not sure if i posted this before, but i posted this at the shroomery earlier:
"A potent inhibitor of INMT, which is a necessary enzyme for the synthesis of DMT and 5-MeO-DMT, is found in particularly high concentrations in the pineal gland. A bypassing or inhibition of the synthesis of this inhibitor might be responsible for trances and other psychedelic states achieved "without drugs" (Strassman 1990)."
this is likely because 5-HIOMT is one of the enzymes expressed in the pineal gland, not INMT.
note: DMT production occurs much earlier in the tryptophan metabolism pathway than serotonin and melatonin, as one byproduct.. and each pathway is irreversible.
"A potent inhibitor of INMT, which is a necessary enzyme for the synthesis of DMT and 5-MeO-DMT, is found in particularly high concentrations in the pineal gland. A bypassing or inhibition of the synthesis of this inhibitor might be responsible for trances and other psychedelic states achieved "without drugs" (Strassman 1990)."
this is likely because 5-HIOMT is one of the enzymes expressed in the pineal gland, not INMT.
note: DMT production occurs much earlier in the tryptophan metabolism pathway than serotonin and melatonin, as one byproduct.. and each pathway is irreversible.
