Kokusaginine discussion

[shoe]

I just had a friend over at another forum, who seriously knows his stuff,
tell me that Kokusaginine doesn't have any MAOi or opiate like activity;
according to his research. It does activate 5-HT receptors though.

here at the nexus its generally rumored to be the compound that makes
MHRB orally active.

So, we've got to make up a new chemical that is found in MHRB and responsible for its
MAO inhibitation. (couldn't really care whether its like an opiate or not tbh)

 

[endlessness]

who said kokusaginine is responsible for mimosa MAOI activity? From where do you get the idea that it is rumoured here about it?

check this out:

Erowid Mimosa Vaults : Mimosa Active Without MAOI?

Mimosa Active Without MAOI?

www.erowid.org

This compound has never been shown AFAIK in mimosa. More likely mimosa's oral activity is from yuremamine, which is destroyed under basic and acidic conditions and hence why only CWE works for mimosa-only oral experiences (and why it doesnt show up in typical extractions)

 

[shoe]

From Skatole+other toxic alks in mimosa? Supplier Reliability? - Welcome discussion - Welcome to the DMT-Nexus

"I.4 "Kokusaginine"
When browsing around threads discussing jungle spice, inevitably you start running across people claiming that kokusaginine is likely the chemical responsible for Jurema's reported oral activty."

"Jonathan Ott seems to think that Mimosa hostilis is active without MAOI added. The ingredient, kokusaginine, which is morphine-like in structure, may possess MAOI properties..."

Which is why it is supposed to have opiate affinity. My bad though, that was a jump of reasoning.

 

[endlessness]

"I.4 "Kokusaginine"
When browsing around threads discussing jungle spice, inevitably you start running across people claiming that kokusaginine is likely the chemical responsible for Jurema's reported oral activty."

and then it continues:

" Generally these posters cite the 1999 Entheoegen Review article where Jonathan Ott and K Trout are asked their opinions on the matter. Unfortunately, these people apparently read no further than the second paragraph before leaping to this completely unfounded conclusion."




no problem though.. Its good to question about substances..

 

[shoe]

well, there are a few things i'd still like to know:

1) Does mimosa hostillis contain kokusaginine?
2) Can it be isolated
3) why is it not reccomended for human consumption?

 

[Phlux-]

perhaps we should be discussing Yuremamine ?

 

[shoe]

Phlux- calls a meeting of staff...

Personally I'm not really that interested in yuremamine, Its a prodrug for DMT. I would like to know whether it is a MAOi and responsible for mhrb's oral activity.
That's what interests me at the moment; It shouldn't be active orally since Monamineoxidase, like any enzyme, will destroy millions of DMT mollecules per second. enzymes are incredibly efficient nanomachines!

 

[polytrip]

There seem to be some MAOI's present in mimosa, but they're not destroyed by heat, so they could't be responsible for the oral activity of CWE's.
I think yuremamine just isn't destroyed by MAO in the gut as much as DMT is, as is the case with psilocin.

But we have another mystery added: acacia confusa, wich is also orally active.

 

[Spiceman]

Damn I will get in on this convo later.. i Gotta go.. just got an emergency call.. but I have alot to add to this discussion!> Godspeed all.