I have found that since starting Zoloft 100mg, DMT has almost no effect on me. A substantial smoked dose gives me a weak body rush lasting about 30 seconds. That's it. Before Zoloft, DMT affected me normally. A friend who takes Paxil has experienced the same thing. Anyone else experience this, first-, second-, or third-hand?
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SSRI blocking effects of DMT?
- Thread starter potato
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Underclocked
Rising Star
Pharmaceuticals kill it.... Almost all and any will rapidly decrease the effects. Example is a friend of mine takes adderall and always takes a 2-3 day break before indulging in the molecule. Sometimes 5 days if there is going to be any MAOi involved. That may be reckless but has noticed no effects and has been doing it for about a year meow.
RoundAbout
Rising Star
Underclocked said:
That's not true. SSRIs are known to reduce/change the effects of vaporized DMT, and I'm sure many other drugs change the experience also... but certainly not all. I don't think I need to offer personal anecdotes or paste in others' experiences to support this.
Fruit is life
Rising Star
Yeah pretty sure serotonin will compete with dmt for receptor sites, my friend who is on a pharmacuetical ssri is quite insensitive to dmt, although it obviously still effects him, there is not much substance to his experiences he reports, and he needs 5x the dose I would need to get somewhere
Allegro Vivo
Rising Star
I've read that SSRIs are experience-dampeners for sure. From recent personal experience I can attest that, for me, the SARI trazodone (Desyrel) certainly seems to inhibit DMT. This is all new personal territory but I believe some (?) of the mechanism of action is the same. Hey, three of the the initials are identical! (it's a serotonin antagonist and reuptake inhibitor)
