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N N-Dimethyltryptamine identified in methanol leaf extract of Alternanthera bettzickiana

Migrated topic.


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Recently published by Vidhya et al. 2015


The aim of the current study was to perform phytochemical screening, antioxidant and hemolytic activities of Alternanthera bettizicikiana leaves. Determination of the antioxidant nature of A.bettizicikiana was carried out by DPPH radical scavenging, reducing power and total antioxidant activities. Hemolytic activity was performed by Spectrophotometric method to know the toxicity of A. bettizicikiana extract towards human RBC’S. In addition, antimicrobial activity was performed by Kirby-Bauer disc diffusion method using Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and Salmonella typhimurium. Preliminary phytochemical screening was performed to hexane, chloroform, ethyl acetate, methanol and aqueous extracts of A. bettizicikiana that resulted in the presence of carbohydrates, oils and fats and absence of proteins and saponins. Among all the extracts, methanol extract shown 92% DPPH radical scavenging activity with IC50 value of 293.44µg/ml and also possess good reducing property and total antioxidant activity in the tests performed. Antimicrobial activity of methanol extract resulted in no zone of inhibition for the tested organisms. The quantitative analysis of total phenolic and flavonoids was estimated that resulted in 63mgGAE/g and 38.98mgQE/g of the extract. Further, GC-MS analysis was performed that detected N N-Dimethyltryptamine in methanol extract and FT-IR analysis identified presence of functional groups within the methanol extract of A. bettizicikiana. Therefore, the bioactive compound should be isolated in future studies and could be used as a safe and natural antioxidant.

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  • Vidhya_et_al_2015_Evaluation_of_in_vitro_Antioxidant_antimicrobial_activities_and_GC_MS_analys...pdf
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Judging by the structural formulae on p.1076, where they depict psilocybin and title it "DMT", and chloramphenicol hexadecanoate is depicted for "hexadecanoic acid", I find their results possibly questionable.

Still interesting, though.
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