I'm unsure why vegetable oil was abandoned as a solvent by this community however there has been a recent push to use more green solvents. Vegetable oil to extract alkaloids has been mentioned in a older patents EP2475374A2 and KR20120093862A. This is the most accessible method of extraction and it seems.
Sodium carbonate saturated solution is alkaline (12.1 ph) enough for mescaline and vegetable oil is much easier to access then many other non-polar solvents people use. I needed to do a few clean up and separation of the oil layer but I don't have any glassware and did a complete noob/hobbyist extraction
There is a thread on DMT-nexus that shows mescaline acetate as soluble in isopropanol however I question if that is correct. I am not chemistry inclined so I may be wrong. However a paper shows that sodium acetate is almost insoluble in 1-propanol and 2-propanol is almost identical in properties just more toxic. Even at 30% water/1-propanol ratio sodium acetate is almost completely insoluble. So why would mescaline acetate be any different. Unfortunately I when trying to boil my isopropanol to dissolve the precipitate like people do with MEK I ended up losing 90% of my product in the waterbath so I'm unable to verify if I'm right this time. (too much to evaporate for only 300mg)
I'm sure this would also work with DMT acetate. In a old thread people mentioned losses due to dry root absorbing the oil however with a liquid to liquid extraction rather than a solid/liquid like what was attempted in the past this may might resolve that issue.
Steps to extracting Mescaline acetate.
1. Powder dry outer flesh of cacti.
If you want to use whole cactus I'd suggest a boil of the bulk material before and reducing the volume until a manageable volume of perhaps 50-100ml
2. Add a saturated sodium carbonate solution to the dry flesh 2x the volume.
3. Add the vegetable oil of your choice I'd suggest an oil high in omega 9. Sunflower oil was used in the past but choose high oleic sunflower oil. The properties seem to differ between the oils there are a few papers that go deeper into this. Olive oil is also good but more expensive. I choose canola oil since rapeseed soil isn't available here. canola is made from modified rapeseed soil.
4. I didn't use any heat so I followed the patents which say 30hours soak with mixing the two layers. I mixed every couple hours for 2 days at 20C. If heated this could be reduced to 1 hour to pull.
I did 2 pulls of oil which I believe is enough but if you want do as much as you'd like.
5. After separating the non-polar layer from the alkaline aqueous layer. I added a acidic aqueous layer to salt and pull the free alkaloids that should be in the non-polar.
I used 1-1 volume and did this step twice. I used white vinegar at 5%. Lower would likely have pulled less extra impurities but I didn't have ph paper.
6. I now have a acidic aqueous layer which is vinegar at 5%. I evaporated this and ended up with a goo after it sat for a while. which weighed 472mg
7. From here I placed the goo into a small glass vessel and placed cold 70% isopropanol and a precipitate formed. I rewashed the precipitate with fresh iso 5 times until it was a much lighter color. I collected the isoproponal washes and when dried weighs 134mg which I believe are mostly impurities/carbohydrates.
I messed up here and tried heating the isopropanol to attempt to dissolve the precipitate like I've read with MEK however the wax I used to close the glass dropped melted and I lost 90% of my product.
I don't have reagent to test the remaining material and it isn't enough for an allergy test so I'll need to reattempt this in the future and with more dry material.
This took me 2 weeks but used zero heat only at the end to evaporate final products I used open flame.
Sodium carbonate saturated solution is alkaline (12.1 ph) enough for mescaline and vegetable oil is much easier to access then many other non-polar solvents people use. I needed to do a few clean up and separation of the oil layer but I don't have any glassware and did a complete noob/hobbyist extraction
There is a thread on DMT-nexus that shows mescaline acetate as soluble in isopropanol however I question if that is correct. I am not chemistry inclined so I may be wrong. However a paper shows that sodium acetate is almost insoluble in 1-propanol and 2-propanol is almost identical in properties just more toxic. Even at 30% water/1-propanol ratio sodium acetate is almost completely insoluble. So why would mescaline acetate be any different. Unfortunately I when trying to boil my isopropanol to dissolve the precipitate like people do with MEK I ended up losing 90% of my product in the waterbath so I'm unable to verify if I'm right this time. (too much to evaporate for only 300mg)
I'm sure this would also work with DMT acetate. In a old thread people mentioned losses due to dry root absorbing the oil however with a liquid to liquid extraction rather than a solid/liquid like what was attempted in the past this may might resolve that issue.
Steps to extracting Mescaline acetate.
1. Powder dry outer flesh of cacti.
If you want to use whole cactus I'd suggest a boil of the bulk material before and reducing the volume until a manageable volume of perhaps 50-100ml
2. Add a saturated sodium carbonate solution to the dry flesh 2x the volume.
3. Add the vegetable oil of your choice I'd suggest an oil high in omega 9. Sunflower oil was used in the past but choose high oleic sunflower oil. The properties seem to differ between the oils there are a few papers that go deeper into this. Olive oil is also good but more expensive. I choose canola oil since rapeseed soil isn't available here. canola is made from modified rapeseed soil.
4. I didn't use any heat so I followed the patents which say 30hours soak with mixing the two layers. I mixed every couple hours for 2 days at 20C. If heated this could be reduced to 1 hour to pull.
I did 2 pulls of oil which I believe is enough but if you want do as much as you'd like.
5. After separating the non-polar layer from the alkaline aqueous layer. I added a acidic aqueous layer to salt and pull the free alkaloids that should be in the non-polar.
I used 1-1 volume and did this step twice. I used white vinegar at 5%. Lower would likely have pulled less extra impurities but I didn't have ph paper.
6. I now have a acidic aqueous layer which is vinegar at 5%. I evaporated this and ended up with a goo after it sat for a while. which weighed 472mg
7. From here I placed the goo into a small glass vessel and placed cold 70% isopropanol and a precipitate formed. I rewashed the precipitate with fresh iso 5 times until it was a much lighter color. I collected the isoproponal washes and when dried weighs 134mg which I believe are mostly impurities/carbohydrates.
I messed up here and tried heating the isopropanol to attempt to dissolve the precipitate like I've read with MEK however the wax I used to close the glass dropped melted and I lost 90% of my product.
I don't have reagent to test the remaining material and it isn't enough for an allergy test so I'll need to reattempt this in the future and with more dry material.
This took me 2 weeks but used zero heat only at the end to evaporate final products I used open flame.