Research Haphazard Oral Administration Thread (Salvine Tek)

[stuartroelke]

Can't wait to see V02.01 Stuart! Have been following this thread carefully, looking forward to following the new protocol and giving feedback!

Thanks! You've inspired me to start working on the update more consistently.

Interesting development regarding enzymes: some studies mention that CES1 is primarily (if not exclusively) found in the liver, while CES2 resides in the gastrointestinal tract. Why does that matter? I started to question how effective CES1 is at metabolizing salvinorin A, and wondered if maximizing absorption speed—even via the portal vein—would be effective. However, this development only further suggests that lymphatic absorption is key to avoiding metabolism. Inhibiting CES1 still seems impractical and/or unsafe, as it "is the most abundant drug-metabolizing enzyme in human livers." I'm no longer considering oils (like EVOO and C8) as effective ingredients for simpler formulations.

The logical route continues to be:
Phosphatidylcholine + water triggers the release of bile salts and forms an emulsification. This allows salvinorin A to rapidly incorporate into mixed micelles, which can then tranfer lipids + lipophilic compounds to entyerocytes before getting packaged into chylomicrons (lymphatic absorption to the bloodstream).

Adding a delay between lecithin (phosphatidylcholine) and Salvia divinorum powder—the current recommended method in "Crude" Salvine Tek V02.00—is important for maximizing absorption and improving consistency. A syrup likely won't be sufficient when compared to basic extract packaged in a specialized capsule system, so that is ultimately what must be done for "Pharma" Salvine Tek. Pill designs are now in the works.

 

[JosBoaz]

HUGE UPDATE AND WARNING—PLEASE DO NOT SKIP:

Unfortunately for the tek, today I have to admit that I’m extremely confused. I also feel debilitatingly ignorant. Took 1g lecithin (capsule), waited ~25 minutes, took another 1g lecithin, waited ~20-25 minutes (perhaps the longest I’ve waited), then drank 2g salvia powder. Meanwhile, my partner took 1g lecithin, waited only ~15 minutes, took 1g lecithin, waited ~20-25 minutes, and then took 2g salvia powder. I wound up tripping HARD, while they only felt it a little. I tried not to panic or cause anxiety, but I became a bit anxious. They dodged a bullet for their first time. Note: this was without ethanol, EVOO, or bile salts.

Hello Stuartroelke,

I have read your Salvine Tek V02.00 Thank you for making it publicly available in that format.

Earlier today, I acquired lecithin, but I was only able to find 1,200 mg capsules rather than the prescribed 1,000 mg (1 g). The lecithin is in liquid form inside the capsule, so I cannot simply remove 200 mg from it. I also ordered 200 g of pure soy lecithin powder yesterday, but it probably will not arrive for another week or so. Do you think I should wait until the pure lecithin arrives, or would using the full 2x 1,200 mg capsules be unlikely to cause any complications?

 

[stuartroelke]

Hello Stuartroelke,

I have read your Salvine Tek V02.00 Thank you for making it publicly available in that format.

Earlier today, I acquired lecithin, but I was only able to find 1,200 mg capsules rather than the prescribed 1,000 mg (1 g). The lecithin is in liquid form inside the capsule, so I cannot simply remove 200 mg from it. I also ordered 200 g of pure soy lecithin powder yesterday, but it probably will not arrive for another week or so. Do you think I should wait until the pure lecithin arrives, or would using the full 2x 1,200 mg capsules be unlikely to cause any complications?

That difference should be negligible. I've been using 1,200mg capsules lately because they were available locally. That information ought to be included in V02.01, so thanks for pointing this out. The major change you should be aware of is to wait 2-3 hours after a meal before starting the process (will be emphasized in V02.01).

Additional information for you and others:

As recently mentioned, phosphatidylcholine (PC—a component of lecithin) seems to be the key potentiator. This could be related to how it is metabolized during the hour before salvia powder is ingested (PC -> phospholipase A₂ -> LPC + fatty acids / enhanced enterohepatic cycling). Less than 1g of PC seems to negatively impact potency, and 2g of most brands of lecithin should contain at least 1g PC. From what I've read, additional amounts of lecithin / phospholipids / PC won't vastly increase absorption, though I haven't personally tested more than 3g lecithin and 1g PC. Larger quantities may also lead to stomach upset.

My discovery about using 1g PC was only recent. I initially thought that lecithin / phospholipid blends might be most effective due to tests with 500mg PC being inferior and less reliable. I was naively assuming that 2g lecithin = 500mg PC based on some sources. It was also incorrect to hypothesize that lecithin was better at trigger gut motility—capsules of pure PC behave simialrly. This discovery has led to substantial progress with development of Salvine capsules. My last three successful tests with Salvine involved a system of capsules.