Scientific Articles on DMT/Ayahuasca/Psychedelics

[benzyme]

:thumb_up:
I like it. most interesting article I've seen in a while; rather obscure one too.

 

[JustATourist]

Preller, Katrin H., et al. "The fabric of meaning and subjective effects in LSD-induced states depend on serotonin 2A receptor activation." Current Biology 27.3 (2017): 451-457.


Highlights:

LSD-induced effects are blocked by the 5-HT2A receptor antagonist ketanserin
•LSD increased the attribution of meaning to previously meaningless music
•Simulation of the 5-HT2A receptor is crucial for the generation of meaning
•Changes in personal meaning attribution are mediated by cortical midline structures


http://www.cell.com/current-biology/fulltext/S0960-9822(16)31510-X

 

[dreamer042]

Serafetinides, E. A. "The significance of the temporal lobes and of hemispheric dominance in the production of the LSD-25 symptomatology in man: a study of epileptic patients before and after temporal lobectomy." Neuropsychologia 3.1 (1965): 69-79.

 

[dreamer042]

Putting this here for safekeeping/easy referencing. This is probably the best overview of studies on high dose melatonin available.

Cardinali, Daniel P., et al. "Therapeutic application of melatonin in mild cognitive impairment." American journal of neurodegenerative disease 1.3 (2012): 280.

Here's a direct link too: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560473/pdf/ajnd0001-0280.pdf

 

[dreamer042]

Smart, Louis. "Competitive inhibition of sodium-dependent high affinity choline uptake by harmala alkaloids." European journal of pharmacology 75.4 (1981): 265-269.

 

[Alev-Kev]

~ HOLY, TREASURE OF KNOWLEDGE!! So glad this is STICKY'd

 

[dreamer042]

Harmala/Beta-Carboline literature dump.

Astulla, Adil, et al. "Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities." Journal of Natural Medicines 62.4 (2008 ): 470-472.

Moura, Dinara Jaqueline, et al. "Antioxidant properties of β-carboline alkaloids are related to their antimutagenic and antigenotoxic activities." Mutagenesis 22.4 (2007): 293-302.

YH, Tse Susanna, I. Mak, and Benjamin F. Dickens. "Antioxidative properties of harmane and β-carboline alkaloids." Biochemical pharmacology 42.3 (1991): 459-464.

Im, Ji-Hyun, et al. "Antiplatelet activity of β-carboline alkaloids from Perganum harmala: a possible mechanism through inhibiting PLCγ2 phosphorylation." Vascular Pharmacology 50.5-6 (2009): 147-152.

Bemis, D. L., et al. "Anti-prostate cancer activity of a β-carboline alkaloid enriched extract from Rauwolfia vomitoria." International journal of oncology 29.5 (2006): 1065-1073.

Chen, Qi, et al. "Antitumor and neurotoxic effects of novel harmine derivatives and structure‐activity relationship analysis." International journal of cancer 114.5 (2005): 675-682.

Patel, K., et al. "A review on medicinal importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid “Harmine”." Asian Pacific journal of tropical biomedicine 2.8 (2012): 660-664.

Li, Shuping, Xuemei Cheng, and Changhong Wang. "A review on traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the genus Peganum." Journal of ethnopharmacology 203 (2017): 127-162.

Schenberg, Eduardo E. "Ayahuasca and cancer treatment." SAGE open medicine 1 (2013): 2050312113508389.

Sarkar, Sarita, and Kakali Bhadra. "Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach." Journal of Photochemistry and Photobiology B: Biology 130 (2014): 272-280.

Smart, Louis. "Competitive inhibition of sodium-dependent high affinity choline uptake by harmala alkaloids." European journal of pharmacology 75.4 (1981): 265-269.

Mekki, Laila. "Cytogenetic effects of crude extracts of Peganum harmala seeds and their effects on Vicia faba plants." Cytologia 79.2 (2014): 161-172.

Jimenez, Judith, et al. "Cytotoxicity of the β-carboline alkaloids harmine and harmaline in human cell assays in vitro." Experimental and Toxicologic Pathology 60.4-5 (2008 ): 381-389.

Moshera, M., and E. Seliem. "Effect of harmal seeds on heat stressed chickens." Journal of American Science 7.12 (2011): 606-611.

Diwan, Saddam Yahya. "Effect of Peganum harmala methanol extract on liver and kidney of mice administered MTX drug." Journal of Al-Nahrain University 16.4 (2013): 161-166.

Fortunato, Jucélia J., et al. "Effects of β-carboline harmine on behavioral and physiological parameters observed in the chronic mild stress model: Further evidence of antidepressant properties." Brain research bulletin 81.4-5 (2010): 491-496.

Boeira, Jane M., et al. "Genotoxic effects of the alkaloids harman and harmine assessed by comet assay and chromosome aberration test in mammalian cells in vitro." Basic & Clinical Pharmacology & Toxicology 89.6 (2001): 287-294.

Hamsa, T. P., and Girija Kuttan. "Harmine inhibits tumour specific neo-vessel formation by regulating VEGF, MMP, TIMP and pro-inflammatory mediators both in vivo and in vitro." European journal of pharmacology 649.1-3 (2010): 64-73.

Sun, Piyun, et al. "Harmine mediated neuroprotection via evaluation of glutamate transporter 1 in a rat model of global cerebral ischemia." Neuroscience letters 583 (2014): 32-36.

Herraiz, Tomás, and Juan Galisteo. "Hydroxyl radical reactions and the radical scavenging activity of β-carboline alkaloids." Food chemistry 172 (2015): 640-649.

Kim, Hoon, Sergey O. Sablin, and Rona R. Ramsay. "Inhibition of monoamine oxidase A by β-carboline derivatives." Archives of biochemistry and biophysics 337.1 (1997): 137-142.

Nafisi, Shohreh, Zahra Mokhtari Malekabady, and Mohammad Ali Khalilzadeh. "Interaction of β-carboline alkaloids with RNA." DNA and cell biology 29.12 (2010): 753-761.

Stanković, Dalibor, et al. "New electrochemical method for the determination of β-carboline alkaloids, harmalol and harmine, in human urine samples and in Banisteriopsis caapi." Microchemical Journal 118 (2015): 95-100.

Zetler, G., G. Back, and H. Iven. "Pharmacokinetics in the rat of the hallucinogenic alkaloids harmine and harmaline." Naunyn-Schmiedeberg's archives of pharmacology 285.3 (1974): 273-292.

Ayoob, Iram, et al. "Phytochemical and cytotoxic evaluation of peganum harmala: structure activity relationship studies of harmine." ChemistrySelect 2.10 (2017): 2965-2968.

Porbarkhordari, Elham, et al. "The hypoglycemic effects of an ethanol extract of peganum harmala in streptozotocin-induced diabetic rats." Iranian Journal of Pharmaceutical Sciences 10.3 (2014): 47-54.

Waki, Hironori, et al. "The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARγ expression." Cell metabolism 5.5 (2007): 357-370.

Zhao, Lei, and Michael Wink. "The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype." PeerJ 1 (2013): e174.

Zhong, Zeqi, Yuan Tao, and Hui Yang. "Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury." Molecular medicine reports 12.6 (2015): 7985-7991.

Nafisi, Shohreh, et al. "β-Carboline alkaloids bind DNA." Journal of Photochemistry and Photobiology B: Biology 100.2 (2010): 84-91.

 

[dreamer042]

Pic-Taylor, Aline, et al. "Behavioural and neurotoxic effects of ayahuasca infusion (Banisteriopsis caapi and Psychotria viridis) in female Wistar rat." Behavioural processes 118 (2015): 102-110.

 

[Bancopuma]

Bouso, J.C., Pedrero-Pérez, E.J., Gandy, S. & Alcázar-Córcoles, M.A. 2016. Measuring the subjective: revisiting the psychometric properties of three rating scales that assess the acute effects of hallucinogens. Human Psychopharmacology, 31, 356-372.

Franquesa, A., Sainz-Cort, A., Gandy, S. Soler, J., Alcázar-Córcoles, M.A. & Bouso, J.C. 2018. Psychological variables implied in the therapeutic effect of ayahuasca: A contextual approach. Psychiatry Research, 264, 334-339.

Davis, A.K., Barsuglia, J.P., Lancelotta, R., Grant, R.M. & Renn, E. 2018. The epidemiology of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) use: Benefits, consequences, patterns of use, subjective effects, and reasons for consumption. Journal of Psychopharmacology, In Press, 1–14.

 

[EntreNous]

Just another day on the Nexus.

I've been very interested in finding literature on harmala alkaloids for the last year. The search engines I'm using just aren't up to the task and often when I find something interesting all I get to see is an abstract. Fortunately tonight an obscure DuckDuckGo listing led me to a dmt nexus thread that in turn led me to this decade old thread. I've been clicking and scrolling for hours now, absolutely floored by the sheer volume in information in this particular thread. My curiosity and patience paid off as I neared the bottom of the last page of this thread.

All I can say is thanks to everyone who contributed here and especially to dreamer042 for the massive harmala data dump. Harmala has been a great ally for me and I need to be able to speak coherently on the subject. Simply saying "it's good for me" isn't likely to convince anyone who is dealing with my particular set of issues to look at beta carbolines.

I now have more information than I can process and much of it will lead to more research so I can better understand the data as presented. As a layman I recognize the pitfalls of "just enough knowledge to be dangerous" so at some point I may ask one of our more astute members (astuter than me, anyway) for clarification.

It seems like every time I visit the nexus my ignorance level falls in direct proportion to my rising level of gratitude. In that sense this was just another day on the nexus. Thanks friends.

 

[blue.magic]

I am looking for

The Alkaloids: Chemistry and Physiology, Vol. 2"

It contains Manske's method for P. harmala extraction for which I need more details.

I can find it on Science Direct, but it's of course paid and I need to be registered.

The book is not avaiable on sci-hub nor torrents... I am lost. Can you help me get that material if you have possibly free access to it?

 

[dreamer042]

That one is posted here:

Access to full text or reprints - Collaborative Research Project - Welcome to the DMT-Nexus

Please use that thread for requests instead of this one, thanks.

 

[SnozzleBerry]

N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function

Steven A. Barker*

 

[Loveall]

Snozzle uploaded this in chat and asked that we put it here.

Sub-acute and long-term effects of ayahuasca on affect and cognitive
thinking style and their association with ego dissolution

 

[SnozzleBerry]

DMT Models the Near-Death Experience

Citation: Timmermann C, Roseman L, Williams L, Erritzoe D, Martial C, Cassol H, Laureys S, Nutt D and Carhart-Harris R (2018) DMT Models the Near-Death Experience. Front. Psychol. 9:1424. doi: 10.3389/fpsyg.2018.01424

 

[pastanostra]

Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial

Cancer patients often develop chronic, clinically significant symptoms of depression and anxiety. Previous studies suggest that psilocybin may decrease depression and anxiety in cancer patients. The effects of psilocybin were studied in 51 cancer patients ...

www.ncbi.nlm.nih.gov

 

[Loveall]

Dark Classics in Chemical Neuroscience: N,N‑Dimethyltryptamine
(DMT)
Lindsay P. Cameron† and David E. Olson

https://pubs.acs.org/doi/abs/10.1021/acschemneuro.8b00101

A review paper.

 

[Simply_Me]

I posted this elsewhere before I found this post. Please forgive the duplication

QEEG STUDIES OF THE ACUTE EFFECTS OF THE VISIONARY TRYPTAMINE DMT

 

[sauSage]

Scientists Gave MDMA to Octopuses—and What Happened Was Profound

When humans take the drug MDMA, versions of which are known as molly or ecstasy, they commonly feel very happy, extraverted, and particularly interested in physical touch. A group of scientists recently wondered whether this drug might have a similar effect on other species—specifically...

gizmodo.com

That's a darn lucky octopus...

 

[dreamer042]

An interesting study, but highly flawed.

The experiment needs to be repeated with a funktion one blasting Tipper and a few hundred glowsticks in the tank. 8)

full article is attached:
Edsinger, Eric and Dölen, Gül (2018 ) A conserved role for serotonergic neurotransmission in mediating social behavior in octopus. Current Biology, DOI: 10.1016/j.cub.2018.07.061