Sciencedaily.com article:
Human minibrains reveal effects of psychedelic substance
Study brings first evidence that psychedelics interfere with molecular signaling related to learning and memory in the human brain tissue. Minibrains, also known as cerebral organoids, have been considered a breakthrough in neuroscience studies.
Human minibrains reveal effects of psychedelic substance
Scientific article:
Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT
Vanja Dakic, Juliana Minardi Nascimento, Rafaela Costa Sartore, Renata de Moraes Maciel, Draulio B. de Araujo, Sidarta Ribeiro, Daniel Martins-de-Souza & Stevens K. Rehen
Scientific Reports 7, Article number: 12863 (2017)
doi: 10.1038/s41598-017-12779-5
abstract:
Dimethyltryptamines are entheogenic serotonin-like molecules present in traditional Amerindian medicine recently associated with cognitive gains, antidepressant effects, and changes in brain areas related to attention. Legal restrictions and the lack of adequate experimental models have limited the understanding of how such substances impact human brain metabolism. Here we used shotgun mass spectrometry to explore proteomic differences induced by 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) on human cerebral organoids. Out of the 6,728 identified proteins, 934 were found differentially expressed in 5-MeO-DMT-treated cerebral organoids. In silico analysis reinforced previously reported anti-inflammatory actions of 5-MeO-DMT and revealed modulatory effects on proteins associated with long-term potentiation, the formation of dendritic spines, including those involved in cellular protrusion formation, microtubule dynamics, and cytoskeletal reorganization. Our data offer the first insight about molecular alterations caused by 5-MeO-DMT in human cerebral organoids.
Full text open-access at: Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT - Scientific Reports
Human minibrains reveal effects of psychedelic substance
Study brings first evidence that psychedelics interfere with molecular signaling related to learning and memory in the human brain tissue. Minibrains, also known as cerebral organoids, have been considered a breakthrough in neuroscience studies.
Human minibrains reveal effects of psychedelic substance
Scientific article:
Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT
Vanja Dakic, Juliana Minardi Nascimento, Rafaela Costa Sartore, Renata de Moraes Maciel, Draulio B. de Araujo, Sidarta Ribeiro, Daniel Martins-de-Souza & Stevens K. Rehen
Scientific Reports 7, Article number: 12863 (2017)
doi: 10.1038/s41598-017-12779-5
abstract:
Dimethyltryptamines are entheogenic serotonin-like molecules present in traditional Amerindian medicine recently associated with cognitive gains, antidepressant effects, and changes in brain areas related to attention. Legal restrictions and the lack of adequate experimental models have limited the understanding of how such substances impact human brain metabolism. Here we used shotgun mass spectrometry to explore proteomic differences induced by 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) on human cerebral organoids. Out of the 6,728 identified proteins, 934 were found differentially expressed in 5-MeO-DMT-treated cerebral organoids. In silico analysis reinforced previously reported anti-inflammatory actions of 5-MeO-DMT and revealed modulatory effects on proteins associated with long-term potentiation, the formation of dendritic spines, including those involved in cellular protrusion formation, microtubule dynamics, and cytoskeletal reorganization. Our data offer the first insight about molecular alterations caused by 5-MeO-DMT in human cerebral organoids.
Full text open-access at: Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT - Scientific Reports
