Science paper N,N-Dimethyltryptamine (DMT) Crystalline Products And Methods Of Making The Same

It's a patent.

It's written in a way that would be a pain to copy / paste over some of the content, but it seems like a very detailed description of various DMT salts. Haven't read through it yet.

 

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I finally got around to reading this; I can't recall where I found it. It looks like this isn't the actual patent but some sort of review of it that includes some or all of the patent. There's a surprising amount of typos and seemingly repeated information, and bureaucratically formatted. But here's my amateur translation:

The actual patent application was filed in 2021 and this review was written a couple years later in 2023 during some stage of the patent process. The founders of the company PSILERA are behind this patent filing. They claimed to invent a way to synthesize DMT freebase, and make several different crystalline salts out of it.

At the very end of the PDF there's some commentary that there wasn't sufficient unity between these two halves of the "invention" because neither process explicitly required the other. And that the freebase synth wasn't new. And another comment that they failed to pay more money in time for the review to verify the novelty of the salt formations. I'm not confident I interpreted the language correctly though.

I searched for the provisional patent # but couldn't find any results. I think the company abandoned this patent effort.

It has some cool information on fumarate, tartrate, maleate, and succinate salts in crystal form, as well as some drawings of the molecules and crystal structures.
Interestingly, for the fumarate salt, they produced different powder XRD data than a previous study. Could be polymorphic or differences between the ratios of dmt and fumarate.

 

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On reading the pdf, it strikes me as unpatentable prior art. [Phew, I managed to type that without using the term "bullshit"!]

I think the company abandoned this patent effort.

Rightly so - they hadn't invented or discovered anything, after all. It was just a rather feeble attempt at an intellectual property-grab, IMO.

 

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It was just a rather feeble attempt at an intellectual property-grab, IMO.

Absolutely. The company Psilera is sort of mysterious. Only other Nexus talk about them is related to a transdermal DMT patch they were developing. From their website, it looks like they've pivoted a bit to non-hallucinogenic psychedelic analogs, or something.

One of the co-founders and authors of the patent is speaking at a "psychedelic symposium" in November. It's close enough I could go to. At first I was really excited to connect with them, thinking members of the organization might be closet Nexians. But idk, seems like it could be the opposite, big-pharma with big money and no respect for the history of open source research and free use. And I thought visual effects was an integral part of something being classified as psychedelic, but idk.

If anyone has an interest in learning more about this company and we brainstorm some questions to ask I'd consider going to the symposium to meet the speaker. But after reading through the patent I'm not overly impressed with their commitment.

And idk whether to feel a little sorry for them. Like maybe this is legitimately a grass roots startup that is trying to crack open the door on medicinal declassification of schedule 1 psychedelics, and just stumbling through the legal hurdles. I prefer the state of Colorado's model anyway, where it's decriminalized and everyone is allowed to have it apparently. Psilera had to get special permission from the DEA to do their research.

 

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Thanks for the offer. It might be an interesting conversation, if you can get a good grasp of the speaker's academic background beforehand.

The main question I'd have outside of the science is whether to wear tie-dye rags or a grey investo-corp suit if you're hoping to get anywear near them.

Maybe they're a great person, it could be amazing

 

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The main question I'd have outside of the science is whether to wear tie-dye rags or a grey investo-corp suit if you're hoping to get anywear near them.

Lol yea pretty much what I was thinking. Everyone listed in their company page seems to have a PHD, and the symposium seems more tuned for industry insiders. On Psilera's website they invited anyone who wishes to meet her to email to setup a time.

 

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Thanks for the offer. It might be an interesting conversation, if you can get a good grasp of the speaker's academic background beforehand.

The main question I'd have outside of the science is whether to wear tie-dye rags or a grey investo-corp suit if you're hoping to get anywear near them.

Maybe they're a great person, it could be amazing

I dug into this a bit, here's the speaker's linkedin page with some of their qualifications, awards, publications, and patents.

Jackie von Salm, PhD - Psilera Inc. | LinkedIn

Experience: Psilera Inc. · Location: Greater Tampa Bay Area · 500+ connections on LinkedIn. View Jackie von Salm, PhD’s profile on LinkedIn, a professional community of 1 billion members.

www.linkedin.com

Some of the patents say issued and some say filed. It looks like one of the issued is also listed as filed. Anyway I looked up that one:

COMPOSITIONS OF MATTER AND PHARMACEUTICAL COMPOSITIONS
Issued October 25, 2022 US US 11,478,449 B1

It's about the transdermal and nasal applications for psychedelics. Has the formulations and everything. It also lists basically every psychedelic analog using the indole structure. I'm confused if they're suggesting they own all those molecules now lol or if they're just listing the potential molecules they could pursue. In the end they only listed formulations for DMT freebase, fumarate, and 4-aco.

DMT fumarate ( 18.0 % w / w ) was dissolved in deionized water ( 82.0 % w / w ) to afford a therapeutically effective aqueous gel vehicle for intranasal absorption at a suitable pH = 6 . The formulation of DMT fumarate gel can be administered via the nasal cavity in small volumes of between 0.04 and 0.50 mL for therapeutic effects . Potency analysis using tryptamine internal standard quantification revealed DMT freebase concentration of 135.5 mg / mL with no other degradation byproducts after storage for 106 days in dark conditions at room temperature .

This might be the only one a home chemist would be capable of, so it piqued my interest. 135mg of freebase in 1ml of fumarate water?! That doesn't quite sound right but if a nasal dose is 0.5ml that's more than breakthrough amounts of freebase. Has anyone tried dripping concentrated fumarates up their nose? Sounds too easy.