polytrip said:It is just as likely to decrease the amount of neural connections. DMT is indeed a receptor agonist, but it's effect is clearly a diminished serotonergic activity as brainscans reveal.Melodic Catastrophe said:On the other hand... If the fetus' brain can handle it, it seems like it would only help it in the long run by building more neural connections.
Taking a substance that DOWNregulates the amount of serotonin receptors in a brain that has yet to build all of it's neural connections, in a period of rapid devellopment where normally every second neural connections are being build that are vital for it's later functioning, could likely lead to LESS neural connections.
You also have to see that indian tribal society's are not like ours. Our society may be a lot more stressfull.
If you've got less serotonin receptors you're more susceptible to depressions and compulsive disorders like anorexia, but in society's where ayahuasca is a part of life, there may be less social stress that could accumulate to having those disorders, so having less serotonin receptors could maybe stay unnoticed in those society's. And those people take ayahuasca as well throughout their life, compensating with it's antidepressant effect maybe, the lesser amount of receptors they may have.
People always say that DMT is a 5ht-receptor agonist, assuming that that means more neural activity. But in the case of DMT it clearly means LESS neural activity in the neo-cortex. You can clearly see that on brainscans.
I dont think there is any evidence at all of seratonin down regulation with the use of ayahuasca. Ayahuasca is not DMT. I dont see the relevance to the natives using ayahuasca in relation to these brainscan studies of people on DMT. Caapi is shown to upregulate seratonin receptors..
