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Salvinorin A soluble in oils, lipids? Decarboxylation necessary?

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Rising Star
I have read that salvia doesn't readily absorb sublingually or orally.

Does salvinorin a need to be decarboxylated like thc or ibotenic acid? Is this perhaps responsible?

Furthermore, if it can't be absorbed easily as is, could it just be dissolved in a carrier like butter or coconut oil or even alcahol. Something similar to weed edibles, you don't just chew a bud or eat bho, you have to process it, could this be why people have little success?

Too bad I don't have any salvia to experiment with, hopefully soon.
Salvinorin A is active once in the blood, it does not need to be decarboxylated beforehand like THCA (more info here.)

As you say, Salvinorin A needs to be helped into the body. Below are variuos buccal methods used (some experimental):

1) The quidding method (chewing rolled up leaves). I don't believe anyone knows why it works (one of Sally's mysteries).
2) 75% ethanol seems to work by disturbing and burning your mucous membranes so Salvinorin A can get in. Not recommend.
3) Acetone
5) HPBCD complexation

There is also an experimental possibility that Salvinorin A could be orally active if combined with a Carboxylesterase inhibitor such as Thymeleaf Sandwort. This would be highly experimental and may not work or be outright dangerous. But if it does work in a safe manner we could be looking at something like "salviayahuasca" (one can only dream). Or one could smoke Thymeleaf Sandwort together with Salvinorin A (salchanga?). Again, this would be experimental as far as I know and one would need to be very careful and understand what they are doing and go very slow if they would pursue this.

I have to say that it is so beautiful to see that all this information is in the nexus. We are truly blessed to have this community and this space. There is a lot more information in the salvia forum section.

You're Welcome.
BTW I've noticed enhanced psychoactivity when leaves were quidded alongside 1 gram of CaCO3 (in the form of antacid tablets).

Have you heard of this thing called acid-catalyzed hydrolysis!?!?!?!? You should look into it sometime, as the dilute HCl in your stomach (pH ~1.5) may cause it to degrade rapidly, yet others have reported success with salvia teas.

Also, have you ever considered IR administration of a sally d solution incubated overnight at RT in 75% EtOH? Butt-chugging EtOH solutions is a safe practice if done so carefully; I'd recommend you not exceed 30-50ml of The EtOH, as it is a pain in the ass to administer and may interfere with the effects of salvia inebriation if consumed in excess. Intrarectal administration is a safe ROA to use, and is a helluva lot easier and healthier than drinking acetone and/or holding 75% EtOH solutions in your mouth for upwards of 5-10 minutes straight.
Loveall said:
There is also an experimental possibility that Salvinorin A could be orally active if combined with a Carboxylesterase inhibitor such as Thymeleaf Sandwort.
From another oral Salvia thread around here:
I have some of Twig Harper's Salv-A Syrup, and I am going to try it out for a week (unless it interferes with my math class I'm taking online).

For all those who are interested the ingredients are as follows (from the label on the bottle):

Salvia Divinorum (Salvinorin A, B, C, D, E, F)
Nigella Sativa (Thymoquinone)
Eugenol in a carrier blend of Sunflower, Nigella Sativa, and Olive Oils

Recommended serving size: 1/4 tsp - 1/2 tsp

Recommended use: 1 serving daily in the morning
Might be worth a try.
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