Another data point...

First of all I have never been a fan of microdosing, i.e. taking a plant in a very small dose and going on with daily life, without marking sacred time/space. But datura stramonium somehow feels resonant to be used in this way.  Still, ingesting on an empty stomach is a requisite. Without adequate time after the last meal, it becomes very inefficient and practically wasted. Especially eating meat on the same day nulls the experience.