Mushrooms and zoloft effective for depression? Or mushrooms neutralised by zoloft?

[DreaMTripper]

Ive read various reports that this combo is safe however would it be effective?
My freind and I are going through a bout of depression at the moment, he takes zoloft I do not take anything apart from 5-HTP.
Im going to have a low-medium dose of shrooms soon in the hope of rebooting and healing myself, or at least lifting the depression a notch or 2 and mentioned to him and he is eager to try it however would the zoloft neutralise any beneficial effects that psylocibin could give him?

 

[Nathanial.Dread]

Many people report that SSRIs neutralize the effects of mushrooms, making tripping only possible at much higher doses.

5-HT and psilocin both competitively bind to the 5-HT2A, so if you have more 5-HT at any given time, a greater percentage of the 5-HT2ARs will be bound to 5-HT, which means less will be available for psilocin to work it's magic.

Blessings
~ND

 

[DreaMTripper]

Thank you ND