Short term changes in the proteome of human cerebral organoids induced by 5-methoxy-N,N-dimethyltryp

[cave paintings]

Neat paper I stumbled across. Have not read more than abstract/introduction briefly.

 

[entheogenic-gnosis]

Do you know of a version that's not in PDF form?

-eg

 

[cave paintings]

I found it on a search for some other related papers. Looks very recent, and it is not yet peer-reviewed I believe, and as I said, I haven't read it in depth yet, but figured I'd throw it up here for general interest.
Here is a link to the site I obtained it from, but no.. I don't have it in a non-pdf format, though I could possibly convert it?
Sorry if this is not helpful.
Short term changes in the proteome of human cerebral organoids induced by 5-methoxy-N,N-dimethyltryptamine

 

[downwardsfromzero]

Very interesting paper. As it appears to me, the findings give the perceived benefits of 5-MeO administration something of a real scientific basis.

This - among a number of things - seems significant:

we observed major downregulation of mGluR5 after treatment with 5-MeO-DMT, which has a role in the rewarding effects of several drugs of abuse. It was shown that mice lacking the mGluR5 gene do not self-administer cocaine and show no cocaine-induced hyperactivity (Chiamulera et al. 2001)

It would appear that they extrapolate their findings with 5-MeO-DMT across to the perceived benefits of ayahuasca which is not a valid thing to do, and right from the start they appear to conflate DMT and 5-MeO-DMT when really a clear distinction should be made. I suspect a decent peer review should clear that up.

 

[Psybin]

It would appear that they extrapolate their findings with 5-MeO-DMT across to the perceived benefits of ayahuasca which is not a valid thing to do, and right from the start they appear to conflate DMT and 5-MeO-DMT when really a clear distinction should be made. I suspect a decent peer review should clear that up.

I think the authors may actually be referring to dimethyltryptamines as a family of compounds, and stating that they are present in ayahuasca, virola snuff, and other entheogens used by Amerindian tribes. Was this the passage you were referring to?

Dimethyltryptamines are hallucinogenic serotonin-like molecules present in
traditional Amerindian medicine (e.g. Ayahuasca, Virola) recently associated
with cognitive gains, antidepressant effects and changes in brain areas
related to attention, self-referential thought, and internal mentation.

My guess is that the line below is a typo and should read dimethyltriptamines:

Here we used shotgun mass spectrometry to
explore proteomic differences induced by dimethyltryptamine (5-methoxy-N,N
dimethyltryptamine, 5-MeO-DMT) on human cerebral organoids.

I could be wrong, but I noticed other basic syntactical errors that could easily be a result of translation from Portuguese to English.