any negative experiences I feel with LSD. POWERFULLY beautiful combination! All aesthetics are increased 10x, music is beautiful and flowing, playing music is amazing, dancing is amazing. Cuddling, hugging, telling people you love them... yes, this is a winner.

LSD + Caffeine: Good!

I'm a bit of a coffee / mate junkie, so I find the combination quite synergistic. Smoking a spliff and drinking coffee on LSD makes me feel like all is right in the world and I can sit in meditation and take a good 30 minutes to drink my coffee and have my smoke. It lends itself to visual enhancement and incredible tingling sensations in the body, which for some people could make them quite restless, but I enjoy meditation on stimulants.

LSD + Mushrooms: I haven't experimented enough with this combination to say for sure. Only very small doses, and they were kind of hazy.

LSD + Harmalas: Good!

I must admit I'm a bit of a Harmala "fiend". I love them and I see no negative applications to them, pretty much, as long as you are physically safe. They potentiate the visuals of LSD, get rid of the shakes and nervousness, help me emotionally sort through things and make me warm and content and happy. This is a WINNING combination, especially with chocolate caffiene or spliffs. all very good in my books. Great for meditation, dancing, writing, drawing, or playing music.

LSD + Piracetam: Good!

I have been dosing piracetam daily for a few weeks now, and in that time I've done LSD twice. Definitely noticed that each time the piracetam VASTLY improves ability to articulate myself, ability to recall the trip and get into deeper meditative states. Piracetam also greatly helps my ability to write more clearly in my journals, improves my ability to play music and LSD enhances my musical creativity. All in all, very good combination.

LSD + GHB: Fairly good

I don't have enough concrete experience with this combination, but I haven't experienced negative interactions the few times I have done them. the GHB is very warm and mellow, although a bit of nausea or headache or spinny-ness can occur at higher doses, if everything is kept moderate it is much more pleasant than alcohol, although not quite as pleasant as MDMA.

LSD + Alcohol: So-so.

I don't enjoy alcohol in general, so I'm slightly bias. When I was younger (15-16) I would shotgun beers on LSD and that was quite nice, but any hard alcohol combined with LSD turns you into a flailing, falling idiot apologizing for making such a big mess.


TO BE CONTINUED/EDITED/UPDATED
 
MDMA and AM-2201: Nice high, feels good and very sedating, very happy and relaxed. But can be VERY hallucinogenic, only smoke a little! Bizarre and realistic and gory hallucinations (man with half a leg bleeding allover the place!) are possible, voices become distorted and merged and speak impossible ridiculous things. The hallucination is short lived.

MDAI and DMT: Vaporized hits of DMT seem harder to break through on, but the effect of the DMT seem prolonged. Strange visuals (small pinpoint kaleidoscope patters appear and dissappear), last for longer than the spice effects would last, by up to 25 minutes longer. Does not seem dangerous, but the fact it makes open eye visuals linger for so long is interesting...
 
Syrian rue (harmala {4 grams}) + mimosa tea (oral dmt {5 grams})+ mushrooms(3.5) = OK. Amazing combination. A breakthrough experience, but comfortable, the best aspects of huasca mixed with the best aspects of the mushroom, the mushrooms extend the experience more than just mimosa and rue alone. More immersive than mushrooms alone with the full range body high of the harmalas. Induced great positive vibes and euphoria (at least in me) (I used this combination on 2 seperate occasions, both at shpongle concerts, i was able to move comfortably, and the experiences were a few of the best ive had)

mushrooms 2-4 grams + syrian rue (4grams)= OK. Lasts much longer than mushrooms alone, and potentiates the mushrooms, so less are needed for a full experience. Shroomhuasca is not nauseating for me like ayahuasca or syrian rue and mimosa is. Less body load and usually no purge. the harmalas draw the effects of the mushrooms out for me. not just extend but draw out kind of like in the same way vaped harmalas "slow down" the effects of dmt and level them out a bit. Its hard to explain how it potentiates the effects yet smoothes them out at the same time. A combo well worth researching. (Ive done this 6 times, including my very first experience, i feel the info i presented on it is very reliable)

mushrooms + THC= OK i find the weed can pick up a trip that is either not strong enough, or alow you to revisit the trip on the comedown. I love to smoke a bowl when the trip is coming down to reminisce on it.

ayahuasca + THC=OK I find that smoking with ayahuasca is best only on the comedown, i have found smoking to be completely pointless when in the thick of the ayahuasca experience

edited to add info about dosage and frequency
 
here are my FAvourite two mixtures.
And family, please do put thought in when mixing, too much and you will probably have a PANIC Attack or worse. Peace.

LSD + Ketamine: EFFECTS vary with dose of course.
*More effect if ketamine is taken at end of LSD trip, when tired, there is less resistance.
Thoughts will float onto many plains, a sort of synesthesia, usually deep thoughts,

more like a vision of thought that keeps stretching out evolving,
the experience becomes more hallucinatory (Out Of Body/Mind),
normal physics can change ie. gravity, and with enough ketamine one will enter a Loop 'K Hole' it can be scary or very interesting if one Can LET Go, this is like a ride.

On Ketamine i have had many rooms change Completely only to return after,
and have visioned flying over mexican rain forests and have mexico call out to me like an animal, this dose can bring many revelations.

I recommend LSD + Ketamine, only for a person experienced with Ketamine. always start low first. :)


LSD + 2ce: My doses depend usually one or two good LSD tabs and 20mg of 2ce is plenty.
*This is a beautiful experience, so visual, not much thought, 'a crazy visual circus', i dubbed this mix the perfect 60's trip i cannot explain how visual it is. Maybe a little disorienting, this dose is like a show it does all the work best to flow with it.

The mix is like being inside a diamond of colour, i had food colouring spraying out my vision and filling the area like flying ribbons paint brushes, there are geometric patterns in grass, and audio is enhanced a lot but not noticed, until one listens to the same music straight.

I would recommend experience with both separately first.

As i have noticed 2ce has no body sensation mainly visual which is a very strange body sensation when visually tripping balls, a feeling as if the body is weightless, empty like a shell.

2ce must be taken after the LSD has kicked in, or it will just over ride the LSD completely, the LSD seems to give a weight or solidness to the body it grounds the body, and the LSD seems with myself and friends to stop the fast onset of 2ce which by itself causes a very spinning sea sick feeling in the onset.

I have noticed and this is a rule of thumb for me now, That 2ce is profound especially on LSD when not as much is needed!
But it seems only to work on a rested mind, i have partied and been up all night then taken 20 mg of 2ce on three separate occasions to feel absolutely nothing.
 
kratom + Harmalas = :(

i took a modest dose (4G) of kratom on the comedown of a anauasca adventure (rue + mimosa) and had one of the worst interactions ive ever experienced. MASSIVE headache, tremors, hot/cold flashes, and unreal nausea. as soon as the kratom effects began about 20 minutes in, all these terrible side effects built with intensity along with that familiar kratom feeling. I had read that MAOi/RIMA + kratom are a known bad idea, but figured the harmalas were done and out by the time i dosed the kratom 5 hours later. NOPE!!!! The nausea was gone after i purged the remaining kratom out (about an hour after i took the kratom i purged) but the headaches stayed for 3 hours, possibly more but luckily i was able to get to sleep and felt OK when i woke up. Took kratom again 24 hours after the ayahuasca and had no problems.

any other kratom users have a idea for safety timing? would i be ok to drink ayahuasca 24 hours after kratom? anyone have experience with regular kratom use and ayahuasca timing? i have some fresh harmine extracted from Rue and a beautiful cold water mimosa tea calling me, but am unsure of how long i need to be off the kratom before i can drink safely.


good combo - mescaline + anauasca (rue + mimosa)

nice euphoria from the mescaline plus the vision/headspace of the anauasca. typically i take the mescaline first and wait until the peak starts to fade, about 3 -4 hours after taking the mescaline. This combo takes away the fear and anxiety that can come from a higher dose of harmala/DMT combo.
 
2mg 5-meo-mipt + 8mg 4-ho-met + 10mg 4-aco-dmt=

A very well rounded and introspective tryptamine experience. Empathy/body affects of the 5-meo-mipt mixed well with the 4-aco-dmt, and the 4-ho-met bumped up the visuals a bit without the jarring intensity another 8mg of 4-aco-dmt would have brought.

10mg plugged MXE + 10mg oral 4-aco-dmt=

One of the most introspective, comfortable, quasi-entactogenic/euphoric, and deep combos I've experienced with synthetics. Definitely a superb use of MXE at low dosages. Smooths out any of the roughness 4-aco can present, but really at 10mg its nominal.

10mg MXE plugged + 130mg 25x kratom FS extract orally=

13 hours of deep, complex, and vivid dreaming. Excellent rest, and woke up feeling very refreshed (but that happens after any epic dream nights, i might add). Wish i could report on the awake affects of said combo, but i just was too damn sleepy. CNS depression w/ this combo should be taken into account, and kratom/mxe combos should be done carefully/responsibly. It did not seem unsafe at the dosages i used.
 
Weed was used in combination with all of these combinations.

MXE + Kratom: Each potentiates the other, can get very nauseating with high doses of either. Generally I take my kratom and then once I feel it coming on take very small bumps (<10 mg) until I'm where I want to be.

MXE + alcohol: makes me feel more drunk in my head, but keeps my body from feeling drunk. Again, I take one or two small bumps of MXE once I am already feeling drunk.

MXE + kratom + alcohol: very up-fucking. Walking and talking difficult, sweating, a lot of peeing. I would be very careful with this combination, it seems like it could really ruin your night, especially if you don't have a tolerance to sedatives like mine.

MXE + 4-aco-DMT: A fantastic combination. Used a small amount of mxe (~35 mg sublingually) and a middling dose of 4-aco-DMT (30-35 mg orally). The mxe completely blocked any sort of anxiety or weird body feelings, which are often a problem with tryptamines in my case. Seemed to keep my trip on the positive side, even when some weird shit happened.

JWH 210 + 5-meo-MIPT: unknown (large) amount of both substances used accidentally. I j-holed, started freaking out (j hole not fun if you don't want it), and then started tripping. I realized that the JWH really helped along the visuals of the MIPT, and was able to ride out the night despite severe physical discomfort. (worst leg cramps ever, constant urination)
 
Mid dose 2c-b with mid dose 5-meo-mipt=OK , A very enjoyable experience with an amazing electric body buzz that lasts a long time , fantastic synergy


MDMA+5-meo-mipt=OK , A very profound experience with high doses of each , it was very trippy with insane tracers and amazing rushes
 
had yet only


LSD 50 (0:00) + wine (+12:00) = some nice soft-coloured closed-eyes visuals:)

LSD 200 (0:00) + 50cl Vodka (+6:00 lsd peak passed) + one deep inhale of Vladivostok (chemical) hashish (+6:30) = immediatly after exhale - :shock: moving of walls, then blackout for 20sec, pulse rising and sweating, dissociation and loss of time and 3d space (like you are millions of atoms and every atom pins you in random direction), loose of every base in consciousness, thought loops (idea about idea), coloured italian guys laughing on that great idea about idea from the walls ... - all this during 1-2 hours, ... at (+16:00) still was hard to sleep because of light closed-eye visuals and 'pain' in the body (next morning awake - oh yeah it passed :want: )
but the experience was quite extraordinary so :|
(should say I am seldom not pleased with MJ)

Amphetamines after MJ - nothing bad

Also once upon a time extracted salvia with acetone and after it smoked 5 pinches of good buds and it was hard (cause I was thinking of nice relaxing) - like 1/10 of that LSD 200 + ... :thumb_dow


will update
 
A very good friend has told me, and i know he talks truth from experience that mixing


MD's (extacy's)

+

Opiates (ie. oxycodone or morphine etc.)


=


Bad response.

Bad body feelings/load, and anxiety, and loss of thought control, just a bad mix!

And my friend has much experience with opiates and different MD batches.

He has tried this mix twice and never again.

He was trying to take Opiates on the come down of MD.
 
I don't see anything about MAOI and SSRI's. I don't know how it would be effected smoked but for sure oral MAOI used in conjunction with SSRI's is dangerous, I would assume the same for smoked MAOI.

"using MAOI's within five weeks of discontinuing the serotonin selective reuptake inhibitor (SSRI) fluoxetine (Prozac) could lead to coma and death. Discontinuation of the other SSRI antidepressants also require a two to three week washout prior to MAOI intake."
 
16mg 4-HO-MET + 90mg MDMA

Absolutely fantastic , one of my favorite combos , I find the MDMA rush is potentiated quite a bit.
Psychedelic euphoria :D
 
Agree on 25i + DMT

Very little DMT took me very far, although i did get a creepy vibe from it so i didnt take it further than that ..


DOC + DMT was also very spooky but has great potential,

DOC + Ketamine +N20 was one of the most powerful expereince ive had, very cyperpunkish character.
 
12g cactus resin as per Houses tek made from approx 18g Peruvian Torch dried chips with 25mg intra-nasal MXE, several strong coffees and as required bonged cannabis.

The timing was as follows:

T=0 3g resin
T+3hrs 9g resin
T+6hrs- 25mg MXE insufflated.

3 strong coffees between T=0 to T+5hrs.

Very nice combination;I find that MXE allows me to really focus in on the effects of whatevers taken with it;at the time the MXE was taken the resin had me in a pleasant MDMA-like headspace with little visual action but 1 hour into the MXE the visual effects became apparent.Possibly just a case of this phase being due to appear but it felt like the MXE awoke this aspect of the mescaline and other alkaloids.Clear 4-5 hour peak which came in waves and a sense of a 'spirit' of the cactus being present.It seemed that the MXE was outshone by the mescaline but the synergy was excellent.

This is the first time Ive used mescaline in over 20 years and it felt really good to sample its flavour once more.I think 25g of this batch of Torch chips would give a strong experience.
 
2c-e + MDMA

12mg of 2c-e was taken on the come down of 140mg of MDMA + 70mg booster dose. Noticed a lot of potentiation of the 2c-e visuals so consumed another 12mg. Wife took just the 12mg primary dose and was floored, entering visionary states, having conversations with me that didn't happen, etc. etc. She's only tripped a few times on shrooms and once on LSD so it's possible she's especially sensitive to 2c-e. Also possible she had a lot of psychic garbage accumulated she needed to work through.

DOC + 2c-e

2mg DOC was taken with 6mg of 2c-e once the DOC had settled into a nice plateau. Body felt exhausted from the DOC and biorhythm felt out of tune (I took the DOC before breakfast so I'd be able to sleep) and the 2c-e seemed to draw extra attention to this. 2c-e visuals mixed nicely with the DOC and were potentiated. Body load was hard to escape and took my wife seducing me to get my mind into a happy place. If I repeated this I'd use a larger dose of 2c-e in an attempt to overpower the DOC stimulation. But I might not repeat it.
 
100mg of aMT and x amount of 25-i NBOMe. I won't say amount as it's pretty crazy but this combination was pretty amazing! The aMT gave me mdma like euphoria with slightly trippy visuals but when i added the NBOMe i was transported into geometric bliss. I couldn't see anything except fractals and patterns and the euphoria and body high was quite excellent.
 
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