For me its LSD by a wide and unequivocal margin.
Pharmahuasca using refined alkaloids comes next if, and only if, you dont count nausea and the flavor as uncomfortable
Next would be refined mescaline. It gives me essentially no nausea by itself or after harmine predose but it does give me faint arthritis lasting into the next morning after I finally sleep.
Next would be bark-tea style mimosahuasca, but it drops one notch lower if you get the 'bright idea' to heat a whopping big dose back up until the tannin dissolves and drink it hot
Next would be mushrooms. Theyre powerful medicine that I owe a lot too, they almost certainly changed my life for the better, but on the balance I always found them somewhat unpleasant.
Worst is cactus tea, for some reason cactus tea gives me arthritis all over my body no matter if I fast or not, prehydrate or not, etc. Doing just half a dose after harm(al)ine predose at least made it manageable.
[Technically the absolute worst was the time I passed out alone face down in a chloroform spill. I did get amazing blue and red visuals right before passing out, that was unexpected, but I probably nearly died and was sick and jaundiced for a week after and now live with the lingering notion that I'll some day die of liver cancer, so dont replicate it.]
I'm not sure about Salvia divinorum, all I really remember is panic, fear, and a female forest spirit :lol: