Pure vaporised Salvinorin A doses of 12mg

[The Neural]

So what do you suggest happened with the dosage? What is your prediction? Less, more, inadequate?

As has already been suggested, my guess is that the rate of administration was significantly slower than us “recreational” users are used to.

On the other hand, if we assume the full dose of 12mg was vaporized and inhaled in 3 inhalations (if it wasn’t, then the amounts reported become rather meaningless), then at least one of those inhalations contained at least 4mg Salvinorin A.

A single inhalation of 4mg of Salvinorin A held for 30 seconds will produce a very intense, possibly strongly dysphoric experience.

I have no idea why the subjective effects were as they were.

Finally, my posts in this thread aren’t meant to criticize the scientific methodology of the study, but to remind people, as Vodsel has already, that a 12mg dose of Salvinorin A, either in pure form or in an extract, when administered in an efficient manner (which isn’t hard to do with extracts), is likely to produce an extremely intense and possibly deeply unpleasant experience.

Agree on all speculations you put forward. However, 2 points :

1. "I have no idea why the subjective effects were as they were."

We actually have no idea altogether on the subjective effects, they were never reported in a comprehensive manner in the paper, so to ponder on their degree would be meaningless. The quotes mentioned were only meant to be there to correlate with psychedelic measures on psychological concepts (dissociation = felt like being on another planet etc), not to provide a fully understandable context of what the subjects felt in the whole of the experience.

2. "[...] a 12mg dose of Salvinorin A, either in pure form or in an extract, when administered in an efficient manner (which isn’t hard to do with extracts), is likely to produce an extremely intense and possibly deeply unpleasant experience."

It may be likely if we make a linear prediction, that as the dosage goes up, the intensity increases. The paper shows that there may be a degree of saturation that would alter this linearity. My point on this is that we really don't know what 12mg would do (besides anecdotal reports), since no one dares to consume a quantity larger than 1-2mg. Maybe this study can form the basis of useful follow-ups with more conditions (fast onset etc).


In all probabilities, I found the fact that physiological responses were for the most part unaltered very reassuring, and the EEG findings to be extremely interesting in what SA does to higher-level cognitive functions.