SWIMfriend said:Still, it's "freebasing" that has been the trick that has allowed vaping plant alkaloids. Psilocybin can't be "freebased." At least, that's what better chemists than I have said.
Psilocybin is a zwitterion and thus can be freebased at its isoelectric point (net molecular charge =0) just as it can form salts with cations and or or anions depending on whether its net charge is negative or positive.
Benzyme once calculated the isoelectric point of psilocybin to be pH~4. In theory therefore one can make a changa mixture of a pH~4 to have freebase psilocybin. Problem is also that while the melting point is 220–228 °C, we do not know the evaporation point, that could easily be 400-500 °C.