Metoclopramide against Nausea ?

[Observant]

Some people Say Benadryl (Anti Histaminic Drug) can eliminate Nausea and Bodyload , at least for 2cx's.
Its of a sedating nature which speaks against using it with LSA Extracts .

There is also this other Nausea Treatment my Doctor prescribes most often - Metoclopramide Metoclopramide - Wikipedia

Metoclopramide (INN) (pronounced /ˌmɛtəˈklɒprəmaɪd/) is an antiemetic and gastroprokinetic agent. Thus it is primarily used to treat nausea and vomiting, and to facilitate gastric emptying in patients with gastroparesis. It is also a primary treatment for migraine headaches.
It is available under various trade names including Maxolon (Shire/Valeant), Reglan (Schwarz Pharma), Degan (Lek), Maxeran (Sanofi Aventis), Primperan (Sanofi Aventis), and Pylomid (Bosnalijek). It was protected under U.S. patent (3177252) until 6 April 1982.

Metoclopramide was first described by Dr.Louis Justin-Besançon and C. Laville in 1964.[1] It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/5-HT4 receptor agonist.
The anti-emetic action of metoclopramide is due to its antagonist activity at D2 receptors in the chemoreceptor trigger zone (CTZ) in the central nervous system (CNS)—this action prevents nausea and vomiting triggered by most stimuli.[2] At higher doses, 5-HT3 antagonist activity may also contribute to the anti-emetic effect.
The prokinetic activity of metoclopramide is mediated by muscarinic activity, D2 receptor antagonist activity and 5-HT4 receptor agonist activity.[3][4] The prokinetic effect itself may also contribute to the anti-emetic effect.

A friend of mine suggested it could make the LSAs Effects also kick in much faster .
It appaerently also can cross the Blood-Brain Barrier so I wonder if there could be interactiions between the 2 Substances .


Any thoughts/experiences ?


Observant